Gene description for VIPAS39
Gene name VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Gene symbol VIPAS39
Other names/aliases C14orf133
SPE-39
SPE39
VIPAR
VPS16B
hSPE-39
Species Homo sapiens
 Database cross references - VIPAS39
ExoCarta ExoCarta_63894
Vesiclepedia VP_63894
Entrez Gene 63894
HGNC 20347
MIM 613401
UniProt Q9H9C1  
 VIPAS39 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for VIPAS39
Molecular Function
    protein binding GO:0005515 IPI
    protein-containing complex binding GO:0044877 IDA
Biological Process
    intracellular protein transport GO:0006886 IBA
    intracellular protein transport GO:0006886 IMP
    vacuolar transport GO:0007034 IBA
    spermatogenesis GO:0007283 IEA
    endosome to lysosome transport GO:0008333 IMP
    endosome to lysosome transport GO:0008333 IMP
    peptidyl-lysine hydroxylation GO:0017185 IMP
    cell differentiation GO:0030154 IEA
    collagen fibril organization GO:0030199 IEA
    collagen metabolic process GO:0032963 IMP
    post-translational protein modification GO:0043687 IEA
    intracellular transport GO:0046907 NAS
    phagosome-lysosome fusion GO:0090385 NAS
    autophagosome maturation GO:0097352 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endosome GO:0005768 IDA
    early endosome GO:0005769 IDA
    late endosome GO:0005770 IDA
    Golgi apparatus GO:0005794 IDA
    HOPS complex GO:0030897 IDA
    recycling endosome GO:0055037 IDA
    vesicle tethering complex GO:0099023 IPI
 Experiment description of studies that identified VIPAS39 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VIPAS39
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COLGALT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CHMP3 51652
Affinity Capture-MS Homo sapiens
3 VPS41 27072
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 LYG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PRKD2 25865
Affinity Capture-MS Homo sapiens
7 CUL3 8452
Affinity Capture-MS Homo sapiens
8 LAMTOR1 55004
Proximity Label-MS Homo sapiens
9 ATG9A 79065
Proximity Label-MS Homo sapiens
10 PIP 5304
Affinity Capture-MS Homo sapiens
11 YWHAB 7529
Affinity Capture-MS Homo sapiens
12 WASF2 10163
Affinity Capture-MS Homo sapiens
13 MATN4 8785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LAMP1 3916
Proximity Label-MS Homo sapiens
15 RABIF  
Affinity Capture-MS Homo sapiens
16 Vps39  
Affinity Capture-Western Mus musculus
17 Vps11  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
18 KIF1B 23095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 Vps18  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
20 VPS33A 65082
Affinity Capture-Western Homo sapiens
21 RAB4A 5867
Proximity Label-MS Homo sapiens
22 Vps16  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
23 PLOD3 8985
Affinity Capture-MS Homo sapiens
24 FIS1 51024
Proximity Label-MS Homo sapiens
25 MTMR7  
Affinity Capture-MS Homo sapiens
26 OGT 8473
Reconstituted Complex Homo sapiens
27 RAB7A 7879
Proximity Label-MS Homo sapiens
28 RAB11A 8766
Proximity Label-MS Homo sapiens
29 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 VPS39 23339
Co-fractionation Homo sapiens
31 VPS33B 26276
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
32 RHOT2 89941
Proximity Label-MS Homo sapiens
33 STX6 10228
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which VIPAS39 is involved
No pathways found





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