Gene description for HADH
Gene name hydroxyacyl-CoA dehydrogenase
Gene symbol HADH
Other names/aliases HAD
HADH1
HADHSC
HCDH
HHF4
MSCHAD
SCHAD
Species Homo sapiens
 Database cross references - HADH
ExoCarta ExoCarta_3033
Entrez Gene 3033
HGNC 4799
MIM 601609
UniProt Q16836  
 HADH identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for HADH
Molecular Function
    3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 TAS
    NAD+ binding GO:0070403 IEA
Biological Process
    cellular lipid metabolic process GO:0044255 TAS
    response to drug GO:0042493 IEA
    small molecule metabolic process GO:0044281 TAS
    negative regulation of insulin secretion GO:0046676 IEA
    response to activity GO:0014823 IEA
    response to insulin GO:0032868 IEA
    fatty acid beta-oxidation GO:0006635 TAS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
 Experiment description of studies that identified HADH in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HADH
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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