Gene description for JUN
Gene name	jun proto-oncogene
Gene symbol	JUN
Other names/aliases	AP-1 AP1 c-Jun
Species	Homo sapiens
Database cross references - JUN
ExoCarta	ExoCarta_3725
Entrez Gene	3725
HGNC	6204
MIM	165160
UniProt	P05412
JUN identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for JUN

Molecular Function     poly(A) RNA binding GO:0044822 IDA     RNA polymerase II activating transcription factor binding GO:0001102 IPI     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IBA     GTPase activator activity GO:0005096 IDA     protein binding GO:0005515 IPI     double-stranded DNA binding GO:0003690 IEA     RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA     cAMP response element binding GO:0035497 IDA     sequence-specific DNA binding transcription factor activity GO:0003700 IDA     transcription factor binding GO:0008134 IPI     DNA binding GO:0003677 TAS     RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IEA     transcription regulatory region DNA binding GO:0044212 IDA     RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription GO:0001190 IC     enzyme binding GO:0019899 IPI     R-SMAD binding GO:0070412 IPI     sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IC     HMG box domain binding GO:0071837 IEA     transcription coactivator activity GO:0003713 IDA Biological Process     learning GO:0007612 IEA     liver development GO:0001889 IEA     membrane depolarization GO:0051899 IEA     response to cAMP GO:0051591 IBA     positive regulation of DNA replication GO:0045740 IEA     positive regulation by host of viral transcription GO:0043923 IDA     toll-like receptor 4 signaling pathway GO:0034142 TAS     regulation of cell death GO:0010941 IBA     positive regulation of cell differentiation GO:0045597 IBA     regulation of cell proliferation GO:0042127 IBA     innate immune response GO:0045087 TAS     negative regulation of transcription, DNA-templated GO:0045892 IDA     negative regulation of neuron apoptotic process GO:0043524 IEA     negative regulation by host of viral transcription GO:0043922 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     toll-like receptor 2 signaling pathway GO:0034134 TAS     monocyte differentiation GO:0030224 IEA     negative regulation of protein autophosphorylation GO:0031953 IEA     positive regulation of DNA-templated transcription, initiation GO:2000144 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     cellular response to potassium ion starvation GO:0051365 IEA     SMAD protein import into nucleus GO:0007184 IDA     response to lipopolysaccharide GO:0032496 IBA     negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990441 IMP     negative regulation of DNA binding GO:0043392 IDA     positive regulation of fibroblast proliferation GO:0048146 IEA     negative regulation of cell proliferation GO:0008285 IEA     toll-like receptor 3 signaling pathway GO:0034138 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     outflow tract morphogenesis GO:0003151 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     positive regulation of neuron apoptotic process GO:0043525 IEA     positive regulation of transcription, DNA-templated GO:0045893 IDA     toll-like receptor 9 signaling pathway GO:0034162 TAS     regulation of cell cycle GO:0051726 IBA     circadian rhythm GO:0007623 IEA     SMAD protein signal transduction GO:0060395 IDA     stress-activated MAPK cascade GO:0051403 TAS     toll-like receptor signaling pathway GO:0002224 TAS     positive regulation of monocyte differentiation GO:0045657 IEA     response to radiation GO:0009314 IBA     release of cytochrome c from mitochondria GO:0001836 IEA     toll-like receptor 5 signaling pathway GO:0034146 TAS     cellular response to hormone stimulus GO:0032870 IBA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     response to cytokine GO:0034097 IBA     axon regeneration GO:0031103 IEA     response to drug GO:0042493 IBA     response to hydrogen peroxide GO:0042542 IEA     aging GO:0007568 IEA     transcription from RNA polymerase II promoter GO:0006366 IEA     positive regulation of endothelial cell proliferation GO:0001938 IEA     angiogenesis GO:0001525 IEA     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     positive regulation of GTPase activity GO:0043547 IDA     microglial cell activation GO:0001774 IEA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     leading edge cell differentiation GO:0035026 IEA     cellular response to calcium ion GO:0071277 IEA     response to mechanical stimulus GO:0009612 IBA Subcellular Localization     transcriptional repressor complex GO:0017053 IEA     nuclear chromosome GO:0000228 TAS     cytosol GO:0005829 IEA     transcription factor complex GO:0005667 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     nuclear euchromatin GO:0005719 IDA