Gene description for PRKD2
Gene name protein kinase D2
Gene symbol PRKD2
Other names/aliases HSPC187
PKD2
nPKC-D2
Species Homo sapiens
 Database cross references - PRKD2
ExoCarta ExoCarta_25865
Entrez Gene 25865
HGNC 17293
MIM 607074
UniProt Q9BZL6  
 PRKD2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PRKD2
Molecular Function
    ATP binding GO:0005524 IEA
    protein kinase activity GO:0004672 IDA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    protein kinase C activity GO:0004697 IEA
    protein serine/threonine kinase activity GO:0004674 NAS
Biological Process
    cell death GO:0008219 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    peptidyl-serine phosphorylation GO:0018105 IDA
    positive regulation of endothelial cell chemotaxis GO:2001028 IMP
    protein kinase D signaling GO:0089700 IGI
    intracellular signal transduction GO:0035556 IMP
    positive regulation of interleukin-8 production GO:0032757 IMP
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IMP
    positive regulation of intracellular signal transduction GO:1902533 IMP
    positive regulation of angiogenesis GO:0045766 IMP
    endothelial tube morphogenesis GO:0061154 TAS
    positive regulation of T cell receptor signaling pathway GO:0050862 ISS
    angiogenesis GO:0001525 IEA
    positive regulation of endothelial cell migration GO:0010595 IMP
    positive regulation of DNA biosynthetic process GO:2000573 ISS
    positive regulation of interleukin-2 production GO:0032743 ISS
    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 IMP
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    T cell receptor signaling pathway GO:0050852 IDA
    positive regulation of cell adhesion GO:0045785 IMP
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    cell adhesion GO:0007155 IEA
    positive regulation of CREB transcription factor activity GO:0032793 IGI
    positive regulation of histone deacetylase activity GO:1901727 IGI
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IMP
    positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 IMP
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IGI
    protein phosphorylation GO:0006468 NAS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 IMP
    positive regulation of endothelial cell proliferation GO:0001938 IMP
    positive regulation of blood vessel endothelial cell migration GO:0043536 IMP
    protein autophosphorylation GO:0046777 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    plasma membrane GO:0005886 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PRKD2 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRKD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRKD2 is involved
No pathways found





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