Gene description for YY1
Gene name YY1 transcription factor
Gene symbol YY1
Other names/aliases DELTA
INO80S
NF-E1
UCRBP
YIN-YANG-1
Species Homo sapiens
 Database cross references - YY1
ExoCarta ExoCarta_7528
Vesiclepedia VP_7528
Entrez Gene 7528
HGNC 12856
MIM 600013
UniProt P25490  
 YY1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for YY1
Molecular Function
    four-way junction DNA binding GO:0000400 IDA
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IMP
    DNA-binding transcription repressor activity GO:0001217 TAS
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISS
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 IEA
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
    SMAD binding GO:0046332 IMP
    metal ion binding GO:0046872 IEA
    DNA-binding transcription factor binding GO:0140297 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    telomere maintenance GO:0000723 ISO
    double-strand break repair via homologous recombination GO:0000724 IMP
    regulation of DNA replication GO:0006275 IMP
    regulation of DNA repair GO:0006282 ISO
    chromatin remodeling GO:0006338 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    RNA localization GO:0006403 IEA
    DNA damage response GO:0006974 IMP
    spermatogenesis GO:0007283 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    response to UV-C GO:0010225 IMP
    positive regulation of gene expression GO:0010628 IEA
    negative regulation of gene expression GO:0010629 IMP
    B cell differentiation GO:0030183 IEA
    negative regulation of interferon-beta production GO:0032688 IDA
    regulation of chromosome organization GO:0033044 IMP
    cellular response to UV GO:0034644 IMP
    response to prostaglandin F GO:0034696 IEA
    positive regulation of DNA repair GO:0045739 ISO
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IC
    regulation of embryonic development GO:0045995 ISO
    camera-type eye morphogenesis GO:0048593 IEA
    regulation of cell cycle GO:0051726 IMP
    regulation of DNA strand elongation GO:0060382 IMP
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 IEA
    cellular response to interleukin-1 GO:0071347 IEA
    immunoglobulin heavy chain V-D-J recombination GO:0071707 IEA
    negative regulation of miRNA transcription GO:1902894 IEA
    positive regulation of telomere maintenance in response to DNA damage GO:1904507 ISO
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IBA
    chromatin silencing complex GO:0005677 IEA
    nuclear matrix GO:0016363 IEA
    Ino80 complex GO:0031011 IDA
    PcG protein complex GO:0031519 IBA
 Experiment description of studies that identified YY1 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for YY1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDCA2 157313
Proximity Label-MS Homo sapiens
2 HDAC4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 ZNF24  
Co-fractionation Homo sapiens
4 HDAC2 3066
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 Ruvbl1 56505
Affinity Capture-MS Mus musculus
6 RCL1 10171
Affinity Capture-MS Homo sapiens
7 CABIN1  
Proximity Label-MS Homo sapiens
8 INO80  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ADSSL1  
Affinity Capture-MS Homo sapiens
10 PLEKHF2 79666
Two-hybrid Homo sapiens
11 FAM60A  
Proximity Label-MS Homo sapiens
12 ZZZ3  
Proximity Label-MS Homo sapiens
13 BRD2  
Affinity Capture-MS Homo sapiens
14 THOC7 80145
Proximity Label-MS Homo sapiens
15 PRPF40A 55660
Affinity Capture-MS Homo sapiens
16 TAF1  
Proximity Label-MS Homo sapiens
17 ELF4 2000
Proximity Label-MS Homo sapiens
18 CENPA  
Proximity Label-MS Homo sapiens
19 APEX1 328
Proximity Label-MS Homo sapiens
20 ZNF687  
Proximity Label-MS Homo sapiens
21 HDAC3 8841
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
22 KRTAP2-4  
Two-hybrid Homo sapiens
23 CPSF7 79869
Affinity Capture-MS Homo sapiens
24 UCHL5 51377
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
25 MECP2 4204
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 WDR5 11091
Proximity Label-MS Homo sapiens
27 MTA2 9219
Reconstituted Complex Homo sapiens
28 TFAP2A  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
29 HEXIM1 10614
Affinity Capture-MS Homo sapiens
