Gene description for PIN1
Gene name peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Gene symbol PIN1
Other names/aliases DOD
UBL5
Species Homo sapiens
 Database cross references - PIN1
ExoCarta ExoCarta_5300
Vesiclepedia VP_5300
Entrez Gene 5300
HGNC 8988
MIM 601052
UniProt Q13526  
 PIN1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for PIN1
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 EXP
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IDA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 NAS
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 TAS
    cytoskeletal motor activity GO:0003774 ISS
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    beta-catenin binding GO:0008013 ISS
    cis-trans isomerase activity GO:0016859 IMP
    mitogen-activated protein kinase kinase binding GO:0031434 IPI
    GTPase activating protein binding GO:0032794 IPI
    tau protein binding GO:0048156 NAS
    phosphoserine residue binding GO:0050815 IDA
    phosphothreonine residue binding GO:0050816 IDA
    phosphothreonine residue binding GO:0050816 IPI
    phosphoprotein binding GO:0051219 ISS
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
    ubiquitin ligase activator activity GO:1990757 IDA
Biological Process
    protein peptidyl-prolyl isomerization GO:0000413 IDA
    protein peptidyl-prolyl isomerization GO:0000413 TAS
    response to hypoxia GO:0001666 IDA
    regulation of protein phosphorylation GO:0001932 IDA
    positive regulation of protein phosphorylation GO:0001934 IGI
    protein targeting to mitochondrion GO:0006626 IMP
    regulation of mitotic nuclear division GO:0007088 TAS
    regulation of gene expression GO:0010468 IDA
    neuron differentiation GO:0030182 ISS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA
    regulation of protein stability GO:0031647 IMP
    negative regulation of protein binding GO:0032091 IDA
    positive regulation of protein binding GO:0032092 IDA
    regulation of cytokinesis GO:0032465 IGI
    regulation of cytokinesis GO:0032465 IMP
    negative regulation of protein catabolic process GO:0042177 IDA
    positive regulation of GTPase activity GO:0043547 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    microtubule polymerization GO:0046785 IDA
    synapse organization GO:0050808 ISS
    protein stabilization GO:0050821 IDA
    protein stabilization GO:0050821 ISS
    negative regulation of SMAD protein signal transduction GO:0060392 IDA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    cellular response to hypoxia GO:0071456 IMP
    positive regulation of canonical Wnt signaling pathway GO:0090263 IDA
    regulation of protein localization to nucleus GO:1900180 IDA
    negative regulation of amyloid-beta formation GO:1902430 IMP
    negative regulation of amyloid-beta formation GO:1902430 ISS
    negative regulation of cell motility GO:2000146 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    nuclear speck GO:0016607 IEA
    midbody GO:0030496 IDA
    ciliary basal body GO:0036064 IDA
    glutamatergic synapse GO:0098978 IDA
    postsynaptic cytosol GO:0099524 IDA
 Experiment description of studies that identified PIN1 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
15
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
16
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBS 875
Two-hybrid Homo sapiens
2 SSBP4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 CENPB 1059
Two-hybrid Homo sapiens
4 AJUBA  
Two-hybrid Homo sapiens
5 ATP6V1B2 526
Co-fractionation Homo sapiens
6 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
Reconstituted Complex Homo sapiens
7 HNRNPC 3183
Two-hybrid Homo sapiens
8 TNIP1 10318
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 CCDC88B 283234
Two-hybrid Homo sapiens
10 SNX3 8724
