Gene description for LRP8
Gene name low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene symbol LRP8
Other names/aliases APOER2
HSZ75190
LRP-8
MCI1
Species Homo sapiens
 Database cross references - LRP8
ExoCarta ExoCarta_7804
Vesiclepedia VP_7804
Entrez Gene 7804
HGNC 6700
MIM 602600
UniProt Q14114  
 LRP8 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRP8
Molecular Function
    amyloid-beta binding GO:0001540 IEA
    transmembrane signaling receptor activity GO:0004888 TAS
    low-density lipoprotein particle receptor activity GO:0005041 TAS
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    high-density lipoprotein particle binding GO:0008035 IEA
    kinesin binding GO:0019894 IEA
    very-low-density lipoprotein particle receptor activity GO:0030229 IDA
    apolipoprotein binding GO:0034185 IC
    cargo receptor activity GO:0038024 NAS
    reelin receptor activity GO:0038025 ISS
    calcium-dependent protein binding GO:0048306 IEA
Biological Process
    retinoid metabolic process GO:0001523 TAS
    proteolysis GO:0006508 NAS
    lipid metabolic process GO:0006629 NAS
    endocytosis GO:0006897 IDA
    signal transduction GO:0007165 TAS
    chemical synaptic transmission GO:0007268 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    cytokine-mediated signaling pathway GO:0019221 NAS
    ventral spinal cord development GO:0021517 IBA
    ammon gyrus development GO:0021541 ISS
    layer formation in cerebral cortex GO:0021819 IEA
    layer formation in cerebral cortex GO:0021819 ISS
    reelin-mediated signaling pathway GO:0038026 ISS
    regulation of apoptotic process GO:0042981 ISS
    regulation of innate immune response GO:0045088 ISS
    dendrite morphogenesis GO:0048813 IEA
    modulation of chemical synaptic transmission GO:0050804 ISS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    cellular response to growth factor stimulus GO:0071363 IEA
    cellular response to cholesterol GO:0071397 IEA
    positive regulation of dendrite development GO:1900006 ISS
Subcellular Localization
    extracellular space GO:0005615 IEA
    microtubule associated complex GO:0005875 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IBA
    caveola GO:0005901 IDA
    cell surface GO:0009986 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IC
    axon GO:0030424 IEA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    receptor complex GO:0043235 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified LRP8 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRP8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOS1AP  
Two-hybrid Homo sapiens
2 DENND6A 201627
Proximity Label-MS Homo sapiens
3 PRCC  
Affinity Capture-MS Homo sapiens
4 HNRNPD 3184
Affinity Capture-MS Homo sapiens
5 ANKFY1 51479
Proximity Label-MS Homo sapiens
6 GIPC1 10755
Two-hybrid Homo sapiens
7 MYLIP  
Protein-peptide Homo sapiens
8 DAB2 1601
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
9 USP11 8237
Affinity Capture-MS Homo sapiens
10 LAMTOR1 55004
Proximity Label-MS Homo sapiens
11 LAMP3  
Proximity Label-MS Homo sapiens
12 Pten  
Affinity Capture-MS Mus musculus
13 MAPK8IP2  
Two-hybrid Homo sapiens
14 SCN3A  
Two-hybrid Homo sapiens
15 RAB11A 8766
Proximity Label-MS Homo sapiens
16 ALB 213
Affinity Capture-MS Homo sapiens
17 ITGB1BP1 9270
Two-hybrid Homo sapiens
18 CUL3 8452
Affinity Capture-MS Homo sapiens
19 APOE 348
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
20 LAMP2 3920
Proximity Label-MS Homo sapiens
21 EGFR 1956
Affinity Capture-MS Homo sapiens
22 PRKRIP1 79706
Affinity Capture-MS Homo sapiens
23 ARF6 382
Proximity Label-MS Homo sapiens
24 DLG4  
Two-hybrid Homo sapiens
25 GHDC  
Affinity Capture-MS Homo sapiens
26 ANGEL2 90806
Affinity Capture-MS Homo sapiens
27 RAB2A 5862
Proximity Label-MS Homo sapiens
28 C19orf47  
Affinity Capture-MS Homo sapiens
29 NXF1 10482
Affinity Capture-RNA Homo sapiens
30 RAB4A 5867
Proximity Label-MS Homo sapiens
31 MAPK8IP1 9479
Two-hybrid Homo sapiens
32 RAB3B 5865
Proximity Label-MS Homo sapiens
33 RAB5A 5868
Proximity Label-MS Homo sapiens
34 PPP1R9A  
Affinity Capture-MS Homo sapiens
35 APOH 350
Affinity Capture-Western Homo sapiens
36 MKRN2 23609
Affinity Capture-RNA Homo sapiens
37 CRTC3  
Affinity Capture-MS Homo sapiens
38 CAMSAP3  
Affinity Capture-MS Homo sapiens
39 SNX17 9784
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
40 SYNJ2BP 55333
Two-hybrid Homo sapiens
41 ARHGAP39  
Affinity Capture-MS Homo sapiens
42 RAB7A 7879
Proximity Label-MS Homo sapiens
43 APBA2 321
Two-hybrid Homo sapiens
44 LRPAP1 4043
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
45 MOV10 4343
Affinity Capture-RNA Homo sapiens
46 EPHA2 1969
Proximity Label-MS Homo sapiens
47 RELN 5649
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
48 ANAPC10  
Two-hybrid Homo sapiens
49 KRAS 3845
Proximity Label-MS Homo sapiens
50 RAB5C 5878
Proximity Label-MS Homo sapiens
51 RHOB 388
Proximity Label-MS Homo sapiens
52 CAV1 857
Proximity Label-MS Homo sapiens
53 DOCK6 57572
Affinity Capture-MS Homo sapiens
54 RAD51  
Affinity Capture-MS Homo sapiens
55 DAB1 1600
Two-hybrid Homo sapiens
56 RAB9A 9367
Proximity Label-MS Homo sapiens
57 TYK2 7297
Affinity Capture-MS Homo sapiens
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