Gene description for SNX25
Gene name sorting nexin 25
Gene symbol SNX25
Other names/aliases MSTP043
SBBI31
Species Homo sapiens
 Database cross references - SNX25
ExoCarta ExoCarta_83891
Entrez Gene 83891
HGNC 21883
UniProt Q9H3E2  
 SNX25 identified in exosomes derived from the following tissue/cell type
Malignant pleural effusions 14975938    
Neuroblastoma cells 25944692    
 Gene ontology annotations for SNX25
Molecular Function
    phosphatidylinositol binding GO:0035091 IEA
    type I transforming growth factor beta receptor binding GO:0034713 IEA
    molecular_function GO:0003674 ND
Biological Process
    protein transport GO:0015031 IEA
    negative regulation of pathway-restricted SMAD protein phosphorylation GO:0060394 IMP
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP
    receptor catabolic process GO:0032801 IMP
Subcellular Localization
    cellular_component GO:0005575 ND
    endosome membrane GO:0010008 IEA
 Experiment description of studies that identified SNX25 in exosomes
1
Experiment ID 51
ISEV standards
EM
EV Biophysical techniques
HSP90
EV Cytosolic markers
MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Breast cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
2
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SNX25
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SNX25 is involved
No pathways found





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