Gene description for HMGXB4
Gene name HMG box domain containing 4
Gene symbol HMGXB4
Other names/aliases HMG2L1
HMGBCG
THC211630
Species Homo sapiens
 Database cross references - HMGXB4
ExoCarta ExoCarta_10042
Vesiclepedia VP_10042
Entrez Gene 10042
HGNC 5003
MIM 604702
UniProt Q9UGU5  
 HMGXB4 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for HMGXB4
Molecular Function
    chromatin binding GO:0003682 IBA
    DNA binding GO:0003677 IEA
Biological Process
    chromatin remodeling GO:0006338 IBA
    negative regulation of Wnt signaling pathway GO:0030178 ISS
    regulation of transcription, DNA-templated GO:0006355 IBA
    Wnt signaling pathway GO:0016055 IEA
    endosome to lysosome transport GO:0008333 NAS
Subcellular Localization
    NURF complex GO:0016589 IDA
 Experiment description of studies that identified HMGXB4 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for HMGXB4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HMGXB4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here