Gene description for SEC61A2
Gene name Sec61 alpha 2 subunit (S. cerevisiae)
Gene symbol SEC61A2
Other names/aliases -
Species Homo sapiens
 Database cross references - SEC61A2
ExoCarta ExoCarta_55176
Vesiclepedia VP_55176
Entrez Gene 55176
HGNC 17702
UniProt Q9H9S3  
 SEC61A2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SEC61A2
Molecular Function
    signal sequence binding GO:0005048 IBA
    protein binding GO:0005515 IPI
    protein transmembrane transporter activity GO:0008320 IBA
    ribosome binding GO:0043022 IBA
Biological Process
    SRP-dependent cotranslational protein targeting to membrane, translocation GO:0006616 IBA
    post-translational protein targeting to membrane, translocation GO:0031204 IBA
Subcellular Localization
    Sec61 translocon complex GO:0005784 IBA
 Experiment description of studies that identified SEC61A2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SEC61A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC63 11231
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 CLN3 1201
Affinity Capture-MS Homo sapiens
4 FBXL6  
Affinity Capture-MS Homo sapiens
5 OPALIN  
Affinity Capture-MS Homo sapiens
6 MFSD4  
Affinity Capture-MS Homo sapiens
7 APEX1 328
Affinity Capture-RNA Homo sapiens
8 CUL3 8452
Affinity Capture-MS Homo sapiens
9 BMPR1A 657
Affinity Capture-MS Homo sapiens
10 AQP3  
Affinity Capture-MS Homo sapiens
11 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
12 SYP  
Affinity Capture-MS Homo sapiens
13 PTPN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TSPAN8 7103
Affinity Capture-MS Homo sapiens
15 PTPRE 5791
Affinity Capture-MS Homo sapiens
16 GPR182  
Affinity Capture-MS Homo sapiens
17 USP19 10869
Affinity Capture-MS Homo sapiens
18 ASPH 444
Affinity Capture-MS Homo sapiens
19 PTPRN  
Affinity Capture-MS Homo sapiens
20 VIPR1  
Affinity Capture-MS Homo sapiens
21 ENTPD2 954
Affinity Capture-MS Homo sapiens
22 C9orf72  
Affinity Capture-MS Homo sapiens
23 SLC1A1 6505
Affinity Capture-MS Homo sapiens
24 PTPRO 5800
Affinity Capture-MS Homo sapiens
25 SEC61B 10952
Affinity Capture-MS Homo sapiens
26 EXD2  
Proximity Label-MS Homo sapiens
27 TMEM192 201931
Affinity Capture-MS Homo sapiens
28 CCDC47 57003
Affinity Capture-MS Homo sapiens
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