Co-fractionation Homo sapiens
11 CNKSR1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 UBE2A  
Co-fractionation Homo sapiens
13 QARS 5859
Two-hybrid Homo sapiens
14 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 AATF  
Affinity Capture-Western Homo sapiens
16 RPRD1B 58490
Affinity Capture-MS Homo sapiens
17 ZBTB22  
Two-hybrid Homo sapiens
18 TSC2 7249
Two-hybrid Homo sapiens
19 PKM 5315
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
20 ANKRD40 91369
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 DAZAP1 26528
Co-fractionation Homo sapiens
22 SPERT  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 NUP62 23636
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 NEUROD4  
Two-hybrid Homo sapiens
25 TCF12  
Two-hybrid Homo sapiens
26 AP2A1 160
Reconstituted Complex Homo sapiens
27 BRCA1 672
Reconstituted Complex Homo sapiens
28 APLP1 333
Two-hybrid Homo sapiens
29 COL11A2 1302
Two-hybrid Homo sapiens
30 MYF5  
Two-hybrid Homo sapiens
31 MDFI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 DAB1 1600
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 KRT37 8688
Two-hybrid Homo sapiens
34 TOX3  
Two-hybrid Homo sapiens
35 CSNK2A1 1457
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
36 PPIA 5478
Co-fractionation Homo sapiens
37 VHL  
Affinity Capture-MS Homo sapiens
38 SCAI  
Two-hybrid Homo sapiens
39 NELFA  
Two-hybrid Homo sapiens
40 CFL1 1072
Co-fractionation Homo sapiens
41 ATN1  
Two-hybrid Homo sapiens
42 STK3 6788
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
43 FOXO4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
44 SCYL1 57410
Two-hybrid Homo sapiens
45 KIF5A 3798
Two-hybrid Homo sapiens
46 CCDC90B  
Two-hybrid Homo sapiens
47 SFPQ 6421
Reconstituted Complex Homo sapiens
48 CAPRIN1 4076
Reconstituted Complex Homo sapiens
49 MYT1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
50 PCBP2 5094
Co-fractionation Homo sapiens
51 CPNE6 9362
Two-hybrid Homo sapiens
52 DNAAF2  
Affinity Capture-MS Homo sapiens
53 TOP2A 7153
Affinity Capture-Western Homo sapiens
54 MED1 5469
Reconstituted Complex Homo sapiens
55 HDAC3 8841
Affinity Capture-Western Homo sapiens
56 TSC22D4 81628
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
57 KRTAP10-6  
Two-hybrid Homo sapiens
58 GTF2E2  
Affinity Capture-MS Homo sapiens
59 G3BP2 9908
Reconstituted Complex Homo sapiens
60 DDX24 57062
Two-hybrid Homo sapiens
61 DDB1 1642
Reconstituted Complex Homo sapiens
62 NDUFA7 4701
Co-fractionation Homo sapiens
63 MAP1S 55201
Reconstituted Complex Homo sapiens
64 FBXW7  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
65 FKBP1A 2280
Co-fractionation Homo sapiens
66 MOCS1  
Two-hybrid Homo sapiens
67 ETV6  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
68 SRRM2 23524
Reconstituted Complex Homo sapiens
69 KCTD7 154881
Two-hybrid Homo sapiens
70 KRTAP4-2  
Two-hybrid Homo sapiens
71 NCOA3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
72 MTUS2 23281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
73 CCDC6 8030
Two-hybrid Homo sapiens
74 KRT31 3881
Two-hybrid Homo sapiens
75 ADARB1 104
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
76 SUPT6H 6830
Affinity Capture-MS Homo sapiens
77 INO80E  
Two-hybrid Homo sapiens
78 ITGA4 3676
Affinity Capture-MS Homo sapiens
79 TAGLN3 29114
Co-fractionation Homo sapiens
80 KRT34  
Two-hybrid Homo sapiens
81 ATG16L1 55054
Affinity Capture-MS Homo sapiens
82 ZNF526  
Two-hybrid Homo sapiens
83 TBCA 6902
Co-fractionation Homo sapiens
84 ARID5A  
Two-hybrid Homo sapiens
85 KLHL20  
Two-hybrid Homo sapiens
86 WIZ 58525
Two-hybrid Homo sapiens
87 NR4A3  
Two-hybrid Homo sapiens
88 VPS16 64601
Affinity Capture-MS Homo sapiens
89 SOCS3 9021
Two-hybrid Homo sapiens
90 FOXP2 93986
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
91 ERBB2 2064
