Gene description for BTRC
Gene name	beta-transducin repeat containing E3 ubiquitin protein ligase
Gene symbol	BTRC
Other names/aliases	BETA-TRCP FBW1A FBXW1 FBXW1A FWD1 bTrCP bTrCP1 betaTrCP
Species	Homo sapiens
Database cross references - BTRC
ExoCarta	ExoCarta_8945
Vesiclepedia	VP_8945
Entrez Gene	8945
HGNC	1144
MIM	603482
UniProt	Q9Y297
BTRC identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for BTRC

Molecular Function     protein binding GO:0005515 IPI     beta-catenin binding GO:0008013 IDA     ligase activity GO:0016874 IEA     protein phosphorylated amino acid binding GO:0045309 IEA     protein dimerization activity GO:0046983 IEA     ubiquitin protein ligase activity GO:0061630 IEA     ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA     ubiquitin ligase activator activity GO:1990757 IDA Biological Process     protein polyubiquitination GO:0000209 IDA     protein polyubiquitination GO:0000209 IMP     protein dephosphorylation GO:0006470 ISS     ubiquitin-dependent protein catabolic process GO:0006511 IDA     signal transduction GO:0007165 TAS     Wnt signaling pathway GO:0016055 IEA     protein ubiquitination GO:0016567 IDA     protein ubiquitination GO:0016567 IMP     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IDA     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISS     protein destabilization GO:0031648 IMP     mammary gland epithelial cell proliferation GO:0033598 IEA     non-canonical NF-kappaB signal transduction GO:0038061 IDA     regulation of circadian rhythm GO:0042752 IDA     positive regulation of circadian rhythm GO:0042753 ISS     regulation of canonical NF-kappaB signal transduction GO:0043122 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     negative regulation of DNA-binding transcription factor activity GO:0043433 TAS     positive regulation of proteolysis GO:0045862 IMP     negative regulation of smoothened signaling pathway GO:0045879 TAS     negative regulation of DNA-templated transcription GO:0045892 IMP     positive regulation of DNA-templated transcription GO:0045893 ISS     rhythmic process GO:0048511 IEA     negative regulation of T cell receptor signaling pathway GO:0050860 IDA     regulation of cell cycle GO:0051726 IEA     branching involved in mammary gland duct morphogenesis GO:0060444 IEA     regulation of canonical Wnt signaling pathway GO:0060828 IC     regulation of proteasomal protein catabolic process GO:0061136 IEA     protein K48-linked ubiquitination GO:0070936 IDA     cellular response to organic cyclic compound GO:0071407 IEA     positive regulation of ubiquitin protein ligase activity GO:1904668 IDA Subcellular Localization     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IC     cytosol GO:0005829 TAS     SCF ubiquitin ligase complex GO:0019005 IDA