Gene description for JUN
Gene name jun proto-oncogene
Gene symbol JUN
Other names/aliases AP-1
AP1
c-Jun
Species Homo sapiens
 Database cross references - JUN
ExoCarta ExoCarta_3725
Vesiclepedia VP_3725
Entrez Gene 3725
HGNC 6204
MIM 165160
UniProt P05412  
 JUN identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for JUN
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 TAS
    DNA-binding transcription factor activity GO:0003700 IDA
    RNA binding GO:0003723 HDA
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    cAMP response element binding GO:0035497 IDA
    identical protein binding GO:0042802 IPI
    ubiquitin-like protein ligase binding GO:0044389 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    R-SMAD binding GO:0070412 IPI
    general transcription initiation factor binding GO:0140296 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    regulation of transcription by RNA polymerase II GO:0006357 NAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    release from viral latency GO:0019046 IDA
    response to endoplasmic reticulum stress GO:0034976 IMP
    regulation of cell population proliferation GO:0042127 IBA
    positive regulation of apoptotic process GO:0043065 IMP
    negative regulation of DNA binding GO:0043392 IDA
    negative regulation by host of viral transcription GO:0043922 IDA
    positive regulation by host of viral transcription GO:0043923 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    response to steroid hormone GO:0048545 IBA
    regulation of cell cycle GO:0051726 IBA
    SMAD protein signal transduction GO:0060395 IDA
    integrated stress response signaling GO:0140467 NAS
    positive regulation of miRNA transcription GO:1902895 IMP
    positive regulation of miRNA transcription GO:1902895 ISS
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IMP
    positive regulation of DNA-templated transcription initiation GO:2000144 IDA
Subcellular Localization
    nuclear chromosome GO:0000228 TAS
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISA
    euchromatin GO:0000791 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IBA
    transcription factor AP-1 complex GO:0035976 IDA
    transcription factor AP-1 complex GO:0035976 IMP
    transcription factor AP-1 complex GO:0035976 IPI
    RNA polymerase II transcription regulator complex GO:0090575 IPI
 Experiment description of studies that identified JUN in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for JUN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 PRM2  
Affinity Capture-MS Homo sapiens
3 NCOA6  
Reconstituted Complex Homo sapiens
4 PPP3CA 5530
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 METTL17  
Affinity Capture-MS Homo sapiens
6 KMT2C 58508
Two-hybrid Homo sapiens
7 VARS 7407
Affinity Capture-MS Homo sapiens
8 CLEC3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CSK 1445
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 NFE2L1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 ATF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SKI 6497
Affinity Capture-Western Homo sapiens
13 NKRF 55922
Affinity Capture-MS Homo sapiens
14 BATF  
FRET Homo sapiens
15 PTX3 5806
Affinity Capture-MS Homo sapiens
16 SP1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 NACA 4666
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
18 GATA2  
Reconstituted Complex Homo sapiens
19 BRCA1 672
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 GTF2F1 2962
Reconstituted Complex Homo sapiens
21 TSG101 7251
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
22 JUND 3727
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
23 TRIM33 51592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CORO7 79585
Affinity Capture-MS Homo sapiens
25 OIP5  
Affinity Capture-MS Homo sapiens
26 UBC 7316
Two-hybrid Homo sapiens
PCA Homo sapiens
27 CSNK2A1 1457
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
28 KPNA2 3838
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
29 SUMO1 7341
PCA Homo sapiens
30 ARID3B  
Affinity Capture-MS Homo sapiens
31 TAF1  
Reconstituted Complex Homo sapiens
32 PRKDC 5591
Biochemical Activity Homo sapiens
33 CASP9 842
Biochemical Activity Homo sapiens
34 MAPK10 5602
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
35 SATB2  
Affinity Capture-MS Homo sapiens
36 HDAC1 3065
Affinity Capture-Western Homo sapiens
37 APEX1 328
Proximity Label-MS Homo sapiens
38 KAT7  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
39 PER2  
Affinity Capture-MS Homo sapiens
40 MRFAP1L1  
Affinity Capture-MS Homo sapiens
41 HDAC3 8841
Affinity Capture-Western Homo sapiens
42 NCOR1  
Co-localization Homo sapiens
43 SUV420H2  
Affinity Capture-MS Homo sapiens
44 DARS 1615
Affinity Capture-MS Homo sapiens
45 SPIB  
Reconstituted Complex Homo sapiens
46 HSP90AA1 3320
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