30 AURKA 6790
Reconstituted Complex Homo sapiens
31 ATF7IP 55729
Proximity Label-MS Homo sapiens
32 ATF7  
Reconstituted Complex Homo sapiens
33 MEPCE 56257
Affinity Capture-MS Homo sapiens
34 C17orf49 124944
Proximity Label-MS Homo sapiens
35 ZMYM3  
Proximity Label-MS Homo sapiens
36 SLX4  
Affinity Capture-MS Homo sapiens
37 GTF3C2  
Proximity Label-MS Homo sapiens
38 SPANXN2  
Affinity Capture-MS Homo sapiens
39 CCNT1  
Affinity Capture-MS Homo sapiens
40 ID2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CD3EAP  
Proximity Label-MS Homo sapiens
42 TWIST1  
Reconstituted Complex Homo sapiens
43 CYSRT1 375791
Two-hybrid Homo sapiens
44 RING1 6015
Co-fractionation Homo sapiens
45 BRD7  
Proximity Label-MS Homo sapiens
46 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
47 HSPA5 3309
Co-localization Homo sapiens
48 NIPA2 81614
Affinity Capture-MS Homo sapiens
49 GTF3C3 9330
Proximity Label-MS Homo sapiens
50 ASXL2  
Proximity Label-MS Homo sapiens
51 RELA 5970
Co-fractionation Homo sapiens
52 KMT2E  
Affinity Capture-MS Homo sapiens
53 CUL3 8452
Affinity Capture-MS Homo sapiens
54 KANSL2  
Proximity Label-MS Homo sapiens
55 ZNF512  
Proximity Label-MS Homo sapiens
56 ESM1 11082
Two-hybrid Homo sapiens
57 MFAP1  
Affinity Capture-MS Homo sapiens
58 RPA3 6119
Proximity Label-MS Homo sapiens
59 ZMYND8 23613
Proximity Label-MS Homo sapiens
60 SPRY1 10252
Two-hybrid Homo sapiens
61 RPL35A 6165
Affinity Capture-MS Homo sapiens
62 HSPA4 3308
Co-purification Homo sapiens
63 KANSL3  
Proximity Label-MS Homo sapiens
64 LYAR 55646
Affinity Capture-MS Homo sapiens
65 KRTAP10-5  
Two-hybrid Homo sapiens
66 PRKDC 5591
Co-purification Homo sapiens
67 DNMT3L  
Reconstituted Complex Homo sapiens
68 KRTAP1-5  
Two-hybrid Homo sapiens
69 NUDT21 11051
Affinity Capture-MS Homo sapiens
70 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
71 FASN 2194
Positive Genetic Homo sapiens
72 KAT8  
Proximity Label-MS Homo sapiens
73 ARID2  
Proximity Label-MS Homo sapiens
74 RBM25 58517
Affinity Capture-MS Homo sapiens
75 RUVBL2 10856
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
76 KMT2B  
Proximity Label-MS Homo sapiens
77 KDM1B  
Proximity Label-MS Homo sapiens
78 FOXB1  
Affinity Capture-MS Homo sapiens
79 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
80 SSBP1 6742
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PWP1 11137
Proximity Label-MS Homo sapiens
82 NCL 4691
Co-fractionation Homo sapiens
83 PCGF6  
Proximity Label-MS Homo sapiens
84 IL10 3586
Two-hybrid Homo sapiens
85 LIN54  
Proximity Label-MS Homo sapiens
86 EHMT1  
Proximity Label-MS Homo sapiens
87 RPL23A 6147
Affinity Capture-MS Homo sapiens
88 NFIC 4782
Reconstituted Complex Homo sapiens
89 GATAD1  
Proximity Label-MS Homo sapiens
90 SMURF2 64750
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
91 MORC2  
Proximity Label-MS Homo sapiens
92 SPRTN  
Affinity Capture-MS Homo sapiens
93 ELF1 1997
Proximity Label-MS Homo sapiens
94 TRRAP 8295
Proximity Label-MS Homo sapiens
95 KLF9 687
Proximity Label-MS Homo sapiens
96 RBM15B  
Affinity Capture-MS Homo sapiens
97 PPIL4  
Affinity Capture-MS Homo sapiens
98 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
99 POGZ 23126
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 PRPF38A 84950
Affinity Capture-MS Homo sapiens
101 NOP56 10528
Proximity Label-MS Homo sapiens
102 JUND 3727
Affinity Capture-Western Homo sapiens
103 ASXL1  
Proximity Label-MS Homo sapiens
104 MBIP  
Proximity Label-MS Homo sapiens
105 SRCAP  
Proximity Label-MS Homo sapiens
106 PRC1 9055
Affinity Capture-MS Homo sapiens
107 ARID4B  
Proximity Label-MS Homo sapiens
108 NPM1 4869
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
109 F9 2158
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 KRTAP4-2  
Two-hybrid Homo sapiens
111 MGA  
Proximity Label-MS Homo sapiens
112 MSL2  
Affinity Capture-MS Homo sapiens
113 ZNF644  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 DDX6 1656
Affinity Capture-MS Homo sapiens
115 WIZ 58525
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 SETD1A 9739
Proximity Label-MS Homo sapiens
117 TACO1  
Affinity Capture-MS Homo sapiens
118 KANSL1  
Proximity Label-MS Homo sapiens
