Gene description for JUN
Gene name	jun proto-oncogene
Gene symbol	JUN
Other names/aliases	AP-1 AP1 c-Jun
Species	Homo sapiens
Database cross references - JUN
ExoCarta	ExoCarta_3725
Vesiclepedia	VP_3725
Entrez Gene	3725
HGNC	6204
MIM	165160
UniProt	P05412
JUN identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for JUN

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     DNA binding GO:0003677 TAS     DNA-binding transcription factor activity GO:0003700 IDA     RNA binding GO:0003723 HDA     GTPase activator activity GO:0005096 IDA     protein binding GO:0005515 IPI     enzyme binding GO:0019899 IPI     ubiquitin protein ligase binding GO:0031625 IPI     cAMP response element binding GO:0035497 IDA     identical protein binding GO:0042802 IPI     ubiquitin-like protein ligase binding GO:0044389 IPI     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     R-SMAD binding GO:0070412 IPI     general transcription initiation factor binding GO:0140296 IPI     sequence-specific double-stranded DNA binding GO:1990837 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     regulation of transcription by RNA polymerase II GO:0006357 IDA     regulation of transcription by RNA polymerase II GO:0006357 NAS     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     release from viral latency GO:0019046 IDA     response to endoplasmic reticulum stress GO:0034976 IMP     regulation of cell population proliferation GO:0042127 IBA     positive regulation of apoptotic process GO:0043065 IMP     negative regulation of DNA binding GO:0043392 IDA     negative regulation by host of viral transcription GO:0043922 IDA     positive regulation by host of viral transcription GO:0043923 IDA     negative regulation of DNA-templated transcription GO:0045892 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 NAS     response to steroid hormone GO:0048545 IBA     regulation of cell cycle GO:0051726 IBA     SMAD protein signal transduction GO:0060395 IDA     integrated stress response signaling GO:0140467 NAS     positive regulation of miRNA transcription GO:1902895 IMP     positive regulation of miRNA transcription GO:1902895 ISS     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IMP     positive regulation of DNA-templated transcription initiation GO:2000144 IDA Subcellular Localization     nuclear chromosome GO:0000228 TAS     chromatin GO:0000785 IDA     chromatin GO:0000785 ISA     euchromatin GO:0000791 IDA     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     transcription regulator complex GO:0005667 IBA     transcription factor AP-1 complex GO:0035976 IDA     transcription factor AP-1 complex GO:0035976 IMP     transcription factor AP-1 complex GO:0035976 IPI     RNA polymerase II transcription regulator complex GO:0090575 IPI