Gene description for ABCD3
Gene name
ATP-binding cassette, sub-family D (ALD), member 3
Gene symbol
ABCD3
Other names/aliases
ABC43 CBAS5 PMP70 PXMP1 ZWS2
Species
Homo sapiens
Database cross references - ABCD3
ExoCarta
ExoCarta_5825
Entrez Gene
5825
HGNC
67
MIM
170995
UniProt
P28288
ABCD3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells
26054723
Hepatocytes
26054723
Gene ontology annotations for ABCD3
Experiment description of studies that identified ABCD3 in exosomes
1
Experiment ID
235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule
mRNA
Identification method
RNA Sequencing
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocellular carcinoma cells
Sample name
HKCI-8
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RT-PCR RNA Sequencing
2
Experiment ID
237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule
mRNA
Identification method
RNA Sequencing
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocytes
Sample name
MIHA
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RNA Sequencing
Protein-protein interactions for ABCD3
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
ABCD1
Two-hybrid
Homo sapiens
2
BRF2
Affinity Capture-MS
Homo sapiens
3
ABCD3
5825
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
4
PTP4A3
Affinity Capture-MS
Homo sapiens
5
PGRMC1
10857
Affinity Capture-MS
Homo sapiens
6
MLF2
8079
Affinity Capture-MS
Homo sapiens
7
PELO
53918
Affinity Capture-MS
Homo sapiens
8
MEST
4232
Affinity Capture-MS
Homo sapiens
9
C20orf24
Affinity Capture-MS
Homo sapiens
10
PEX19
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
Reconstituted Complex
Homo sapiens
Two-hybrid
Homo sapiens
Reconstituted Complex
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
Two-hybrid
Homo sapiens
11
COL6A2
1292
Invivo
Homo sapiens
View the network
image/svg+xml
Pathways in which ABCD3 is involved