Gene description for LRP8
Gene name low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene symbol LRP8
Other names/aliases APOER2
HSZ75190
LRP-8
MCI1
Species Homo sapiens
 Database cross references - LRP8
ExoCarta ExoCarta_7804
Vesiclepedia VP_7804
Entrez Gene 7804
HGNC 6700
MIM 602600
UniProt Q14114  
 LRP8 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRP8
Molecular Function
    very-low-density lipoprotein particle receptor activity GO:0030229 IDA
    protein binding GO:0005515 IPI
    kinesin binding GO:0019894 IEA
    high-density lipoprotein particle binding GO:0008035 IEA
    reelin receptor activity GO:0038025 ISS
    calcium ion binding GO:0005509 IEA
    apolipoprotein binding GO:0034185 IC
    transmembrane signaling receptor activity GO:0004888 TAS
Biological Process
    blood coagulation GO:0007596 TAS
    layer formation in cerebral cortex GO:0021819 IEA
    cytokine-mediated signaling pathway GO:0019221 NAS
    reelin-mediated signaling pathway GO:0038026 ISS
    cellular response to growth factor stimulus GO:0071363 IEA
    ammon gyrus development GO:0021541 ISS
    signal transduction GO:0007165 TAS
    receptor-mediated endocytosis GO:0006898 IDA
    phototransduction, visible light GO:0007603 TAS
    regulation of synaptic transmission GO:0050804 ISS
    positive regulation of CREB transcription factor activity GO:0032793 ISS
    endocytosis GO:0006897 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    retinoid metabolic process GO:0001523 TAS
    response to drug GO:0042493 IEA
    cellular response to cholesterol GO:0071397 IEA
    proteolysis GO:0006508 NAS
    positive regulation of dendrite development GO:1900006 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    positive regulation of protein tyrosine kinase activity GO:0061098 ISS
    lipid metabolic process GO:0006629 NAS
Subcellular Localization
    integral component of membrane GO:0016021 IC
    postsynaptic density GO:0014069 IEA
    receptor complex GO:0043235 IDA
    axon GO:0030424 IEA
    membrane GO:0016020 IDA
    microtubule associated complex GO:0005875 IEA
    caveola GO:0005901 IDA
    extracellular region GO:0005576 IEA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified LRP8 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRP8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANAPC10  
Two-hybrid Homo sapiens
2 RELN 5649
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
3 MAPK8IP1 9479
Two-hybrid Homo sapiens
4 CAPON  
Two-hybrid Homo sapiens
5 ITGB1BP1 9270
Two-hybrid Homo sapiens
6 APOH 350
Affinity Capture-Western Homo sapiens
7 GIPC1 10755
Two-hybrid Homo sapiens
8 LRPAP1 4043
Reconstituted Complex Homo sapiens
9 SNX17 9784
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
10 SYNJ2BP 55333
Two-hybrid Homo sapiens
11 DLG4  
Two-hybrid Homo sapiens
12 DAB1 1600
Two-hybrid Homo sapiens
13 MAPK8IP2  
Two-hybrid Homo sapiens
14 APOE 348
Reconstituted Complex Homo sapiens
15 APBA2 321
Two-hybrid Homo sapiens
16 SCN3A  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LRP8 is involved
PathwayEvidenceSource
Platelet sensitization by LDL TAS Reactome
Retinoid metabolism and transport TAS Reactome





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