Gene description for TMEM192
Gene name transmembrane protein 192
Gene symbol TMEM192
Other names/aliases -
Species Homo sapiens
 Database cross references - TMEM192
ExoCarta ExoCarta_201931
Vesiclepedia VP_201931
Entrez Gene 201931
HGNC 26775
UniProt Q8IY95  
 TMEM192 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for TMEM192
Molecular Function
    protein homodimerization activity GO:0042803 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 IDA
    endosome GO:0005768 IDA
    late endosome GO:0005770 IBA
    late endosome GO:0005770 IDA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified TMEM192 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TMEM192
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 RPL14 9045
Affinity Capture-MS Homo sapiens
3 PDCD6 10016
Affinity Capture-MS Homo sapiens
4 ATP6V1B2 526
Affinity Capture-MS Homo sapiens
5 RAMP3  
Affinity Capture-MS Homo sapiens
6 NPC2 10577
Affinity Capture-MS Homo sapiens
7 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
8 TFRC 7037
Affinity Capture-MS Homo sapiens
9 MBLAC2 153364
Affinity Capture-MS Homo sapiens
10 PAEP  
Affinity Capture-MS Homo sapiens
11 LAMP3  
Proximity Label-MS Homo sapiens
12 ERO1L 30001
Affinity Capture-MS Homo sapiens
13 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NAPA 8775
Affinity Capture-MS Homo sapiens
15 TPP1 1200
Affinity Capture-MS Homo sapiens
16 TSPAN6 7105
Affinity Capture-MS Homo sapiens
17 GLB1 2720
Affinity Capture-MS Homo sapiens
18 SYNE4  
Affinity Capture-MS Homo sapiens
19 SPNS1 83985
Affinity Capture-MS Homo sapiens
20 CNP 1267
Affinity Capture-MS Homo sapiens
21 LAMP2 3920
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SEMA4A  
Affinity Capture-MS Homo sapiens
23 SYF2  
Affinity Capture-MS Homo sapiens
24 NDUFB6 4712
Affinity Capture-MS Homo sapiens
25 STX4 6810
Affinity Capture-MS Homo sapiens
26 ARL8B 55207
Affinity Capture-MS Homo sapiens
27 SLC12A2 6558
Affinity Capture-MS Homo sapiens
28 APP 351
Affinity Capture-MS Homo sapiens
29 LILRB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CTSD 1509
Affinity Capture-MS Homo sapiens
31 TMEM154  
Affinity Capture-MS Homo sapiens
32 VRK2 7444
Affinity Capture-MS Homo sapiens
33 HEATR3 55027
Affinity Capture-MS Homo sapiens
34 RPL7A 6130
Affinity Capture-MS Homo sapiens
35 GLG1 2734
Affinity Capture-MS Homo sapiens
36 VKORC1 79001
Affinity Capture-MS Homo sapiens
37 GNS 2799
Affinity Capture-MS Homo sapiens
38 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 STX8 9482
Affinity Capture-MS Homo sapiens
40 STK11IP 114790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HEXB 3074
Affinity Capture-MS Homo sapiens
42 PLBD2 196463
Affinity Capture-MS Homo sapiens
43 CTSZ 1522
Affinity Capture-MS Homo sapiens
44 RAB5B 5869
Affinity Capture-MS Homo sapiens
45 NSUN4  
Affinity Capture-MS Homo sapiens
46 LAMTOR3 8649
Affinity Capture-MS Homo sapiens
47 RHOB 388
Affinity Capture-MS Homo sapiens
48 MYO1B 4430
Affinity Capture-MS Homo sapiens
49 MAN2B1 4125
Affinity Capture-MS Homo sapiens
50 CYR61 3491
Affinity Capture-MS Homo sapiens
51 STXBP3 6814
Affinity Capture-MS Homo sapiens
