Gene description for MMAB
Gene name methylmalonic aciduria (cobalamin deficiency) cblB type
Gene symbol MMAB
Other names/aliases ATR
CFAP23
cblB
cob
Species Homo sapiens
 Database cross references - MMAB
ExoCarta ExoCarta_326625
Vesiclepedia VP_326625
Entrez Gene 326625
HGNC 19331
MIM 607568
UniProt Q96EY8  
 MMAB identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
 Gene ontology annotations for MMAB
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    corrinoid adenosyltransferase activity GO:0008817 EXP
    corrinoid adenosyltransferase activity GO:0008817 IBA
    corrinoid adenosyltransferase activity GO:0008817 IDA
    corrinoid adenosyltransferase activity GO:0008817 TAS
    transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016765 IDA
    cobalamin binding GO:0031419 IDA
Biological Process
    cobalamin metabolic process GO:0009235 IDA
    cobalamin metabolic process GO:0009235 TAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified MMAB in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MMAB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
2 SLIRP 81892
Proximity Label-MS Homo sapiens
3 DPYSL2 1808
Affinity Capture-MS Homo sapiens
4 ZDHHC5 25921
Affinity Capture-MS Homo sapiens
5 OXLD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SPERT  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 TRUB2  
Proximity Label-MS Homo sapiens
8 ANXA8 653145
Co-fractionation Homo sapiens
9 MTG2  
Proximity Label-MS Homo sapiens
10 NGRN  
Proximity Label-MS Homo sapiens
11 NUDT6  
Affinity Capture-MS Homo sapiens
12 OXNAD1 92106
Affinity Capture-MS Homo sapiens
13 RPUSD4 84881
Proximity Label-MS Homo sapiens
14 DNAJC15  
Proximity Label-MS Homo sapiens
15 MTRF1  
Proximity Label-MS Homo sapiens
16 GFM2 84340
Proximity Label-MS Homo sapiens
17 CCDC90B  
Proximity Label-MS Homo sapiens
18 LRPPRC 10128
Proximity Label-MS Homo sapiens
19 MCU 90550
Proximity Label-MS Homo sapiens
20 CRYZ 1429
Proximity Label-MS Homo sapiens
21 TFAM 7019
Proximity Label-MS Homo sapiens
22 PMPCA 23203
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 C8orf82  
Proximity Label-MS Homo sapiens
24 HINT2 84681
Proximity Label-MS Homo sapiens
25 TMEM18  
Affinity Capture-MS Homo sapiens
26 MPP2 4355
Affinity Capture-MS Homo sapiens
27 MRPS26 64949
Proximity Label-MS Homo sapiens
28 SURF1  
Proximity Label-MS Homo sapiens
29 EXD2  
Proximity Label-MS Homo sapiens
30 FAF1 11124
Affinity Capture-MS Homo sapiens
31 PMPCB 9512
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TACO1  
Proximity Label-MS Homo sapiens
33 FASTKD2  
Proximity Label-MS Homo sapiens
34 VWA8 23078
Proximity Label-MS Homo sapiens
35 MTERF3  
Proximity Label-MS Homo sapiens
36 RBPJ 3516
Affinity Capture-MS Homo sapiens
37 MDH2 4191
Proximity Label-MS Homo sapiens
38 C6orf203  
Proximity Label-MS Homo sapiens
39 DPYSL4 10570
Affinity Capture-MS Homo sapiens
40 COX15 1355
Proximity Label-MS Homo sapiens
41 ZCCHC9  
Affinity Capture-MS Homo sapiens
42 FASTKD5  
Proximity Label-MS Homo sapiens
43 TEKT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PIAS4  
