Gene description for TSC22D4
Gene name TSC22 domain family, member 4
Gene symbol TSC22D4
Other names/aliases THG-1
THG1
TILZ2
Species Homo sapiens
 Database cross references - TSC22D4
ExoCarta ExoCarta_81628
Vesiclepedia VP_81628
Entrez Gene 81628
HGNC 21696
MIM 611914
UniProt Q9Y3Q8  
 TSC22D4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TSC22D4
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 NAS
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified TSC22D4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TSC22D4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SAT  
Two-hybrid Homo sapiens
2 MAD2L1 4085
Two-hybrid Homo sapiens
3 NIF3L1 60491
Two-hybrid Homo sapiens
4 PIN1 5300
Two-hybrid Homo sapiens
5 GORASP2 26003
Two-hybrid Homo sapiens
6 TEX11  
Two-hybrid Homo sapiens
7 MTHFS 10588
Two-hybrid Homo sapiens
8 ZMYND10 51364
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 CDC23 8697
Two-hybrid Homo sapiens
10 FLJ32734  
Two-hybrid Homo sapiens
11 CCDC33 80125
Two-hybrid Homo sapiens
12 PSMA1 5682
Two-hybrid Homo sapiens
13 FLJ20643  
Two-hybrid Homo sapiens
14 SYT17  
Two-hybrid Homo sapiens
15 CCNK  
Two-hybrid Homo sapiens
16 NRBP1 29959
Two-hybrid Homo sapiens
17 C16orf48  
Two-hybrid Homo sapiens
18 FXR2 9513
Two-hybrid Homo sapiens
19 ABLIM1 3983
Two-hybrid Homo sapiens
20 LNX  
Two-hybrid Homo sapiens
21 NOC4L 79050
Two-hybrid Homo sapiens
22 ZNF580  
Two-hybrid Homo sapiens
23 CDK5R1  
Two-hybrid Homo sapiens
24 GNB2L1 10399
Two-hybrid Homo sapiens
25 CKS2  
Two-hybrid Homo sapiens
26 MGC10067  
Two-hybrid Homo sapiens
27 FRMD6 122786
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TSC22D4 is involved
No pathways found





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