47 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SOGA1 140710
Affinity Capture-MS Homo sapiens
49 ATXN2L 11273
Affinity Capture-MS Homo sapiens
50 NR2F6  
Affinity Capture-MS Homo sapiens
51 MUC1 4582
Affinity Capture-Western Homo sapiens
52 PPP3CB  
FRET Homo sapiens
Reconstituted Complex Homo sapiens
53 COPS5 10987
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
54 MEF2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MEF2D  
Affinity Capture-MS Homo sapiens
56 AP1G1 164
Affinity Capture-Western Homo sapiens
57 COPS2 9318
Affinity Capture-Western Homo sapiens
58 STAT3 6774
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
59 ETV4  
Two-hybrid Homo sapiens
60 MAPK14 1432
Biochemical Activity Homo sapiens
61 ZBTB7C  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
62 DDX58 23586
Affinity Capture-RNA Homo sapiens
63 HMGA1 3159
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
64 KHSRP 8570
Affinity Capture-MS Homo sapiens
65 HAUS6  
Affinity Capture-MS Homo sapiens
66 TEAD1  
Proximity Label-MS Homo sapiens
67 APP 351
Reconstituted Complex Homo sapiens
68 RGS20 8601
Affinity Capture-MS Homo sapiens
69 CENPQ  
Affinity Capture-MS Homo sapiens
70 MLLT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 Smarcb1  
Affinity Capture-Western Mus musculus
72 INPP5B 3633
Affinity Capture-MS Homo sapiens
73 FBXW7  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
74 RPS6KA2  
Biochemical Activity Homo sapiens
75 FSD2 123722
Affinity Capture-MS Homo sapiens
76 CCNDBP1 23582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 VDR  
Reconstituted Complex Homo sapiens
78 ASF1A 25842
Co-localization Homo sapiens
79 SMARCB1 6598
Affinity Capture-MS Homo sapiens
80 STAT6 6778
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
81 NEDD4 4734
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
82 BATF2  
FRET Homo sapiens
FRET Homo sapiens
83 GSK3B 2932
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
84 HSPA8 3312
Reconstituted Complex Homo sapiens
85 EWSR1 2130
Reconstituted Complex Homo sapiens
86 NCOA1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
87 C15orf59  
Affinity Capture-MS Homo sapiens
88 MAPK1 5594
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
89 RB1 5925
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
90 GOPC 57120
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
91 MAPK8IP1 9479
Affinity Capture-Western Homo sapiens
92 POU1F1  
Reconstituted Complex Homo sapiens
93 VAV1 7409
Biochemical Activity Homo sapiens
94 MAPK3 5595
Biochemical Activity Homo sapiens
95 Smarca2  
Affinity Capture-Western Mus musculus
96 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
97 DDX21 9188
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
98 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
99 CDKN1A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
100 MEPCE 56257
Affinity Capture-MS Homo sapiens
101 NCOR2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
102 NBR1 4077
Affinity Capture-MS Homo sapiens
103 JDP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 MAPRE1 22919
Affinity Capture-MS Homo sapiens
105 NFIX 4784
Affinity Capture-MS Homo sapiens
106 ATF4  
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
107 ATF2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 UBXN7 26043
Affinity Capture-MS Homo sapiens
109 APLP2 334
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
110 CEBPE  
FRET Homo sapiens
111 UBE2I 7329
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
112 BBS7 55212
Reconstituted Complex Homo sapiens
113 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
114 TAF4 6874
Reconstituted Complex Homo sapiens
115 ARNTL  
Affinity Capture-MS Homo sapiens
116 LMO7 4008
Affinity Capture-Western Homo sapiens
117 PDS5A 23244
Affinity Capture-MS Homo sapiens
118 APOA2 336
Affinity Capture-MS Homo sapiens
119 AIM2  
Affinity Capture-MS Homo sapiens
120 DHX9 1660
Affinity Capture-MS Homo sapiens
121 PIAS2  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
122 ARNT 405
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 SIX4  
Affinity Capture-MS Homo sapiens
124 NFATC1 4772
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
125 RNF187  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
126 SMAD2 4087
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
127 BCL6  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
128 PML 5371
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
129 EBF3  
Affinity Capture-MS Homo sapiens
130 FBLN5 10516
Affinity Capture-MS Homo sapiens
131 SMARCE1 6605
Affinity Capture-MS Homo sapiens
132 GTF2F2 2963
Reconstituted Complex Homo sapiens
133 MBD3 53615
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
134 MAPK8 5599
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
135 ITCH 83737
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
136 ATF3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 CEBPA  
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
138 TMED1 11018
Affinity Capture-MS Homo sapiens
139 NFATC4 4776
Affinity Capture-MS Homo sapiens
140 SMARCC2 6601
Affinity Capture-MS Homo sapiens
141 MAP2K7 5609
Biochemical Activity Homo sapiens
142 NUCB2 4925
Affinity Capture-MS Homo sapiens
143 CBX4  
Affinity Capture-MS Homo sapiens
144 TRIP4 9325
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
145 FAM76B  
Affinity Capture-MS Homo sapiens
146 RBM39 9584
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
147 DCAF13 25879
Affinity Capture-MS Homo sapiens
148 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
149 MAZ 4150
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
150 NFAT5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
151 CLINT1 9685
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
152 NKX2-5  
Affinity Capture-MS Homo sapiens
153 AHCYL1 10768
Affinity Capture-MS Homo sapiens
154 DNMT3L  
Reconstituted Complex Homo sapiens
155 EPAS1  
FRET Homo sapiens
156 PPARG 5468
Protein-peptide Homo sapiens
157 SMAD3 4088
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
158 NFE2L2 4780
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
159 NFKBIA  
Affinity Capture-Western Homo sapiens
160 C14orf119  
Affinity Capture-MS Homo sapiens
161 MEX3A  
Affinity Capture-RNA Homo sapiens
162 HDAC9  
Reconstituted Complex Homo sapiens
163 Senp2  
Phenotypic Enhancement Mus musculus
164 PHLDB3  
Affinity Capture-MS Homo sapiens
165 NR3C1 2908
Reconstituted Complex Homo sapiens
166 DACH1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
167 PRKD1 5587
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
168 RPRD1A  
Affinity Capture-MS Homo sapiens
169 CEBPG  
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
170 MAP3K1 4214
Biochemical Activity Homo sapiens
171 BCL3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
172 NAT14 57106
Two-hybrid Homo sapiens
173 FOSL2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 FBXL12 54850
Affinity Capture-Western Homo sapiens
175 C21orf59 56683
Affinity Capture-MS Homo sapiens
176 CCDC85A  
Affinity Capture-MS Homo sapiens
177 MTA3 57504
Affinity Capture-Western Homo sapiens
178 TBP  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
179 JUN 3725
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
180 ARHGAP22 58504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 HOXD13  
Affinity Capture-MS Homo sapiens
182 STAT1 6772
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
183 PIAS1 8554
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
184 MYC  
Affinity Capture-Western Homo sapiens
185 ERG  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
186 TPM3P9  
Affinity Capture-MS Homo sapiens
187 EGFR 1956
Co-localization Homo sapiens
188 CHD3 1107
Affinity Capture-Western Homo sapiens
189 RUNX2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
190 PHF21A  
Affinity Capture-MS Homo sapiens
191 ETS1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
192 NFKB1 4790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
193 JUNB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
194 MAX  
Affinity Capture-MS Homo sapiens
195 M6PR 4074
Protein-peptide Homo sapiens
196 EDF1 8721
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
197 ITPK1 3705
Biochemical Activity Homo sapiens
198 FOSB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
199 NR5A1  
Reconstituted Complex Homo sapiens
200 NFYA 4800
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
201 NELFB 25920
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
202 TSC22D3  
Reconstituted Complex Homo sapiens
203 LIG3 3980
Affinity Capture-MS Homo sapiens
204 NFATC2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
205 GNB2L1 10399
Affinity Capture-Western Homo sapiens
206 MDM2  
Reconstituted Complex Homo sapiens
207 BATF3  
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 TPM3 7170
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 BACH2 60468
Affinity Capture-MS Homo sapiens
210 HIF1A 3091
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
211 STAT4  
Affinity Capture-Western Homo sapiens
212 CEBPB  
Affinity Capture-MS Homo sapiens
213 RELA 5970
Two-hybrid Homo sapiens
Phenotypic Enhancement Homo sapiens
214 BEND4  
Affinity Capture-MS Homo sapiens
215 PPP4C 5531
Reconstituted Complex Homo sapiens
216 PRRC2A 7916
Reconstituted Complex Homo sapiens
217 TRAF2 7186
Biochemical Activity Homo sapiens
218 PARP1 142
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
219 MYOD1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
220 HDGF 3068
Two-hybrid Homo sapiens
221 IARS 3376
Affinity Capture-MS Homo sapiens
222 MAP2K4 6416
Biochemical Activity Homo sapiens
223 MACF1 23499
Two-hybrid Homo sapiens
224 MTA1 9112
Reconstituted Complex Homo sapiens