52 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
53 CD28  
Affinity Capture-MS Homo sapiens
54 SDCBP 6386
Affinity Capture-MS Homo sapiens
55 NDUFA6  
Affinity Capture-MS Homo sapiens
56 TMEM59 9528
Affinity Capture-MS Homo sapiens
57 ATP6AP1 537
Affinity Capture-MS Homo sapiens
58 PWWP2A  
Affinity Capture-MS Homo sapiens
59 LAMTOR1 55004
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 CCDC114  
Affinity Capture-MS Homo sapiens
61 NDFIP1 80762
Affinity Capture-MS Homo sapiens
62 MRPL30  
Affinity Capture-MS Homo sapiens
63 EXTL3 2137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 MAPK8IP3  
Affinity Capture-MS Homo sapiens
65 SLC25A10 1468
Affinity Capture-MS Homo sapiens
66 EFNA5  
Affinity Capture-MS Homo sapiens
67 SEC61A2 55176
Affinity Capture-MS Homo sapiens
68 RTP2  
Affinity Capture-MS Homo sapiens
69 NPC1 4864
Affinity Capture-MS Homo sapiens
70 NDC1 55706
Affinity Capture-MS Homo sapiens
71 RAB14 51552
Affinity Capture-MS Homo sapiens
72 STOM 2040
Affinity Capture-MS Homo sapiens
73 RAB21 23011
Affinity Capture-MS Homo sapiens
74 BRE 9577
Affinity Capture-MS Homo sapiens
75 EIF2B5 8893
Affinity Capture-MS Homo sapiens
76 PPT2  
Affinity Capture-MS Homo sapiens
77 ATPAF1  
Affinity Capture-MS Homo sapiens
78 ACP2 53
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 CTSA 5476
Affinity Capture-MS Homo sapiens
80 SYPL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 NTRK3 4916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 MMAB 326625
Affinity Capture-MS Homo sapiens
83 IL2RA  
Affinity Capture-MS Homo sapiens
84 CTSC 1075
Affinity Capture-MS Homo sapiens
85 GNL3 26354
Affinity Capture-MS Homo sapiens
86 RNF166  
Affinity Capture-MS Homo sapiens
87 SMAD3 4088
Affinity Capture-MS Homo sapiens
88 APOB 338
Affinity Capture-MS Homo sapiens
89 TNFRSF10C  
Affinity Capture-MS Homo sapiens
90 ATP6V1B1 525
Affinity Capture-MS Homo sapiens
91 IFI30  
Affinity Capture-MS Homo sapiens
92 FYN 2534
Affinity Capture-MS Homo sapiens
93 CD63 967
Affinity Capture-MS Homo sapiens
94 SLC2A3 6515
Affinity Capture-MS Homo sapiens
95 FLOT2 2319
Affinity Capture-MS Homo sapiens
96 GTPBP4 23560
Affinity Capture-MS Homo sapiens
97 ATP6V1E1 529
Affinity Capture-MS Homo sapiens
98 GUSB 2990
Affinity Capture-MS Homo sapiens
99 GPRC5A 9052
Affinity Capture-MS Homo sapiens
100 NT5E 4907
Affinity Capture-MS Homo sapiens
101 CYB5B 80777
Affinity Capture-MS Homo sapiens
102 BMS1  
Affinity Capture-MS Homo sapiens
103 TMEM106B 54664
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 HAGH 3029
Affinity Capture-MS Homo sapiens
105 TTYH1  
Affinity Capture-MS Homo sapiens
106 PPAP2C 8612
Affinity Capture-MS Homo sapiens
107 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
108 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 ZDHHC12  
Affinity Capture-MS Homo sapiens
110 GYS1 2997
Affinity Capture-MS Homo sapiens
111 GGH 8836
Affinity Capture-MS Homo sapiens
112 LAMP1 3916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 GCSH 2653
Affinity Capture-MS Homo sapiens
114 PRCP 5547
Affinity Capture-MS Homo sapiens
115 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 XAB2 56949
