Gene description for DAB1
Gene name Dab, reelin signal transducer, homolog 1 (Drosophila)
Gene symbol DAB1
Other names/aliases -
Species Homo sapiens
 Database cross references - DAB1
ExoCarta ExoCarta_1600
Vesiclepedia VP_1600
Entrez Gene 1600
HGNC 2661
MIM 603448
UniProt O75553  
 DAB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DAB1
Molecular Function
    phosphatidylinositol 3-kinase binding GO:0043548 IEA
    protein binding GO:0005515 IPI
Biological Process
    dendrite development GO:0016358 IEA
    cerebellum structural organization GO:0021589 IEA
    radial glia guided migration of Purkinje cell GO:0021942 IEA
    negative regulation of cell adhesion GO:0007162 IEA
    negative regulation of astrocyte differentiation GO:0048712 IEA
    positive regulation of protein kinase activity GO:0045860 IEA
    lateral motor column neuron migration GO:0097477 IEA
    midgut development GO:0007494 IEA
    ventral spinal cord development GO:0021517 IEA
    adult walking behavior GO:0007628 IEA
    Golgi localization GO:0051645 IEA
    negative regulation of axonogenesis GO:0050771 IEA
    response to drug GO:0042493 IEA
    small GTPase mediated signal transduction GO:0007264 IEA
    negative regulation of JAK-STAT cascade GO:0046426 IEA
    cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration GO:0021813 IEA
    positive regulation of neuron differentiation GO:0045666 IEA
Subcellular Localization
    postsynaptic density GO:0014069 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    brush border GO:0005903 IEA
    neuronal cell body GO:0043025 IEA
    apical part of cell GO:0045177 IEA
    cytosol GO:0005829 IEA
    neuron projection GO:0043005 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified DAB1 in exosomes
1
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DAB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 APP 351
Reconstituted Complex Homo sapiens
3 LDLR 3949
Two-hybrid Homo sapiens
4 LRP1 4035
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
5 APLP2 334
Reconstituted Complex Homo sapiens
6 APLP1 333
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 VLDLR 7436
Two-hybrid Homo sapiens
8 MYO6 4646
Reconstituted Complex Homo sapiens
9 LRP2 4036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
10 PCDH18 54510
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
11 LRP8 7804
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DAB1 is involved
No pathways found





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