Gene description for BTRC
Gene name	beta-transducin repeat containing E3 ubiquitin protein ligase
Gene symbol	BTRC
Other names/aliases	BETA-TRCP FBW1A FBXW1 FBXW1A FWD1 bTrCP bTrCP1 betaTrCP
Species	Homo sapiens
Database cross references - BTRC
ExoCarta	ExoCarta_8945
Entrez Gene	8945
HGNC	1144
MIM	603482
UniProt	Q9Y297
BTRC identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for BTRC

Molecular Function     protein dimerization activity GO:0046983 IEA     ubiquitin-protein transferase activity GO:0004842 IDA     ligase activity GO:0016874 IEA     beta-catenin binding GO:0008013 IEA     protein binding GO:0005515 IPI     protein phosphorylated amino acid binding GO:0045309 IEA Biological Process     regulation of proteasomal protein catabolic process GO:0061136 IEA     branching involved in mammary gland duct morphogenesis GO:0060444 IEA     ubiquitin-dependent protein catabolic process GO:0006511 IDA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     cellular response to organic cyclic compound GO:0071407 IEA     mammary gland epithelial cell proliferation GO:0033598 IEA     circadian rhythm GO:0007623 TAS     mitotic cell cycle GO:0000278 TAS     G2/M transition of mitotic cell cycle GO:0000086 TAS     negative regulation of smoothened signaling pathway GO:0045879 TAS     Wnt signaling pathway GO:0016055 IEA     positive regulation of circadian rhythm GO:0042753 ISS     regulation of circadian rhythm GO:0042752 IDA     positive regulation of proteolysis GO:0045862 IMP     negative regulation of transcription, DNA-templated GO:0045892 IMP     regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS     positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS     innate immune response GO:0045087 TAS     positive regulation of transcription, DNA-templated GO:0045893 ISS     regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 IEA     protein ubiquitination GO:0016567 IDA     protein polyubiquitination GO:0000209 IEA     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IBA     protein dephosphorylation GO:0006470 ISS     viral process GO:0016032 TAS     anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 TAS     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 TAS     protein destabilization GO:0031648 IMP     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     signal transduction GO:0007165 TAS Subcellular Localization     nucleoplasm GO:0005654 TAS     SCF ubiquitin ligase complex GO:0019005 IDA     cytosol GO:0005829 TAS