Gene description for ZNF395
Gene name zinc finger protein 395
Gene symbol ZNF395
Other names/aliases HDBP-2
HDBP2
HDRF-2
PBF
PRF-1
PRF1
Si-1-8-14
Species Homo sapiens
 Database cross references - ZNF395
ExoCarta ExoCarta_55893
Vesiclepedia VP_55893
Entrez Gene 55893
HGNC 18737
MIM 609494
UniProt Q9H8N7  
 ZNF395 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZNF395
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of DNA-templated transcription GO:0006355 IC
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified ZNF395 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZNF395
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 YWHAQ 10971
Affinity Capture-MS Homo sapiens
4 HDAC1 3065
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
7 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
9 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
10 SAP30 8819
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 YWHAB 7529
Affinity Capture-MS Homo sapiens
13 WASL 8976
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF395 is involved
No pathways found





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