Gene description for MAPK8IP1
Gene name mitogen-activated protein kinase 8 interacting protein 1
Gene symbol MAPK8IP1
Other names/aliases IB1
JIP-1
JIP1
PRKM8IP
Species Homo sapiens
 Database cross references - MAPK8IP1
ExoCarta ExoCarta_9479
Entrez Gene 9479
HGNC 6882
MIM 604641
UniProt Q9UQF2  
 MAPK8IP1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for MAPK8IP1
Molecular Function
    kinesin binding GO:0019894 IPI
    MAP-kinase scaffold activity GO:0005078 IPI
    protein binding GO:0005515 IPI
    JUN kinase binding GO:0008432 IEA
    protein kinase inhibitor activity GO:0004860 TAS
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IEA
    identical protein binding GO:0042802 IEA
    mitogen-activated protein kinase kinase binding GO:0031434 IEA
Biological Process
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    JUN phosphorylation GO:0007258 IEA
    negative regulation of JUN kinase activity GO:0043508 IEA
    positive regulation of signal transduction GO:0009967 IEA
    vesicle-mediated transport GO:0016192 ISS
    regulation of JNK cascade GO:0046328 ISS
Subcellular Localization
    mitochondrial membrane GO:0031966 IEA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IEA
    cell body GO:0044297 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    cytoplasm GO:0005737 IDA
    dentate gyrus mossy fiber GO:0044302 IEA
    dendritic growth cone GO:0044294 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    synapse GO:0045202 IEA
    axonal growth cone GO:0044295 IEA
 Experiment description of studies that identified MAPK8IP1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for MAPK8IP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 MAPK8IP3  
Invitro Homo sapiens
3 MAPK8IP1 9479
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 LRP1 4035
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
5 RECQL5  
Two-hybrid Homo sapiens
6 AKT1 207
Invivo Homo sapiens
7 TIAM1  
Affinity Capture-Western Homo sapiens
8 MAP3K13 9175
Invivo Homo sapiens
9 MAPK8 5599
Affinity Capture-Western Homo sapiens
10 MAP3K12  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 MAP3K10  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 MAPK9 5601
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
13 LRP8  
Two-hybrid Homo sapiens
14 MAPK8IP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
15 LRP2 4036
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 MAP3K11 4296
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 DUSP16  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which MAPK8IP1 is involved
No pathways found





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