119 GTF2I 2969
Affinity Capture-MS Homo sapiens
120 Hoxa11  
Two-hybrid Mus musculus
121 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
122 NFRKB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 RBM28 55131
Proximity Label-MS Homo sapiens
124 ZMYM1 79830
Proximity Label-MS Homo sapiens
125 NFIX 4784
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
126 TRIM24  
Proximity Label-MS Homo sapiens
127 IFI27L1  
Affinity Capture-MS Homo sapiens
128 TFDP1  
Proximity Label-MS Homo sapiens
129 ZHX3  
Proximity Label-MS Homo sapiens
130 NFIA 4774
Proximity Label-MS Homo sapiens
131 LHX3  
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
132 BPTF 2186
Proximity Label-MS Homo sapiens
133 TOX4  
Affinity Capture-MS Homo sapiens
134 CCDC101  
Proximity Label-MS Homo sapiens
135 BCL6  
Affinity Capture-MS Homo sapiens
136 KLF12  
Proximity Label-MS Homo sapiens
137 RAD21 5885
Proximity Label-MS Homo sapiens
138 FAM76A  
Affinity Capture-MS Homo sapiens
139 C7orf50 84310
Proximity Label-MS Homo sapiens
140 YEATS4  
Proximity Label-MS Homo sapiens
141 FAM76B  
Affinity Capture-MS Homo sapiens
142 KRTAP1-3  
Two-hybrid Homo sapiens
143 SMCHD1 23347
Proximity Label-MS Homo sapiens
144 SMARCAD1  
Affinity Capture-MS Homo sapiens
145 POP1 10940
Affinity Capture-MS Homo sapiens
146 KRTAP10-8  
Two-hybrid Homo sapiens
147 SREBF1 6720
Reconstituted Complex Homo sapiens
148 BRD8 10902
Proximity Label-MS Homo sapiens
149 CSRP2BP  
Proximity Label-MS Homo sapiens
150 FOXL1  
Affinity Capture-MS Homo sapiens
151 SMAD1 4086
Reconstituted Complex Homo sapiens
152 DMAP1 55929
Proximity Label-MS Homo sapiens
153 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
154 TADA2A  
Proximity Label-MS Homo sapiens
155 MYC  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
156 KRTAP2-3  
Two-hybrid Homo sapiens
157 EHMT2 10919
Proximity Label-MS Homo sapiens
158 ACTR8 93973
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 HNF1B  
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
160 FKBP3 2287
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
161 BMI1  
Affinity Capture-MS Homo sapiens
162 MRPS17 51373
Proximity Label-MS Homo sapiens
163 MYB  
Proximity Label-MS Homo sapiens
164 ARHGEF15  
Affinity Capture-MS Homo sapiens
165 FHL2 2274
Two-hybrid Homo sapiens
166 TAF4 6874
Proximity Label-MS Homo sapiens
167 SUZ12  
Affinity Capture-MS Homo sapiens
168 TAF6 6878
Proximity Label-MS Homo sapiens
169 Ruvbl2 20174
Affinity Capture-MS Mus musculus
170 GRN 2896
Two-hybrid Homo sapiens
171 TERF2  
Affinity Capture-MS Homo sapiens
172 PARP1 142
Proximity Label-MS Homo sapiens
173 ILF3 3609
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
174 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
175 FOXJ2  
Affinity Capture-MS Homo sapiens
176 SF3B4 10262
Affinity Capture-MS Homo sapiens
177 SLC39A7 7922
Two-hybrid Homo sapiens
178 RIF1  
Proximity Label-MS Homo sapiens
179 ACTR6  
Proximity Label-MS Homo sapiens
180 C1orf35  
Affinity Capture-MS Homo sapiens
181 THAP11 57215
Proximity Label-MS Homo sapiens
182 KLF16  
Proximity Label-MS Homo sapiens
183 NOTCH1 4851
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
184 TCF3  
Affinity Capture-MS Homo sapiens
185 BCCIP 56647
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
186 BRD1 23774
Affinity Capture-MS Homo sapiens
187 DDX42 11325
Affinity Capture-MS Homo sapiens
188 EP300 2033
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
189 PRMT1 3276
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
190 ZNF830  
Co-fractionation Homo sapiens
191 KRTAP12-3  
Two-hybrid Homo sapiens
192 CBX1 10951
Proximity Label-MS Homo sapiens
193 MBD6  
Proximity Label-MS Homo sapiens
194 FEV  
Proximity Label-MS Homo sapiens
195 HOXA11  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
196 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
197 RPS19 6223
Affinity Capture-MS Homo sapiens
198 MDFI  
Two-hybrid Homo sapiens
199 PPP1R10  
Affinity Capture-MS Homo sapiens
200 NFKB1 4790
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
201 CAPZB 832
Affinity Capture-MS Homo sapiens
202 RUVBL1 8607
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens