Gene description for MEPCE
Gene name methylphosphate capping enzyme
Gene symbol MEPCE
Other names/aliases BCDIN3
Species Homo sapiens
 Database cross references - MEPCE
ExoCarta ExoCarta_56257
Vesiclepedia VP_56257
Entrez Gene 56257
HGNC 20247
MIM 611478
UniProt Q7L2J0  
 MEPCE identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for MEPCE
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IPI
    protein binding GO:0005515 IPI
    O-methyltransferase activity GO:0008171 IBA
    RNA methyltransferase activity GO:0008173 IBA
    RNA methyltransferase activity GO:0008173 IDA
    RNA methyltransferase activity GO:0008173 IMP
    S-adenosylmethionine-dependent methyltransferase activity GO:0008757 IDA
    snRNA binding GO:0017069 IBA
    7SK snRNA binding GO:0097322 IDA
    RNA 5'-gamma-phosphate methyltransferase activity GO:1990276 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    RNA methylation GO:0001510 IDA
    snRNA metabolic process GO:0016073 IDA
    snRNA modification GO:0040031 IBA
    snRNA modification GO:0040031 IDA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA
    positive regulation of protein localization to Cajal body GO:1904871 IDA
    positive regulation of snRNA transcription by RNA polymerase II GO:1905382 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    7SK snRNP GO:0120259 IDA
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified MEPCE in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MEPCE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 EPB41L2 2037
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
6 METTL17  
Affinity Capture-MS Homo sapiens
7 ISG15 9636
Affinity Capture-MS Homo sapiens
8 TUBA8 51807
Affinity Capture-MS Homo sapiens
9 AKAP7 9465
Affinity Capture-MS Homo sapiens
10 CHMP3 51652
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SNRPG 6637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CDK11B 984
Affinity Capture-MS Homo sapiens
13 SNRPE 6635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ANP32A 8125
Affinity Capture-MS Homo sapiens
15 ZNF346  
Affinity Capture-MS Homo sapiens
16 KPNA1 3836
Affinity Capture-MS Homo sapiens
17 YTHDF1 54915
Affinity Capture-MS Homo sapiens
18 RBM15B  
Affinity Capture-MS Homo sapiens
19 PPIL4  
Affinity Capture-MS Homo sapiens
20 TRIM26 7726
Affinity Capture-MS Homo sapiens
21 RPA2 6118
Proximity Label-MS Homo sapiens
22 PRPF38A 84950
Affinity Capture-MS Homo sapiens
23 GLB1 2720
Affinity Capture-MS Homo sapiens
24 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
25 THRAP3 9967
Affinity Capture-MS Homo sapiens
26 ACTC1 70
Proximity Label-MS Homo sapiens
27 NOP56 10528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RPS3 6188
Affinity Capture-MS Homo sapiens
29 UTP23  
Affinity Capture-MS Homo sapiens
30 RPL10 6134
Affinity Capture-MS Homo sapiens
31 BYSL 705
Affinity Capture-MS Homo sapiens
32 LSM4 25804
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 BRD2  
Affinity Capture-MS Homo sapiens
34 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
35 CCT4 10575
Affinity Capture-MS Homo sapiens
36 PRPF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PNMAL1  
Affinity Capture-MS Homo sapiens
38 CAND1 55832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HNRNPR 10236
Affinity Capture-MS Homo sapiens
40 ARID3B  
Affinity Capture-MS Homo sapiens
41 PPP1R10  
Affinity Capture-MS Homo sapiens
42 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SNRPD2 6633
Affinity Capture-MS Homo sapiens
44 LSM5 23658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 HSPA5 3309
Affinity Capture-MS Homo sapiens
46 ILF2 3608
Affinity Capture-MS Homo sapiens
47 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SDE2  
Affinity Capture-MS Homo sapiens
49 PCBP2 5094
Affinity Capture-MS Homo sapiens
50 CAPZB 832
Affinity Capture-MS Homo sapiens
51 DDX23 9416
Affinity Capture-MS Homo sapiens
52 RUVBL1 8607
Affinity Capture-MS Homo sapiens
53 SNRNP70 6625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 TRIM28 10155
Affinity Capture-MS Homo sapiens
55 YWHAZ 7534
Affinity Capture-MS Homo sapiens
56 SUV420H2  
Affinity Capture-MS Homo sapiens
57 HSPA2 3306
Affinity Capture-MS Homo sapiens
58 KIF23 9493
Affinity Capture-MS Homo sapiens
