Gene description for KDSR
Gene name 3-ketodihydrosphingosine reductase
Gene symbol KDSR
Other names/aliases DHSR
FVT1
SDR35C1
Species Homo sapiens
 Database cross references - KDSR
ExoCarta ExoCarta_2531
Vesiclepedia VP_2531
Entrez Gene 2531
HGNC 4021
MIM 136440
UniProt Q06136  
 KDSR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for KDSR
Molecular Function
    protein binding GO:0005515 IPI
    3-dehydrosphinganine reductase activity GO:0047560 IBA
    3-dehydrosphinganine reductase activity GO:0047560 IDA
    3-dehydrosphinganine reductase activity GO:0047560 IMP
    3-dehydrosphinganine reductase activity GO:0047560 TAS
    NADPH binding GO:0070402 ISS
Biological Process
    3-keto-sphinganine metabolic process GO:0006666 IBA
    3-keto-sphinganine metabolic process GO:0006666 IDA
    3-keto-sphinganine metabolic process GO:0006666 IMP
    sphingolipid biosynthetic process GO:0030148 IBA
    sphingolipid biosynthetic process GO:0030148 IMP
    sphingolipid biosynthetic process GO:0030148 ISS
    sphingolipid biosynthetic process GO:0030148 TAS
Subcellular Localization
    extracellular space GO:0005615 TAS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified KDSR in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KDSR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACOT7 11332
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 C5AR1  
Affinity Capture-MS Homo sapiens
4 VTI1B 10490
Affinity Capture-MS Homo sapiens
5 RAB1A 5861
Co-fractionation Homo sapiens
6 TSPAN15 23555
Affinity Capture-MS Homo sapiens
7 TTYH3 80727
Affinity Capture-MS Homo sapiens
8 HCST  
Affinity Capture-MS Homo sapiens
9 CD53 963
Affinity Capture-MS Homo sapiens
10 NDUFB5 4711
Affinity Capture-MS Homo sapiens
11 MFSD8 256471
Affinity Capture-MS Homo sapiens
12 TNFSF18 8995
Affinity Capture-MS Homo sapiens
13 IGSF8 93185
Affinity Capture-MS Homo sapiens
14 COPB2 9276
Affinity Capture-MS Homo sapiens
15 MGAT1 4245
Affinity Capture-MS Homo sapiens
16 ATP5C1 509
Affinity Capture-MS Homo sapiens
17 ACP2 53
Affinity Capture-MS Homo sapiens
18 STXBP3 6814
Affinity Capture-MS Homo sapiens
19 NDUFAF1  
Affinity Capture-MS Homo sapiens
20 PGAM1 5223
Affinity Capture-MS Homo sapiens
21 CLGN 1047
Co-fractionation Homo sapiens
22 STX12 23673
Affinity Capture-MS Homo sapiens
23 RAB1B 81876
Co-fractionation Homo sapiens
24 TSPAN2 10100
Affinity Capture-MS Homo sapiens
25 TMEM120A 83862
Affinity Capture-MS Homo sapiens
26 EXTL3 2137
Affinity Capture-MS Homo sapiens
27 POMGNT1 55624
Affinity Capture-MS Homo sapiens
28 FUT8 2530
Affinity Capture-MS Homo sapiens
29 TSPAN3 10099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GPR35  
Affinity Capture-MS Homo sapiens
31 CERS2 29956
Affinity Capture-MS Homo sapiens
32 PILRB 29990
Affinity Capture-MS Homo sapiens
33 SARM1 23098
Affinity Capture-MS Homo sapiens
34 YIF1A 10897
Affinity Capture-MS Homo sapiens
35 VCP 7415
Co-fractionation Homo sapiens
36 RELL1 768211
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 RDH13  
Co-fractionation Homo sapiens
38 IPPK  
Affinity Capture-MS Homo sapiens
39 RPN1 6184
Co-fractionation Homo sapiens
40 VMA21  
Affinity Capture-MS Homo sapiens
41 TMEM56  
Affinity Capture-MS Homo sapiens
42 CD63 967
Affinity Capture-MS Homo sapiens
43 XYLT2 64132
Affinity Capture-MS Homo sapiens
44 COA1  
Affinity Capture-MS Homo sapiens
45 ATP5B 506
Affinity Capture-MS Homo sapiens
46 SSR4 6748
Co-fractionation Homo sapiens
47 REEP5 7905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 VIPR2  
Affinity Capture-MS Homo sapiens
49 RPN2 6185
Co-fractionation Homo sapiens
50 CANX 821
Co-fractionation Homo sapiens
51 CYTB  
Affinity Capture-MS Homo sapiens
52 SLC35F2 54733
Affinity Capture-MS Homo sapiens
53 ATP5F1 515
Affinity Capture-MS Homo sapiens
54 EPRS 2058
Co-fractionation Homo sapiens
55 LPAR1 1902
Affinity Capture-MS Homo sapiens
56 CD27  
Affinity Capture-MS Homo sapiens
57 MAPK6  
Two-hybrid Homo sapiens
58 RABAC1 10567
Affinity Capture-MS Homo sapiens
59 RPA3 6119
Proximity Label-MS Homo sapiens
60 ACAD9 28976
Affinity Capture-MS Homo sapiens
61 FNDC3A 22862
Affinity Capture-MS Homo sapiens
62 CERS6  
Affinity Capture-MS Homo sapiens
63 TSPAN17 26262
Affinity Capture-MS Homo sapiens
64 SGCZ  
Affinity Capture-MS Homo sapiens
65 NDUFC2 4718
Affinity Capture-MS Homo sapiens
66 ARAF 369
Affinity Capture-MS Homo sapiens
67 REEP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 B4GALT3 8703
Affinity Capture-MS Homo sapiens
69 YIF1B 90522
Affinity Capture-MS Homo sapiens
70 IMMT 10989
Affinity Capture-MS Homo sapiens
71 IFNGR2  
Affinity Capture-MS Homo sapiens
72 SLC19A2 10560
Affinity Capture-MS Homo sapiens
73 TSPAN5 10098
Affinity Capture-MS Homo sapiens
74 Ercc6l  
Affinity Capture-MS Mus musculus
75 ATP5J 522
Affinity Capture-MS Homo sapiens
76 RTN3 10313
Affinity Capture-MS Homo sapiens
77 ACADSB 36
Co-fractionation Homo sapiens
78 FKRP 79147
Affinity Capture-MS Homo sapiens
79 ABCC4 10257
Affinity Capture-MS Homo sapiens
80 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
81 EBP  
Affinity Capture-MS Homo sapiens
82 ATP6V0C 527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 GOLGA5 9950
Affinity Capture-MS Homo sapiens
84 TSPAN6 7105
Affinity Capture-MS Homo sapiens
85 POMK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 LPAR2 9170
Affinity Capture-MS Homo sapiens
87 HSDL1 83693
Affinity Capture-MS Homo sapiens
88 KRAS 3845
Synthetic Lethality Homo sapiens
89 HTR1B  
Affinity Capture-MS Homo sapiens
90 CNR2  
Affinity Capture-MS Homo sapiens
91 NDUFB3 4709
Affinity Capture-MS Homo sapiens
92 ECSIT 51295
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KDSR is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Sphingolipid de novo biosynthesis TAS Reactome
Sphingolipid metabolism TAS Reactome





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