Gene description for CLN3
Gene name ceroid-lipofuscinosis, neuronal 3
Gene symbol CLN3
Other names/aliases BTS
JNCL
Species Homo sapiens
 Database cross references - CLN3
ExoCarta ExoCarta_1201
Entrez Gene 1201
HGNC 2074
MIM 607042
UniProt Q13286  
 CLN3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CLN3
Molecular Function
    protein binding GO:0005515 IPI
    unfolded protein binding GO:0051082 TAS
Biological Process
    negative regulation of neuron apoptotic process GO:0043524 ISS
    action potential GO:0001508 ISS
    galactosylceramide metabolic process GO:0006681 IMP
    macroautophagy GO:0016236 NAS
    vesicle transport along microtubule GO:0047496 IMP
    lysosomal lumen pH elevation GO:0035752 IDA
    cytosolic calcium ion homeostasis GO:0051480 ISS
    arginine transport GO:0015809 IDA
    autophagosome fusion GO:0000046 ISS
    vacuolar transport GO:0007034 IBA
    negative regulation of catalytic activity GO:0043086 ISS
    protein catabolic process GO:0030163 NAS
    lysosome organization GO:0007040 ISS
    protein processing GO:0016485 ISS
    ionotropic glutamate receptor signaling pathway GO:0035235 ISS
    sphingomyelin metabolic process GO:0006684 IMP
    membrane organization GO:0061024 ISS
    globoside metabolic process GO:0001575 IMP
    neurotransmitter metabolic process GO:0042133 ISS
    neuromuscular process controlling balance GO:0050885 ISS
    amyloid precursor protein catabolic process GO:0042987 IDA
    lysosomal lumen acidification GO:0007042 IMP
    ceramide metabolic process GO:0006672 IDA
    glucosylceramide metabolic process GO:0006678 IMP
    associative learning GO:0008306 ISS
    negative regulation of proteolysis GO:0045861 ISS
    cellular amino acid metabolic process GO:0006520 ISS
    negative regulation of apoptotic process GO:0043066 IMP
    receptor-mediated endocytosis GO:0006898 IMP
    negative regulation of macroautophagy GO:0016242 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    Golgi stack GO:0005795 IDA
    lysosomal membrane GO:0005765 IDA
    late endosome GO:0005770 ISS
    Golgi membrane GO:0000139 IDA
    trans-Golgi network GO:0005802 IDA
    lysosome GO:0005764 IDA
    synaptic vesicle GO:0008021 IDA
    integral component of endoplasmic reticulum membrane GO:0030176 IDA
    plasma membrane GO:0005886 IDA
    endoplasmic reticulum GO:0005783 IDA
    cytoplasm GO:0005737 IDA
    lysosomal lumen GO:0043202 IMP
    autophagosome GO:0005776 ISS
    caveola GO:0005901 IDA
    early endosome GO:0005769 IDA
    membrane raft GO:0045121 IDA
    Golgi apparatus GO:0005794 IDA
    neuron projection GO:0043005 IDA
    cytosol GO:0005829 ISS
    integral component of membrane GO:0016021 IDA
    mitochondrion GO:0005739 TAS
 Experiment description of studies that identified CLN3 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLN3 is involved
No pathways found





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