Affinity Capture-Western Homo sapiens
92 ARHGEF15  
Two-hybrid Homo sapiens
93 SOD1 6647
Co-fractionation Homo sapiens
94 SELV  
Two-hybrid Homo sapiens
95 TFG 10342
Reconstituted Complex Homo sapiens
96 LRIF1  
Two-hybrid Homo sapiens
97 ZNF446  
Two-hybrid Homo sapiens
98 TRIM59  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
99 TBC1D4  
Reconstituted Complex Homo sapiens
100 RAB4A 5867
Affinity Capture-Western Homo sapiens
101 GOLGA6L9  
Two-hybrid Homo sapiens
102 RB1 5925
Negative Genetic Homo sapiens
103 E2F4  
Two-hybrid Homo sapiens
104 FOSL1  
Two-hybrid Homo sapiens
105 RELA 5970
Affinity Capture-Western Homo sapiens
106 PBX1 5087
Two-hybrid Homo sapiens
107 FHL5 9457
Two-hybrid Homo sapiens
108 KRTAP5-9  
Two-hybrid Homo sapiens
109 PRPF8 10594
Reconstituted Complex Homo sapiens
110 CEP55 55165
Two-hybrid Homo sapiens
111 LEPR 3953
Two-hybrid Homo sapiens
112 NCKIPSD 51517
Two-hybrid Homo sapiens
113 RPL4 6124
Reconstituted Complex Homo sapiens
114 TAB3 257397
Two-hybrid Homo sapiens
115 SUPT5H 6829
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
116 CCDC33 80125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
117 KRTAP10-1  
Two-hybrid Homo sapiens
118 NONO 4841
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
119 BAG6 7917
Two-hybrid Homo sapiens
120 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
121 SNRNP200 23020
Reconstituted Complex Homo sapiens
122 UBQLN2 29978
Two-hybrid Homo sapiens
123 MAPT  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
124 PABPC1 26986
Reconstituted Complex Homo sapiens
125 GPR152  
Two-hybrid Homo sapiens
126 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 BARD1 580
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
128 DDX5 1655
Reconstituted Complex Homo sapiens
129 CASP6 839
Two-hybrid Homo sapiens
130 SPR 6697
Co-fractionation Homo sapiens
131 SMAD3 4088
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
132 U2AF2 11338
Reconstituted Complex Homo sapiens
133 PLK1 5347
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
134 PPP2CA 5515
Co-fractionation Homo sapiens
135 MEOX2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
136 BICD2 23299
Proximity Label-MS Homo sapiens
137 PRRC1 133619
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
138 UNC119 9094
Two-hybrid Homo sapiens
139 BCL2  
Affinity Capture-Western Homo sapiens
140 PML 5371
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
141 SNRNP27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 DDX17 10521
Reconstituted Complex Homo sapiens
143 HOMEZ  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
144 CDC27 996
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
145 TRMT2A 27037
Two-hybrid Homo sapiens
146 EFTUD2 9343
Reconstituted Complex Homo sapiens
147 YAP1 10413
Co-fractionation Homo sapiens
148 REST 5978
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
149 CEBPA  
Protein-peptide Homo sapiens
150 KIF20B  
Phenotypic Suppression Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
151 ATP5B 506
Two-hybrid Homo sapiens
152 DAXX  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
153 RAI1 10743
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
154 KRTAP10-7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
155 DDAH2 23564
Two-hybrid Homo sapiens
156 SSBP3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
157 FOXI1  
Two-hybrid Homo sapiens
158 BCLAF1 9774
Reconstituted Complex Homo sapiens
159 BCL11A 53335
Two-hybrid Homo sapiens
160 SRSF11 9295
Reconstituted Complex Homo sapiens
161 CBFA2T3  
Two-hybrid Homo sapiens
162 EIF3G 8666
Two-hybrid Homo sapiens
163 PKMYT1  
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
164 PTOV1  
Two-hybrid Homo sapiens
165 ZBTB2 57621
Two-hybrid Homo sapiens
166 DYNC1I1  
Two-hybrid Homo sapiens
