Gene description for SAP30
Gene name Sin3A-associated protein, 30kDa
Gene symbol SAP30
Other names/aliases -
Species Homo sapiens
 Database cross references - SAP30
ExoCarta ExoCarta_8819
Entrez Gene 8819
HGNC 10532
MIM 603378
UniProt O75446  
 SAP30 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SAP30
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    transcription corepressor activity GO:0003714 IDA
    DNA binding GO:0003677 IEA
Biological Process
    negative regulation of gene expression, epigenetic GO:0045814 TAS
    chromatin organization GO:0006325 TAS
    skeletal muscle cell differentiation GO:0035914 IEA
    transcription, DNA-templated GO:0006351 IEA
    gene expression GO:0010467 TAS
    regulation of transcription, DNA-templated GO:0006355 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    regulation of gene expression, epigenetic GO:0040029 TAS
Subcellular Localization
    histone deacetylase complex GO:0000118 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified SAP30 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SAP30
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTA2 9219
Co-purification Homo sapiens
2 HDAC1 3065
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 RBBP7 5931
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
4 CIR  
Two-hybrid Homo sapiens
5 NCOR1  
Invitro Homo sapiens
Co-purification Homo sapiens
6 PHF12  
Affinity Capture-Western Homo sapiens
7 HDAC2 3066
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
8 ING1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
9 YY1 7528
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 SIN3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
11 SIN3B  
Co-purification Homo sapiens
12 NCOR2  
Invitro Homo sapiens
Co-purification Homo sapiens
13 RBBP4 5928
Invitro Homo sapiens
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SAP30 is involved
PathwayEvidenceSource
HDACs deacetylate histones TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome





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