59 UBE2O 63893
Affinity Capture-MS Homo sapiens
60 ATXN2L 11273
Affinity Capture-MS Homo sapiens
61 ZNF524  
Affinity Capture-MS Homo sapiens
62 USP39 10713
Affinity Capture-MS Homo sapiens
63 CHCHD2  
Affinity Capture-MS Homo sapiens
64 KIF5B 3799
Affinity Capture-MS Homo sapiens
65 ANP32B 10541
Affinity Capture-MS Homo sapiens
66 RFC3 5983
Affinity Capture-MS Homo sapiens
67 CPSF7 79869
Affinity Capture-MS Homo sapiens
68 NPM1 4869
Affinity Capture-MS Homo sapiens
69 ZMYND11 10771
Affinity Capture-MS Homo sapiens
70 BRPF3  
Affinity Capture-MS Homo sapiens
71 AK2 204
Affinity Capture-MS Homo sapiens
72 RPS9 6203
Affinity Capture-MS Homo sapiens
73 MAGED2 10916
Affinity Capture-MS Homo sapiens
74 SRSF3 6428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 GTF2F1 2962
Affinity Capture-MS Homo sapiens
76 TBC1D15 64786
Affinity Capture-MS Homo sapiens
77 TULP3 7289
Affinity Capture-MS Homo sapiens
78 SNRPD3 6634
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 SRP68 6730
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 U2AF1 7307
Affinity Capture-MS Homo sapiens
81 ATG16L1 55054
Affinity Capture-MS Homo sapiens
82 DDX6 1656
Affinity Capture-MS Homo sapiens
83 FBL 2091
Affinity Capture-MS Homo sapiens
84 HSPA6 3310
Affinity Capture-MS Homo sapiens
85 DOCK1 1793
Affinity Capture-MS Homo sapiens
86 MECP2 4204
Affinity Capture-MS Homo sapiens
87 MYCN  
Affinity Capture-MS Homo sapiens
88 CSNK1D 1453
Affinity Capture-MS Homo sapiens
89 TAF2  
Affinity Capture-MS Homo sapiens
90 CSNK2B 1460
Affinity Capture-MS Homo sapiens
91 RPS2 6187
Affinity Capture-MS Homo sapiens
92 KIF14 9928
Affinity Capture-MS Homo sapiens
93 RPS14 6208
Affinity Capture-MS Homo sapiens
94 LIN28A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 LSM2 57819
Affinity Capture-MS Homo sapiens
96 CCT2 10576
Affinity Capture-MS Homo sapiens
97 GTF2I 2969
Affinity Capture-MS Homo sapiens
98 HEXIM1 10614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 E2F4  
Affinity Capture-MS Homo sapiens
100 XPO1 7514
Affinity Capture-MS Homo sapiens
101 UFL1 23376
Affinity Capture-MS Homo sapiens
102 SRP9 6726
Affinity Capture-MS Homo sapiens
103 KPNA3 3839
Affinity Capture-MS Homo sapiens
104 RN7SK 125050
Biochemical Activity Homo sapiens
105 JUN 3725
Affinity Capture-MS Homo sapiens
106 HNRNPA0 10949
Affinity Capture-MS Homo sapiens
107 PRPF8 10594
Affinity Capture-MS Homo sapiens
108 DDX21 9188
Affinity Capture-MS Homo sapiens
109 LIN28B  
Affinity Capture-MS Homo sapiens
110 TUT1  
Affinity Capture-MS Homo sapiens
111 RFC5 5985
Affinity Capture-MS Homo sapiens
112 TOX4  
Affinity Capture-MS Homo sapiens
113 PARK2  
Affinity Capture-MS Homo sapiens
114 CCAR2 57805
Affinity Capture-MS Homo sapiens
115 DRG1 4733
Affinity Capture-MS Homo sapiens
116 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 YBX2 51087
Affinity Capture-MS Homo sapiens
118 NONO 4841
Affinity Capture-MS Homo sapiens
119 DTYMK 1841
Affinity Capture-MS Homo sapiens
120 SRSF6 6431
Affinity Capture-MS Homo sapiens
121 ARHGEF1 9138
Affinity Capture-MS Homo sapiens
122 UBE2M 9040
Affinity Capture-MS Homo sapiens
123 PPIH 10465
Affinity Capture-MS Homo sapiens
124 SNRNP200 23020
Affinity Capture-MS Homo sapiens
125 CIAO1 9391
Affinity Capture-MS Homo sapiens
126 RPL5 6125
Affinity Capture-MS Homo sapiens
127 SNRPB 6628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 SNIP1  
Affinity Capture-MS Homo sapiens
129 Srp72  
Affinity Capture-MS Mus musculus
130 SNRPD2P1  
Affinity Capture-MS Homo sapiens
131 BARD1 580
Affinity Capture-MS Homo sapiens
132 DDX5 1655
Affinity Capture-MS Homo sapiens
133 NTRK1 4914
Affinity Capture-MS Homo sapiens
134 RPL31 6160
Proximity Label-MS Homo sapiens
135 LRPAP1 4043
Affinity Capture-MS Homo sapiens
136 HNRNPAB 3182
Affinity Capture-MS Homo sapiens
137 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
138 HNRNPA3P1  
Affinity Capture-MS Homo sapiens
139 LUC7L2 51631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 SNRPN 6638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 KPNB1 3837
Affinity Capture-MS Homo sapiens
142 ACTB 60
Affinity Capture-MS Homo sapiens
143 RFC4 5984
Affinity Capture-MS Homo sapiens
144 SNRNP27  
Affinity Capture-MS Homo sapiens
145 DHX9 1660
