Gene description for ABCD3
Gene name ATP-binding cassette, sub-family D (ALD), member 3
Gene symbol ABCD3
Other names/aliases ABC43
CBAS5
PMP70
PXMP1
ZWS2
Species Homo sapiens
 Database cross references - ABCD3
ExoCarta ExoCarta_5825
Entrez Gene 5825
HGNC 67
MIM 170995
UniProt P28288  
 ABCD3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for ABCD3
Molecular Function
    ATPase activity GO:0016887 IDA
    ATP binding GO:0005524 IDA
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    very long-chain fatty acid catabolic process GO:0042760 IGI
    fatty acid beta-oxidation GO:0006635 IGI
    peroxisome organization GO:0007031 IMP
    fatty acid biosynthetic process GO:0006633 IMP
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 TAS
    mitochondrial inner membrane GO:0005743 IEA
    peroxisome GO:0005777 IDA
    peroxisomal matrix GO:0005782 IDA
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified ABCD3 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ABCD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABCD1  
Two-hybrid Homo sapiens
2 BRF2  
Affinity Capture-MS Homo sapiens
3 ABCD3 5825
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PTP4A3  
Affinity Capture-MS Homo sapiens
5 PGRMC1 10857
Affinity Capture-MS Homo sapiens
6 MLF2 8079
Affinity Capture-MS Homo sapiens
7 PELO 53918
Affinity Capture-MS Homo sapiens
8 MEST 4232
Affinity Capture-MS Homo sapiens
9 C20orf24  
Affinity Capture-MS Homo sapiens
10 PEX19  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
11 COL6A2 1292
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ABCD3 is involved
PathwayEvidenceSource
ABCA transporters in lipid homeostasis TAS Reactome





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