Gene description for CLIC3
Gene name chloride intracellular channel 3
Gene symbol CLIC3
Other names/aliases -
Species Homo sapiens
 Database cross references - CLIC3
ExoCarta ExoCarta_9022
Entrez Gene 9022
HGNC 2064
MIM 606533
UniProt O95833  
 CLIC3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CLIC3
Molecular Function
    voltage-gated ion channel activity GO:0005244 IEA
    protein binding GO:0005515 IPI
    chloride channel activity GO:0005254 IMP
Biological Process
    signal transduction GO:0007165 TAS
    chloride transport GO:0006821 IMP
    chloride transmembrane transport GO:1902476 IMP
    regulation of ion transmembrane transport GO:0034765 IEA
Subcellular Localization
    chloride channel complex GO:0034707 IEA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified CLIC3 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CLIC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK15  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CLIC3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here