167 C2orf49 79074
Affinity Capture-MS Homo sapiens
168 NUP43 348995
Proximity Label-MS Homo sapiens
169 GPAA1 8733
Two-hybrid Homo sapiens
170 HADHA 3030
Reconstituted Complex Homo sapiens
171 UBE2H 7328
Affinity Capture-MS Homo sapiens
172 GSK3A 2931
Affinity Capture-Western Homo sapiens
173 DHX15 1665
Reconstituted Complex Homo sapiens
174 CPEB1  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
175 WRNIP1 56897
Reconstituted Complex Homo sapiens
176 CLPP 8192
Proximity Label-MS Homo sapiens
177 IKZF3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
178 PPARG 5468
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
179 KRTAP10-8  
Two-hybrid Homo sapiens
180 CTNNB1 1499
Reconstituted Complex Homo sapiens
181 NFKBIA  
Affinity Capture-Western Homo sapiens
182 EFS  
Two-hybrid Homo sapiens
183 BRD8 10902
Two-hybrid Homo sapiens
184 TJP1 7082
Co-fractionation Homo sapiens
185 CCNE1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
186 SNCAIP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
187 CYP1A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 OSGEP 55644
Affinity Capture-MS Homo sapiens
189 GLI1  
Two-hybrid Homo sapiens
190 TFPT  
Two-hybrid Homo sapiens
191 KRTAP10-3  
Two-hybrid Homo sapiens
192 HOXA1 3198
Two-hybrid Homo sapiens
193 IKZF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
194 POLR2A 5430
Affinity Capture-Western Homo sapiens
195 RBBP8NL  
Two-hybrid Homo sapiens
196 WEE1 7465
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
197 RUNX3  
Affinity Capture-Western Homo sapiens
198 DUSP6 1848
Affinity Capture-MS Homo sapiens
199 POLR2D  
Affinity Capture-MS Homo sapiens
200 JUN 3725
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
201 CDC25C  
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
202 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 ZMIZ2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
204 CSAD 51380
Two-hybrid Homo sapiens
205 FOS 2353
Two-hybrid Homo sapiens
206 MYC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
207 SMAD2 4087
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
208 SIK1  
Affinity Capture-Western Homo sapiens
209 CCDC153  
Two-hybrid Homo sapiens
210 MSI2 124540
Co-fractionation Homo sapiens
211 CSNK2A2 1459
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
212 RUNX2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
213 RPL35A 6165
Affinity Capture-MS Homo sapiens
214 GGA2 23062
Two-hybrid Homo sapiens
215 TNS2 23371
Two-hybrid Homo sapiens
216 UBQLN4 56893
Two-hybrid Homo sapiens
217 ZBTB7B  
Two-hybrid Homo sapiens
218 BICD1 636
Proximity Label-MS Homo sapiens
219 AMOT 154796
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
220 DAB2 1601
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
221 ZBTB14  
Two-hybrid Homo sapiens
222 CARHSP1 23589
Two-hybrid Homo sapiens
223 G3BP1 10146
Reconstituted Complex Homo sapiens
224 BCL6  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
225 NUP35 129401
Two-hybrid Homo sapiens
226 FKBP1B  
Co-fractionation Homo sapiens
227 CDKN1B 1027
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
228 CDK10  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
229 HINT1 3094
Co-fractionation Homo sapiens
230 NFATC2  
Reconstituted Complex Homo sapiens
231 TP73  
Affinity Capture-Western Homo sapiens
232 APBA1  
Affinity Capture-MS Homo sapiens
233 IRF3 3661
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
234 CCDC184  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
235 RBBP8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
236 HIF1A 3091
Affinity Capture-Western Homo sapiens
237 MLLT6  
Two-hybrid Homo sapiens
238 SHKBP1  
Two-hybrid Homo sapiens
239 HSPE1 3336
Co-fractionation Homo sapiens
240 TRIP6 7205
Two-hybrid Homo sapiens
241 SNCA 6622
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
