Gene description for MMAB
Gene name methylmalonic aciduria (cobalamin deficiency) cblB type
Gene symbol MMAB
Other names/aliases ATR
CFAP23
cblB
cob
Species Homo sapiens
 Database cross references - MMAB
ExoCarta ExoCarta_326625
Entrez Gene 326625
HGNC 19331
MIM 607568
UniProt Q96EY8  
 MMAB identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MMAB
Molecular Function
    cob(I)yrinic acid a,c-diamide adenosyltransferase activity GO:0008817 TAS
    ATP binding GO:0005524 IEA
Biological Process
    cobalamin biosynthetic process GO:0009236 IEA
    vitamin metabolic process GO:0006766 TAS
    cobalamin metabolic process GO:0009235 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified MMAB in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MMAB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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