Affinity Capture-MS Homo sapiens
118 SMAD5 4090
Affinity Capture-MS Homo sapiens
119 GAA 2548
Affinity Capture-MS Homo sapiens
120 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 FTH1 2495
Affinity Capture-MS Homo sapiens
122 PI4K2A 55361
Affinity Capture-MS Homo sapiens
123 SDC2 6383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 MRPL15 29088
Affinity Capture-MS Homo sapiens
125 CD226 10666
Affinity Capture-MS Homo sapiens
126 SMAD1 4086
Affinity Capture-MS Homo sapiens
127 SAAL1 113174
Affinity Capture-MS Homo sapiens
128 SLC2A1 6513
Affinity Capture-MS Homo sapiens
129 IL7R  
Affinity Capture-MS Homo sapiens
130 LDLR 3949
Affinity Capture-MS Homo sapiens
131 JAK1 3716
Affinity Capture-MS Homo sapiens
132 B4GALT7 11285
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 COX6B1 1340
Affinity Capture-MS Homo sapiens
134 RAB9A 9367
Proximity Label-MS Homo sapiens
135 ASPH 444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 PCDHA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 ICAM3 3385
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 MRPL34  
Affinity Capture-MS Homo sapiens
140 LEMD3  
Affinity Capture-MS Homo sapiens
141 FOXK1 221937
Affinity Capture-MS Homo sapiens
142 HIST1H2AJ 8331
Affinity Capture-MS Homo sapiens
143 FLOT1 10211
Affinity Capture-MS Homo sapiens
144 TOMM20 9804
Affinity Capture-MS Homo sapiens
145 NGDN  
Affinity Capture-MS Homo sapiens
146 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
147 GYPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 PPT1 5538
Affinity Capture-MS Homo sapiens
149 TSPAN5 10098
Affinity Capture-MS Homo sapiens
150 SLC38A2 54407
Affinity Capture-MS Homo sapiens
151 GALNS 2588
Affinity Capture-MS Homo sapiens
152 ERLIN1 10613
Affinity Capture-MS Homo sapiens
153 MAP1LC3B 81631
Affinity Capture-MS Homo sapiens
154 ARL8A 127829
Affinity Capture-MS Homo sapiens
155 TSPAN15 23555
Affinity Capture-MS Homo sapiens
156 SQSTM1 8878
Affinity Capture-MS Homo sapiens
157 YARS 8565
Affinity Capture-MS Homo sapiens
158 B4GAT1 11041
Affinity Capture-MS Homo sapiens
159 BOLA3  
Affinity Capture-MS Homo sapiens
160 GBA 2629
Affinity Capture-MS Homo sapiens
161 UBE2D2 7322
Affinity Capture-MS Homo sapiens
162 EVA1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 CLEC12B  
Affinity Capture-MS Homo sapiens
164 PLD3 23646
Affinity Capture-MS Homo sapiens
165 COA6  
Affinity Capture-MS Homo sapiens
166 RAB7A 7879
Affinity Capture-MS Homo sapiens
167 CLTA 1211
Affinity Capture-MS Homo sapiens
168 SDC4 6385
Affinity Capture-MS Homo sapiens
169 TNFRSF9  
Affinity Capture-MS Homo sapiens
170 VAMP5 10791
Affinity Capture-MS Homo sapiens
171 DNASE2 1777
Affinity Capture-MS Homo sapiens
172 RAB5C 5878
Affinity Capture-MS Homo sapiens
173 GOLM1 51280
Affinity Capture-MS Homo sapiens
174 ABHD17B 51104
Affinity Capture-MS Homo sapiens
175 SEC61A1 29927
Affinity Capture-MS Homo sapiens
176 ACTR6  
Affinity Capture-MS Homo sapiens
177 SCARB2 950
Affinity Capture-MS Homo sapiens
178 NDUFS7 374291
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM192 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here