Gene description for NDUFC2
Gene name NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
Gene symbol NDUFC2
Other names/aliases B14.5b
CI-B14.5b
HLC-1
NADHDH2
Species Homo sapiens
 Database cross references - NDUFC2
ExoCarta ExoCarta_4718
Vesiclepedia VP_4718
Entrez Gene 4718
HGNC 7706
MIM 603845
UniProt O95298  
 NDUFC2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NDUFC2
Molecular Function
    protein binding GO:0005515 IPI
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
Biological Process
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
    aerobic respiration GO:0009060 NAS
    positive regulation of mitochondrial membrane potential GO:0010918 IEA
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    proton motive force-driven mitochondrial ATP synthesis GO:0042776 NAS
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 IEA
    proton transmembrane transport GO:1902600 IEA
    negative regulation of reactive oxygen species biosynthetic process GO:1903427 IEA
    positive regulation of ATP biosynthetic process GO:2001171 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    plasma membrane GO:0005886 TAS
    azurophil granule membrane GO:0035577 TAS
    respiratory chain complex I GO:0045271 IBA
    respiratory chain complex I GO:0045271 IDA
    respiratory chain complex I GO:0045271 NAS
 Experiment description of studies that identified NDUFC2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDUFC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFAF1  
Affinity Capture-MS Homo sapiens
2 NDUFV1 4723
Affinity Capture-MS Homo sapiens
3 MAGEA8  
Affinity Capture-MS Homo sapiens
4 CRELD1 78987
Affinity Capture-MS Homo sapiens
5 CISD3 284106
Affinity Capture-MS Homo sapiens
6 NDUFA12 55967
Affinity Capture-MS Homo sapiens
7 CHCHD4  
Affinity Capture-MS Homo sapiens
8 GJA8  
Affinity Capture-MS Homo sapiens
9 NDUFB8 4714
Affinity Capture-MS Homo sapiens
10 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
11 FKBP9 11328
Co-fractionation Homo sapiens
12 COA1  
Affinity Capture-MS Homo sapiens
13 TACR1  
Affinity Capture-MS Homo sapiens
14 SLC18A1  
Affinity Capture-MS Homo sapiens
15 NDUFV3 4731
Affinity Capture-MS Homo sapiens
16 NDUFS5 4725
Affinity Capture-MS Homo sapiens
17 NDUFA1 4694
Affinity Capture-MS Homo sapiens
18 NDUFB10 4716
Affinity Capture-MS Homo sapiens
19 SIDT2 51092
Affinity Capture-MS Homo sapiens
20 NDUFA13 51079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ANKRD40 91369
Affinity Capture-MS Homo sapiens
22 C3AR1  
Affinity Capture-MS Homo sapiens
23 IMPDH1 3614
Affinity Capture-MS Homo sapiens
24 NDUFB1 4707
Affinity Capture-MS Homo sapiens
25 ND5 4540
Affinity Capture-MS Homo sapiens
26 LPAR6  
Affinity Capture-MS Homo sapiens
27 RPA2 6118
Proximity Label-MS Homo sapiens
28 NDUFB7 4713
Affinity Capture-MS Homo sapiens
29 NDUFA9 4704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MTCH2 23788
Co-fractionation Homo sapiens
31 NDUFB5 4711
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
32 NDUFS4 4724
Affinity Capture-MS Homo sapiens
33 TSPAN15 23555
Affinity Capture-MS Homo sapiens
34 GCGR  
Affinity Capture-MS Homo sapiens
35 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
37 WBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SLC18A2  
Affinity Capture-MS Homo sapiens
39 SNX25 83891
Affinity Capture-MS Homo sapiens
40 COX6B1 1340
Affinity Capture-MS Homo sapiens
41 NACC1 112939
Affinity Capture-MS Homo sapiens
42 FFAR1  
Affinity Capture-MS Homo sapiens
43 NDUFA8 4702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 METAP1D  
Affinity Capture-MS Homo sapiens
45 KDSR 2531
Affinity Capture-MS Homo sapiens
46 NDUFB9 4715
Affinity Capture-MS Homo sapiens
47 TMEM126B 55863
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 IL2RA  
Affinity Capture-MS Homo sapiens
49 NDUFA2 4695
Affinity Capture-MS Homo sapiens
50 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ND2 4536
Affinity Capture-MS Homo sapiens
52 GPR34  
Affinity Capture-MS Homo sapiens
53 NDUFA7 4701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 TIMMDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 NDUFB6 4712
Affinity Capture-MS Homo sapiens
56 NDUFA6  
Affinity Capture-MS Homo sapiens
57 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
59 NDUFB11 54539
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 YIPF3 25844
Affinity Capture-MS Homo sapiens
61 NDUFB3 4709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 DNAJC30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 NDUFV2 4729
Affinity Capture-MS Homo sapiens
64 OGDH 4967
Co-fractionation Homo sapiens
65 ND4 4538
Affinity Capture-MS Homo sapiens
66 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 NDUFA3  
Affinity Capture-MS Homo sapiens
68 SCCPDH 51097
Co-fractionation Homo sapiens
69 FUT1  
Affinity Capture-MS Homo sapiens
70 ECSIT 51295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 NDUFA10 4705
Affinity Capture-MS Homo sapiens
72 TMEM185A  
Affinity Capture-MS Homo sapiens
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