Gene description for NDUFS4
Gene name NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Gene symbol NDUFS4
Other names/aliases AQDQ
CI-18
Species Homo sapiens
 Database cross references - NDUFS4
ExoCarta ExoCarta_4724
Vesiclepedia VP_4724
Entrez Gene 4724
HGNC 7711
MIM 602694
UniProt O43181  
 NDUFS4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NDUFS4
Molecular Function
    protein binding GO:0005515 IPI
    NADH dehydrogenase (ubiquinone) activity GO:0008137 IMP
    NADH dehydrogenase (ubiquinone) activity GO:0008137 IMP
Biological Process
    regulation of protein phosphorylation GO:0001932 IMP
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
    brain development GO:0007420 IMP
    aerobic respiration GO:0009060 NAS
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    proton motive force-driven mitochondrial ATP synthesis GO:0042776 NAS
    response to cAMP GO:0051591 IMP
    reactive oxygen species metabolic process GO:0072593 IMP
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    respiratory chain complex I GO:0045271 IBA
    respiratory chain complex I GO:0045271 IDA
    respiratory chain complex I GO:0045271 IMP
 Experiment description of studies that identified NDUFS4 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDUFS4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLIRP 81892
Proximity Label-MS Homo sapiens
2 NDUFB8 4714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CACNA2D1 781
Co-fractionation Homo sapiens
4 VAPA 9218
Affinity Capture-MS Homo sapiens
5 NUP188 23511
Co-fractionation Homo sapiens
6 TSHZ2  
Affinity Capture-MS Homo sapiens
7 TRUB2  
Proximity Label-MS Homo sapiens
8 NDUFB5 4711
Co-fractionation Homo sapiens
9 NGRN  
Proximity Label-MS Homo sapiens
10 UQCRB 7381
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
11 RPL14 9045
Co-fractionation Homo sapiens
12 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
13 PRRT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FUBP3 8939
Co-fractionation Homo sapiens
15 NDUFA4 4697
Affinity Capture-MS Homo sapiens
16 MARC1  
Co-fractionation Homo sapiens
17 MTRF1  
Proximity Label-MS Homo sapiens
18 GFM2 84340
Proximity Label-MS Homo sapiens
19 CCDC90B  
Proximity Label-MS Homo sapiens
20 UBE2G2  
Two-hybrid Homo sapiens
21 LRPPRC 10128
Proximity Label-MS Homo sapiens
22 TBL2 26608
Co-fractionation Homo sapiens
23 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CRYZ 1429
Proximity Label-MS Homo sapiens
25 TFAM 7019
Proximity Label-MS Homo sapiens
26 PMPCA 23203
Proximity Label-MS Homo sapiens
27 SDHB 6390
Co-fractionation Homo sapiens
28 GPR34  
Affinity Capture-MS Homo sapiens
29 NDUFA7 4701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 HINT2 84681
Proximity Label-MS Homo sapiens
31 ABCD3 5825
Co-fractionation Homo sapiens
32 C21orf33  
Proximity Label-MS Homo sapiens
33 MRPS26 64949
Proximity Label-MS Homo sapiens
34 SURF1  
Proximity Label-MS Homo sapiens
35 ATP5O 539
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
36 EXD2  
Proximity Label-MS Homo sapiens
37 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 NDUFV1 4723
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
39 ATP6V0D1 9114
Co-fractionation Homo sapiens
40 PMPCB 9512
Proximity Label-MS Homo sapiens
41 NDUFA11 126328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 FASTKD2  
Proximity Label-MS Homo sapiens
43 NDUFS1 4719
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
44 COX7A2L 9167
Affinity Capture-MS Homo sapiens
45 NDUFS5 4725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MTERF3  
Proximity Label-MS Homo sapiens
47 NDUFB10 4716
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
48 MDH2 4191
Proximity Label-MS Homo sapiens
49 PAM16  
Co-fractionation Homo sapiens
50 CYP2J2  
Affinity Capture-MS Homo sapiens
51 EXTL3 2137
Affinity Capture-MS Homo sapiens
52 DLAT 1737
Co-fractionation Homo sapiens
53 ATP5A1 498
Co-fractionation Homo sapiens
54 C6orf203  
Proximity Label-MS Homo sapiens
55 COX15 1355
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
56 FASTKD5  
Proximity Label-MS Homo sapiens
57 PRPH 5630
Co-fractionation Homo sapiens
58 NDUFB7 4713
Affinity Capture-MS Homo sapiens
59 TSFM 10102
Proximity Label-MS Homo sapiens
60 PARK2  
Affinity Capture-MS Homo sapiens
61 ND5 4540
Affinity Capture-MS Homo sapiens
62 EMP3 2014
Affinity Capture-MS Homo sapiens
63 CHCHD3 54927
Co-fractionation Homo sapiens
64 NDUFA8 4702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
65 IL1R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 TUFM 7284
Proximity Label-MS Homo sapiens
67 HSCB 150274
Proximity Label-MS Homo sapiens
68 CYB5A 1528
Co-fractionation Homo sapiens
69 GALNT6 11226
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 GDPD5 81544
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CCDC109B 55013
Proximity Label-MS Homo sapiens
72 NDUFA2 4695