225 RFWD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
226 FOSL1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
227 SSRP1 6749
Affinity Capture-MS Homo sapiens
228 PIN1 5300
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
229 SMARCC1 6599
Affinity Capture-MS Homo sapiens
230 KAT2B  
Affinity Capture-Western Homo sapiens
231 IFI16 3428
Affinity Capture-MS Homo sapiens
232 NUFIP2 57532
Affinity Capture-MS Homo sapiens
233 ETV1  
Reconstituted Complex Homo sapiens
234 HNRNPM 4670
Affinity Capture-MS Homo sapiens
235 ABL1 25
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
236 SMAD4  
Affinity Capture-MS Homo sapiens
237 CYTH1 9267
Affinity Capture-MS Homo sapiens
238 CREBBP  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
239 MAPRE3  
Reconstituted Complex Homo sapiens
240 FMNL3 91010
Affinity Capture-MS Homo sapiens
241 TAF2  
Affinity Capture-MS Homo sapiens
242 CCDC97  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
243 CREB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
244 SIRT1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
245 GTF2E2  
Reconstituted Complex Homo sapiens
246 GTF2B 2959
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
247 CCDC93 54520
Affinity Capture-MS Homo sapiens
248 RUNX1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
249 CREB5 9586
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
250 TOP2A 7153
Far Western Homo sapiens
251 ESR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
252 TGIF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
253 KLF5  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
254 MIF 4282
Affinity Capture-MS Homo sapiens
255 AHCYL2 23382
Affinity Capture-MS Homo sapiens
256 DDIT3 1649
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
257 STRN4 29888
Reconstituted Complex Homo sapiens
258 PHOX2A  
Reconstituted Complex Homo sapiens
259 ETS2  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
260 EEF1D 1936
Affinity Capture-MS Homo sapiens
261 ARRB1 408
Two-hybrid Homo sapiens
262 MAPK9 5601
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
263 RALBP1 10928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
264 TCF20  
Reconstituted Complex Homo sapiens
265 MYPOP  
Affinity Capture-MS Homo sapiens
266 BANP  
Affinity Capture-MS Homo sapiens
267 FOS 2353
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
268 NRIP1 8204
Reconstituted Complex Homo sapiens
269 Lmo7  
Affinity Capture-Western Mus musculus
270 HIRA  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
271 HOXB9  
Affinity Capture-MS Homo sapiens
272 CREB3  
Reconstituted Complex Homo sapiens
273 KDM2B 84678
Affinity Capture-Western Homo sapiens
274 AR 367
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
275 UBN1  
Co-localization Homo sapiens
276 CCDC67  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
277 PTRF 284119
Affinity Capture-MS Homo sapiens
278 SPI1  
Reconstituted Complex Homo sapiens
279 SATB1 6304
Affinity Capture-MS Homo sapiens
280 IKBKB 3551
Biochemical Activity Homo sapiens
281 RPA3 6119
Proximity Label-MS Homo sapiens
282 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
283 RANGAP1 5905
Affinity Capture-MS Homo sapiens
284 TFAP2A  
Affinity Capture-MS Homo sapiens
285 EP300 2033
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
286 ARIH1 25820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
287 HTR1A  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JUN is involved
PathwayEvidenceSource
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Activation of the AP-1 family of transcription factors TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Defective Intrinsic Pathway for Apoptosis IEA Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models IEA Reactome
Developmental Biology IEA Reactome
Disease IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death IEA Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interleukin-17 signaling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Killing mechanisms TAS Reactome
Leishmania infection TAS Reactome
MAP kinase activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases TAS Reactome
MAPK6/MAPK4 signaling TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Neurodegenerative Diseases IEA Reactome
Oxidative Stress Induced Senescence TAS Reactome
Parasitic Infection Pathways TAS Reactome
PIP3 activates AKT signaling IEA Reactome
PIP3 activates AKT signaling TAS Reactome
Pre-NOTCH Expression and Processing TAS Reactome
Pre-NOTCH Transcription and Translation TAS Reactome
PTEN Regulation IEA Reactome
PTEN Regulation TAS Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of PTEN gene transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by NOTCH TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
WNT5:FZD7-mediated leishmania damping TAS Reactome





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