Gene description for YY1
Gene name YY1 transcription factor
Gene symbol YY1
Other names/aliases DELTA
INO80S
NF-E1
UCRBP
YIN-YANG-1
Species Homo sapiens
 Database cross references - YY1
ExoCarta ExoCarta_7528
Entrez Gene 7528
HGNC 12856
MIM 600013
UniProt P25490  
 YY1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for YY1
Molecular Function
    transcription corepressor activity GO:0003714 TAS
    transcription coactivator activity GO:0003713 TAS
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    SMAD binding GO:0046332 IMP
    RNA binding GO:0003723 IDA
    four-way junction DNA binding GO:0000400 IDA
    enhancer sequence-specific DNA binding GO:0001158 IMP
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 TAS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 ISS
    DNA binding GO:0003677 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
Biological Process
    response to UV-C GO:0010225 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    chromosome organization GO:0051276 IEA
    response to prostaglandin F GO:0034696 IEA
    cell differentiation GO:0030154 IEA
    double-strand break repair via homologous recombination GO:0000724 IMP
    negative regulation of gene expression GO:0010629 IMP
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of gene expression GO:0010628 IEA
    spermatogenesis GO:0007283 IEA
    RNA localization GO:0006403 IEA
    cellular response to UV GO:0034644 IMP
    cellular response to DNA damage stimulus GO:0006974 IMP
    camera-type eye morphogenesis GO:0048593 IEA
    anterior/posterior pattern specification GO:0009952 IEA
Subcellular Localization
    nuclear matrix GO:0016363 IEA
    nucleus GO:0005634 IMP
    PcG protein complex GO:0031519 IEA
    Ino80 complex GO:0031011 IDA
    transcription factor complex GO:0005667 IEA
 Experiment description of studies that identified YY1 in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for YY1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SP1  
Affinity Capture-Western Homo sapiens
2 EP300 2033
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 HDAC1 3065
Reconstituted Complex Homo sapiens
4 FKBP3 2287
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
5 SREBF1 6720
Reconstituted Complex Homo sapiens
6 E2F2 1870
Affinity Capture-MS Homo sapiens
7 HDAC3 8841
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 HDAC2 3066
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 PCAF  
Biochemical Activity Homo sapiens
10 YAF2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
11 MYC  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 MTA2 9219
Reconstituted Complex Homo sapiens
13 SAP30 8819
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
14 NOTCH1 4851
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 RYBP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
16 ATF6  
Invivo Homo sapiens
17 FKBP1A 2280
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
18 CREB1  
Affinity Capture-MS Homo sapiens
19 GTF2I 2969
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which YY1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here