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
73 CYC1 1537
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
74 MCU 90550
Proximity Label-MS Homo sapiens
75 MRPL11 65003
Proximity Label-MS Homo sapiens
76 MTRF1L  
Proximity Label-MS Homo sapiens
77 UQCRH 7388
Co-fractionation Homo sapiens
78 FUBP1 8880
Co-fractionation Homo sapiens
79 NDUFV3 4731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 TMEM70  
Proximity Label-MS Homo sapiens
81 NDUFAF3 25915
Co-fractionation Homo sapiens
82 SLC25A5 292
Co-fractionation Homo sapiens
83 COX4I1 1327
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
84 MTG2  
Proximity Label-MS Homo sapiens
85 ND1  
Affinity Capture-MS Homo sapiens
86 GJA8  
Affinity Capture-MS Homo sapiens
87 OTC 5009
Proximity Label-MS Homo sapiens
88 MRRF  
Proximity Label-MS Homo sapiens
89 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
90 MRPS12  
Proximity Label-MS Homo sapiens
91 MTIF2 4528
Proximity Label-MS Homo sapiens
92 RPS2 6187
Co-fractionation Homo sapiens
93 NDUFA13 51079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 NDUFA9 4704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 SLC25A51  
Proximity Label-MS Homo sapiens
96 CLPP 8192
Proximity Label-MS Homo sapiens
97 MTIF3  
Proximity Label-MS Homo sapiens
98 UQCRC2 7385
Co-fractionation Homo sapiens
99 CTNNB1 1499
Affinity Capture-MS Homo sapiens
100 GOLT1B 51026
Affinity Capture-MS Homo sapiens
101 CRELD1 78987
Affinity Capture-MS Homo sapiens
102 ATP5F1 515
Co-fractionation Homo sapiens
103 COX6B1 1340
Affinity Capture-MS Homo sapiens
104 AQP3  
Affinity Capture-MS Homo sapiens
105 TMEM74  
Affinity Capture-MS Homo sapiens
106 C17orf80 55028
Proximity Label-MS Homo sapiens
107 MRPL15 29088
Co-fractionation Homo sapiens
108 SYP  
Affinity Capture-MS Homo sapiens
109 C12orf65  
Proximity Label-MS Homo sapiens
110 KCNE3  
Affinity Capture-MS Homo sapiens
111 TACO1  
Proximity Label-MS Homo sapiens
112 MTG1  
Proximity Label-MS Homo sapiens
113 RPUSD4 84881
Proximity Label-MS Homo sapiens
114 NDUFB3 4709
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
115 COX6C 1345
Co-fractionation Homo sapiens
116 DHX30 22907
Proximity Label-MS Homo sapiens
117 RPS14 6208
Co-fractionation Homo sapiens
118 ACAD9 28976
Proximity Label-MS Homo sapiens
119 VWA8 23078
Proximity Label-MS Homo sapiens
120 VDAC1 7416
Co-fractionation Homo sapiens
121 NDUFV2 4729
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 NDUFC2 4718
Affinity Capture-MS Homo sapiens
123 METTL15  
Proximity Label-MS Homo sapiens
124 FFAR1  
Affinity Capture-MS Homo sapiens
125 C1orf95  
Affinity Capture-MS Homo sapiens
126 ADGRE5 976
Affinity Capture-MS Homo sapiens
127 MCUR1 63933
Proximity Label-MS Homo sapiens
128 NDUFS2 4720
Affinity Capture-MS Homo sapiens
129 TOMM20 9804
Co-fractionation Homo sapiens
130 FUT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 APP 351
Reconstituted Complex Homo sapiens
132 NDUFA1 4694
Affinity Capture-MS Homo sapiens
133 CS 1431
Proximity Label-MS Homo sapiens
134 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
135 ALDOC 230
Co-fractionation Homo sapiens
136 VDAC3 7419
Co-fractionation Homo sapiens
137 AUH 549
Proximity Label-MS Homo sapiens
138 TBRG4 9238
Proximity Label-MS Homo sapiens
139 DNAJC19 131118
Proximity Label-MS Homo sapiens
140 ICT1 3396
Proximity Label-MS Homo sapiens
141 DNAJC30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 LONP1 9361
Proximity Label-MS Homo sapiens
143 M6PR 4074
Co-fractionation Homo sapiens
144 DNAJA3 9093
Proximity Label-MS Homo sapiens
145 NDUFA12 55967
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 ATP2A2 488
Co-fractionation Homo sapiens
147 SSBP1 6742
Proximity Label-MS Homo sapiens
148 ATAD3A 55210
Co-fractionation Homo sapiens
149 VDAC2 7417
Co-fractionation Homo sapiens
150 ARMCX2 9823
Co-fractionation Homo sapiens
151 NDUFS8 4728
Affinity Capture-MS Homo sapiens
152 GFM1 85476
Proximity Label-MS Homo sapiens
153 TEFM  
Proximity Label-MS Homo sapiens
154 MGST3 4259
Co-fractionation Homo sapiens
155 RPL23 9349
Co-fractionation Homo sapiens
156 ATP1A1 476
Co-fractionation Homo sapiens
157 GRSF1 2926
Proximity Label-MS Homo sapiens
158 C1QBP 708
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
159 ATP5C1 509
Co-fractionation Homo sapiens
160 COX7C 1350
Co-fractionation Homo sapiens
161 NDUFB11 54539
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 WFS1 7466
Co-fractionation Homo sapiens
163 METTL17  
Proximity Label-MS Homo sapiens
164 C8orf82  
Proximity Label-MS Homo sapiens
165 OGDH 4967
Co-fractionation Homo sapiens
166 ND4 4538
Affinity Capture-MS Homo sapiens
167 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
168 DDX28  
Proximity Label-MS Homo sapiens
169 ALDOA 226
Co-fractionation Homo sapiens
170 NDUFB4 4710
Affinity Capture-MS Homo sapiens
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