Gene description for UBE2R2
Gene name ubiquitin-conjugating enzyme E2R 2
Gene symbol UBE2R2
Other names/aliases CDC34B
E2-CDC34B
UBC3B
Species Homo sapiens
 Database cross references - UBE2R2
ExoCarta ExoCarta_54926
Entrez Gene 54926
HGNC 19907
MIM 612506
UniProt Q712K3  
 UBE2R2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for UBE2R2
Molecular Function
    ubiquitin protein ligase binding GO:0031625 IBA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin conjugating enzyme activity GO:0061631 IDA
    ligase activity GO:0016874 IEA
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    ubiquitin-protein transferase activity GO:0004842 IDA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    protein K48-linked ubiquitination GO:0070936 IDA
    protein monoubiquitination GO:0006513 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified UBE2R2 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for UBE2R2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BTRC 8945
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which UBE2R2 is involved
PathwayEvidenceSource
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome





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