Gene description for SEL1L
Gene name sel-1 suppressor of lin-12-like (C. elegans)
Gene symbol SEL1L
Other names/aliases PRO1063
SEL1-LIKE
SEL1L1
Species Homo sapiens
 Database cross references - SEL1L
ExoCarta ExoCarta_6400
Entrez Gene 6400
HGNC 10717
MIM 602329
UniProt Q9UBV2  
 SEL1L identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for SEL1L
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    Notch signaling pathway GO:0007219 IEA
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 TAS
    retrograde protein transport, ER to cytosol GO:0030970 IMP
    response to endoplasmic reticulum stress GO:0034976 IEA
    protein stabilization GO:0050821 TAS
Subcellular Localization
    Hrd1p ubiquitin ligase complex GO:0000836 TAS
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified SEL1L in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for SEL1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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