242 PDLIM7 9260
Two-hybrid Homo sapiens
243 GOT2 2806
Co-fractionation Homo sapiens
244 RARA 5914
Reconstituted Complex Homo sapiens
245 TRAF2 7186
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
246 SGK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
247 KRT40  
Two-hybrid Homo sapiens
248 PNMA1 9240
Two-hybrid Homo sapiens
249 NME1-NME2 654364
Co-fractionation Homo sapiens
250 SRRM1 10250
Reconstituted Complex Homo sapiens
251 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
252 SYAP1 94056
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
253 CEP76  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
254 GMEB2  
Two-hybrid Homo sapiens
255 DEAF1 10522
Two-hybrid Homo sapiens
256 KMT2B  
Two-hybrid Homo sapiens
257 CDK11B 984
Reconstituted Complex Homo sapiens
258 PKIB  
Two-hybrid Homo sapiens
259 PLAGL2  
Two-hybrid Homo sapiens
260 C3orf36  
Two-hybrid Homo sapiens
261 MCL1 4170
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
262 TRIM27  
Two-hybrid Homo sapiens
263 CHAMP1  
Reconstituted Complex Homo sapiens
264 KEAP1 9817
Negative Genetic Homo sapiens
265 CCNK  
Reconstituted Complex Homo sapiens
266 GPX4 2879
Co-fractionation Homo sapiens
267 PIM1  
Affinity Capture-Western Homo sapiens
268 THRAP3 9967
Reconstituted Complex Homo sapiens
269 SSBP2  
Two-hybrid Homo sapiens
270 TLE3  
Reconstituted Complex Homo sapiens
271 HDAC1 3065
Co-fractionation Homo sapiens
272 CDK2 1017
Reconstituted Complex Homo sapiens
273 CDK12 51755
Reconstituted Complex Homo sapiens
274 OTUB1 55611
Affinity Capture-MS Homo sapiens
275 FOXN1  
Two-hybrid Homo sapiens
276 AXIN1  
Affinity Capture-Western Homo sapiens
277 TUT1  
Reconstituted Complex Homo sapiens
278 HNRNPK 3190
Reconstituted Complex Homo sapiens
279 ZNF684  
Affinity Capture-MS Homo sapiens
280 THAP7  
Two-hybrid Homo sapiens
281 ADAMTSL4  
Two-hybrid Homo sapiens
282 UBXN2B  
Two-hybrid Homo sapiens
283 KIAA1429 25962
Reconstituted Complex Homo sapiens
284 STIL  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
285 ABI2 10152
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
286 DDX3X 1654
Reconstituted Complex Homo sapiens
287 TCF4  
Two-hybrid Homo sapiens
288 HEXIM2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
289 KIFC3 3801
Two-hybrid Homo sapiens
290 TAGLN2 8407
Co-fractionation Homo sapiens
291 KRT38 8687
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
292 DMPK  
Two-hybrid Homo sapiens
293 JAKMIP2  
Two-hybrid Homo sapiens
294 NAB2 4665
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
295 ZBTB9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
296 FRS2 10818
Two-hybrid Homo sapiens
297 ZNF768 79724
Two-hybrid Homo sapiens
298 ZCCHC10  
Two-hybrid Homo sapiens
299 RNPS1 10921
Reconstituted Complex Homo sapiens
300 MAP3K11 4296
Two-hybrid Homo sapiens
301 REPS1 85021
Reconstituted Complex Homo sapiens
302 DIDO1  
Affinity Capture-MS Homo sapiens
303 GRSF1 2926
Two-hybrid Homo sapiens
304 XRCC6 2547
Reconstituted Complex Homo sapiens
305 SNX12 29934
Co-fractionation Homo sapiens
306 CUL7 9820
Affinity Capture-MS Homo sapiens
307 ZNF783  
Two-hybrid Homo sapiens
308 HNRNPU 3192
Reconstituted Complex Homo sapiens
309 LCN2 3934
Two-hybrid Homo sapiens
310 FABP5 2171
Co-fractionation Homo sapiens
311 ZBTB42  
Two-hybrid Homo sapiens
312 GABPA 2551
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
313 ZNF449  
Two-hybrid Homo sapiens
314 SSC5D 284297
Two-hybrid Homo sapiens
315 CDK11A 728642
Reconstituted Complex Homo sapiens
316 ATCAY  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
317 RNF208  
Two-hybrid Homo sapiens
318 EP300 2033
Reconstituted Complex Homo sapiens
319 TRAF1 7185
Two-hybrid Homo sapiens
320 KRTAP10-9  
Two-hybrid Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here