Affinity Capture-MS Homo sapiens
45 TUFM 7284
Proximity Label-MS Homo sapiens
46 HSCB 150274
Proximity Label-MS Homo sapiens
47 SERTAD1  
Affinity Capture-MS Homo sapiens
48 CCDC109B 55013
Proximity Label-MS Homo sapiens
49 GFM1 85476
Proximity Label-MS Homo sapiens
50 C12orf10 60314
Affinity Capture-MS Homo sapiens
51 TMEM192 201931
Affinity Capture-MS Homo sapiens
52 DBT 1629
Affinity Capture-MS Homo sapiens
53 MRPL11 65003
Proximity Label-MS Homo sapiens
54 MTRF1L  
Proximity Label-MS Homo sapiens
55 TMEM70  
Proximity Label-MS Homo sapiens
56 NOTCH2NL 388677
Affinity Capture-MS Homo sapiens
57 OTC 5009
Proximity Label-MS Homo sapiens
58 MRRF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
59 MRPS12  
Proximity Label-MS Homo sapiens
60 MTIF2 4528
Proximity Label-MS Homo sapiens
61 MTIF3  
Proximity Label-MS Homo sapiens
62 CD59 966
Affinity Capture-MS Homo sapiens
63 ECHDC2 55268
Affinity Capture-MS Homo sapiens
64 TRIM68 55128
Affinity Capture-MS Homo sapiens
65 DHX30 22907
Proximity Label-MS Homo sapiens
66 CDK5R1  
Affinity Capture-MS Homo sapiens
67 C12orf65  
Proximity Label-MS Homo sapiens
68 MTG1  
Proximity Label-MS Homo sapiens
69 NUDT8  
Affinity Capture-MS Homo sapiens
70 GNB2 2783
Affinity Capture-MS Homo sapiens
71 FDPS 2224
Affinity Capture-MS Homo sapiens
72 RAB11B 9230
Affinity Capture-MS Homo sapiens
73 ACAD9 28976
Proximity Label-MS Homo sapiens
74 RPIA 22934
Affinity Capture-MS Homo sapiens
75 METTL15  
Proximity Label-MS Homo sapiens
76 MCUR1 63933
Proximity Label-MS Homo sapiens
77 FAM133A 286499
Affinity Capture-MS Homo sapiens
78 TNNT1  
Affinity Capture-MS Homo sapiens
79 CLPP 8192
Proximity Label-MS Homo sapiens
80 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
81 C17orf80 55028
Proximity Label-MS Homo sapiens
82 TSFM 10102
Proximity Label-MS Homo sapiens
83 AUH 549
Proximity Label-MS Homo sapiens
84 DNAJC19 131118
Proximity Label-MS Homo sapiens
85 GPI 2821
Cross-Linking-MS (XL-MS) Homo sapiens
86 DPYSL5  
Affinity Capture-MS Homo sapiens
87 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
88 LONP1 9361
Proximity Label-MS Homo sapiens
89 HADH 3033
Co-fractionation Homo sapiens
90 UBA52 7311
Affinity Capture-MS Homo sapiens
91 PDHA1 5160
Proximity Label-MS Homo sapiens
92 TRMT61B  
Affinity Capture-MS Homo sapiens
93 COX8A  
Proximity Label-MS Homo sapiens
94 C21orf33  
Proximity Label-MS Homo sapiens
95 RAB11FIP1 80223
Affinity Capture-MS Homo sapiens
96 SSBP1 6742
Proximity Label-MS Homo sapiens
97 FASTKD3  
Proximity Label-MS Homo sapiens
98 TBRG4 9238
Proximity Label-MS Homo sapiens
99 AARS2  
Proximity Label-MS Homo sapiens
100 TEFM  
Proximity Label-MS Homo sapiens
101 RPUSD3  
Proximity Label-MS Homo sapiens
102 SERPINB2 5055
Affinity Capture-MS Homo sapiens
103 GRSF1 2926
Proximity Label-MS Homo sapiens
104 C1QBP 708
Proximity Label-MS Homo sapiens
105 CUL7 9820
Affinity Capture-MS Homo sapiens
106 METTL17  
Proximity Label-MS Homo sapiens
107 DDX28  
Proximity Label-MS Homo sapiens
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