Affinity Capture-MS Homo sapiens
146 DDX17 10521
Affinity Capture-MS Homo sapiens
147 RPLP0 6175
Affinity Capture-MS Homo sapiens
148 KPNA5 3841
Affinity Capture-MS Homo sapiens
149 PRPF31 26121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 ACTG1 71
Affinity Capture-MS Homo sapiens
151 UBE2NL 389898
Affinity Capture-MS Homo sapiens
152 CCNT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 IPO9 55705
Affinity Capture-MS Homo sapiens
154 KDF1  
Affinity Capture-MS Homo sapiens
155 WDR82 80335
Affinity Capture-MS Homo sapiens
156 TRIP13 9319
Affinity Capture-MS Homo sapiens
157 HNRNPD 3184
Affinity Capture-MS Homo sapiens
158 UBE2S  
Affinity Capture-MS Homo sapiens
159 CKAP5 9793
Affinity Capture-MS Homo sapiens
160 FAM76B  
Affinity Capture-MS Homo sapiens
161 RPS19 6223
Affinity Capture-MS Homo sapiens
162 IPO5 3843
Affinity Capture-MS Homo sapiens
163 USP4 7375
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 BAX 581
Affinity Capture-MS Homo sapiens
165 SAP30BP  
Affinity Capture-MS Homo sapiens
166 CDC73  
Affinity Capture-MS Homo sapiens
167 SRSF7 6432
Affinity Capture-MS Homo sapiens
168 CLK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 PRPF4B 8899
Affinity Capture-MS Homo sapiens
170 POP1 10940
Affinity Capture-MS Homo sapiens
171 USP15 9958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 SRSF4 6429
Affinity Capture-MS Homo sapiens
173 JADE1  
Affinity Capture-MS Homo sapiens
174 CTTN 2017
Affinity Capture-MS Homo sapiens
175 MRPL9 65005
Affinity Capture-MS Homo sapiens
176 RQCD1 9125
Affinity Capture-MS Homo sapiens
177 CTSA 5476
Affinity Capture-MS Homo sapiens
178 CUL3 8452
Affinity Capture-MS Homo sapiens
179 METTL16 79066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 DCAF13 25879
Affinity Capture-MS Homo sapiens
181 SRSF5 6430
Affinity Capture-MS Homo sapiens
182 EXOSC5 56915
Affinity Capture-MS Homo sapiens
183 YY1 7528
Affinity Capture-MS Homo sapiens
184 ARF6 382
Affinity Capture-MS Homo sapiens
185 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 EIF4A1 1973
Affinity Capture-MS Homo sapiens
187 TSPYL5  
Affinity Capture-MS Homo sapiens
188 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
189 ANP32E 81611
Affinity Capture-MS Homo sapiens
190 KPNA2 3838
Affinity Capture-MS Homo sapiens
191 SART1 9092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 EFTUD2 9343
Affinity Capture-MS Homo sapiens
193 RPL29 6159
Affinity Capture-MS Homo sapiens
194 NSRP1  
Affinity Capture-MS Homo sapiens
195 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
196 RBM4B  
Affinity Capture-MS Homo sapiens
197 MFAP1  
Affinity Capture-MS Homo sapiens
198 PRPF19 27339
Co-fractionation Homo sapiens
199 PSPC1 55269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
200 RPA3 6119
Proximity Label-MS Homo sapiens
201 LSM3 27258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 ZFR 51663
Affinity Capture-MS Homo sapiens
203 YBX3 8531
Affinity Capture-MS Homo sapiens
204 SET 6418
Affinity Capture-MS Homo sapiens
205 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
206 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
207 TOP1 7150
Affinity Capture-MS Homo sapiens
208 NHP2L1 4809
Affinity Capture-MS Homo sapiens
209 EIF5A 1984
Affinity Capture-MS Homo sapiens
210 FIP1L1 81608
Affinity Capture-MS Homo sapiens
211 SART3 9733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 PRPF40A 55660
Affinity Capture-MS Homo sapiens
213 MATR3 9782
Affinity Capture-MS Homo sapiens
214 UPF3B 65109
Co-fractionation Homo sapiens
215 SNRPEP2  
Affinity Capture-MS Homo sapiens
216 BMI1  
Affinity Capture-MS Homo sapiens
217 G3BP1 10146
Affinity Capture-MS Homo sapiens
218 Rpl35 66489
Affinity Capture-MS Mus musculus
219 LRRC40 55631
Affinity Capture-MS Homo sapiens
220 ARHGAP23 57636
Affinity Capture-MS Homo sapiens
221 BRD3 8019
Affinity Capture-MS Homo sapiens
222 SF3B2 10992
Affinity Capture-MS Homo sapiens
223 YRDC 79693
Affinity Capture-MS Homo sapiens
224 PHGDH 26227
Affinity Capture-MS Homo sapiens
225 RPS16 6217
Affinity Capture-MS Homo sapiens
226 CBX4  
Affinity Capture-MS Homo sapiens
227 YBX1 4904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
228 NUDT21 11051
Affinity Capture-MS Homo sapiens
229 SFPQ 6421