Gene description for NDUFA1
Gene name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
Gene symbol NDUFA1
Other names/aliases CI-MWFE
MWFE
ZNF183
Species Homo sapiens
 Database cross references - NDUFA1
ExoCarta ExoCarta_4694
Entrez Gene 4694
HGNC 7683
MIM 300078
UniProt O15239  
 NDUFA1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NDUFA1
Molecular Function
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
Biological Process
    cellular metabolic process GO:0044237 TAS
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
    small molecule metabolic process GO:0044281 TAS
    respiratory electron transport chain GO:0022904 TAS
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial membrane GO:0031966 IDA
    integral component of membrane GO:0016021 IEA
    mitochondrial respiratory chain complex I GO:0005747 NAS
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified NDUFA1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NDUFA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NDUFA1 is involved
PathwayEvidenceSource
Respiratory electron transport TAS Reactome





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