Gene description for B4GALT3
Gene name UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Gene symbol B4GALT3
Other names/aliases beta4Gal-T3
Species Homo sapiens
 Database cross references - B4GALT3
ExoCarta ExoCarta_8703
Entrez Gene 8703
HGNC 926
MIM 604014
UniProt O60512  
 B4GALT3 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for B4GALT3
Molecular Function
    galactosyltransferase activity GO:0008378 TAS
    metal ion binding GO:0046872 IEA
    N-acetyllactosamine synthase activity GO:0003945 IEA
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity GO:0003831 IEA
Biological Process
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    carbohydrate metabolic process GO:0005975 TAS
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
    small molecule metabolic process GO:0044281 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    keratan sulfate metabolic process GO:0042339 TAS
    keratan sulfate biosynthetic process GO:0018146 TAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    cytoplasm GO:0005737 IDA
    integral component of membrane GO:0016021 IEA
    Golgi cisterna membrane GO:0032580 IEA
    extracellular exosome GO:0070062 IDA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified B4GALT3 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for B4GALT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SAT  
Two-hybrid Homo sapiens
2 ARL15 54622
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which B4GALT3 is involved
PathwayEvidenceSource
Keratan sulfate biosynthesis TAS Reactome
N-Glycan antennae elongation TAS Reactome





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