Gene description for PIP
Gene name prolactin-induced protein
Gene symbol PIP
Other names/aliases GCDFP-15
GCDFP15
GPIP4
Species Homo sapiens
 Database cross references - PIP
ExoCarta ExoCarta_5304
Vesiclepedia VP_5304
Entrez Gene 5304
HGNC 8993
MIM 176720
UniProt P12273  
 PIP identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells Unpublished / Not applicable
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for PIP
Molecular Function
    actin binding GO:0003779 NAS
    aspartic-type endopeptidase activity GO:0004190 IBA
    aspartic-type endopeptidase activity GO:0004190 IMP
    protein binding GO:0005515 IPI
    IgG binding GO:0019864 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 IDA
    regulation of immune system process GO:0002682 IBA
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IMP
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of T cell apoptotic process GO:0070233 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PIP in exosomes
1
Experiment ID 494
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
7
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
8
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRTC2 200186
Affinity Capture-MS Homo sapiens
2 SECISBP2  
Affinity Capture-MS Homo sapiens
3 DGCR14  
Affinity Capture-MS Homo sapiens
4 LYZ 4069
Affinity Capture-MS Homo sapiens
5 TOR1A 1861
Affinity Capture-MS Homo sapiens
6 RBPMS 11030
Affinity Capture-MS Homo sapiens
7 ARHGAP39  
Affinity Capture-MS Homo sapiens
8 USPL1  
Affinity Capture-MS Homo sapiens
9 YTHDF1 54915
Affinity Capture-MS Homo sapiens
10 CD4 920
Reconstituted Complex Homo sapiens
11 STRN3 29966
Affinity Capture-MS Homo sapiens
12 TDRD3  
Affinity Capture-MS Homo sapiens
13 N4BP2L2 10443
Affinity Capture-MS Homo sapiens
14 CBY1  
Affinity Capture-MS Homo sapiens
15 EIF4E2  
Affinity Capture-MS Homo sapiens
16 FNDC5  
Affinity Capture-MS Homo sapiens
17 POLH  
Affinity Capture-MS Homo sapiens
18 HOXB9  
Affinity Capture-MS Homo sapiens
19 MASTL  
Affinity Capture-MS Homo sapiens
20 ZBTB33  
Affinity Capture-MS Homo sapiens
21 STRN4 29888
Affinity Capture-MS Homo sapiens
22 B3GNT2 10678
Affinity Capture-MS Homo sapiens
23 MCM2 4171
Affinity Capture-MS Homo sapiens
24 SPRTN  
Affinity Capture-MS Homo sapiens
25 SOSTDC1  
Affinity Capture-MS Homo sapiens
26 FAM8A1 51439
Affinity Capture-MS Homo sapiens
27 SMTN 6525
Affinity Capture-MS Homo sapiens
28 NFATC3 4775
Affinity Capture-MS Homo sapiens
29 TIAM1  
Affinity Capture-MS Homo sapiens
30 RNF2  
Affinity Capture-MS Homo sapiens
31 ANGEL1  
Affinity Capture-MS Homo sapiens
32 C2orf44  
Affinity Capture-MS Homo sapiens
33 SUN2 25777
Affinity Capture-MS Homo sapiens
34 BCOR  
Affinity Capture-MS Homo sapiens
35 STRIP1 85369
Affinity Capture-MS Homo sapiens
36 OIP5  
Affinity Capture-MS Homo sapiens
37 MYCN  
Affinity Capture-MS Homo sapiens
38 CTTNBP2NL  
Affinity Capture-MS Homo sapiens
39 USP53 54532
Affinity Capture-MS Homo sapiens
40 NPHP3 27031
Affinity Capture-MS Homo sapiens
41 NEIL3  
Protein-RNA Homo sapiens
42 TBKBP1  
Affinity Capture-MS Homo sapiens
43 DIS3L  
Affinity Capture-MS Homo sapiens
44 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ALPK1 80216
Affinity Capture-MS Homo sapiens
46 AGFG1 3267
Affinity Capture-MS Homo sapiens
47 USP11 8237
Affinity Capture-MS Homo sapiens
48 MOB4 25843
Affinity Capture-MS Homo sapiens
49 PARK2  
Affinity Capture-MS Homo sapiens
50 PPP6R2 9701
Affinity Capture-MS Homo sapiens
51 SDCCAG3  
Affinity Capture-MS Homo sapiens
52 MTFR1L 56181
Affinity Capture-MS Homo sapiens
53 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
54 MEX3C 51320
Affinity Capture-MS Homo sapiens
55 MANBA 4126
Affinity Capture-MS Homo sapiens
56 TAF9B  
Affinity Capture-MS Homo sapiens
57 MB21D2  
Affinity Capture-MS Homo sapiens
58 TRIM21 6737
Affinity Capture-MS Homo sapiens
59 SLX4  
Affinity Capture-MS Homo sapiens
60 AZI2  
Affinity Capture-MS Homo sapiens
61 KMT2E  
Affinity Capture-MS Homo sapiens
62 NOL4  
Affinity Capture-MS Homo sapiens
63 EYA4 2070
Affinity Capture-MS Homo sapiens
64 CEP76  
Affinity Capture-MS Homo sapiens
65 NFKB2 4791
Affinity Capture-MS Homo sapiens
66 DDX39B 7919
Affinity Capture-MS Homo sapiens
67 REPS1 85021
Affinity Capture-MS Homo sapiens
68 PICALM 8301
Affinity Capture-MS Homo sapiens
69 CYLD  
Affinity Capture-MS Homo sapiens
70 FGFR1OP  
Affinity Capture-MS Homo sapiens
71 KBTBD11 9920
Affinity Capture-MS Homo sapiens
72 BAG3 9531
Affinity Capture-MS Homo sapiens
73 RING1 6015
Affinity Capture-MS Homo sapiens
74 Rab5c 19345
Affinity Capture-MS Mus musculus
75 FANCD2  
Affinity Capture-MS Homo sapiens
76 CDC73  
Affinity Capture-MS Homo sapiens
77 VIPAS39 63894
Affinity Capture-MS Homo sapiens
78 UBE3A 7337
Affinity Capture-MS Homo sapiens
79 UBAP2 55833
Affinity Capture-MS Homo sapiens
80 ZGRF1 55345
Affinity Capture-MS Homo sapiens
81 ITLN2  
Affinity Capture-MS Homo sapiens
82 KIAA0232 9778
Affinity Capture-MS Homo sapiens
83 ZC3H7A  
Affinity Capture-MS Homo sapiens
84 CDK19 23097
Affinity Capture-MS Homo sapiens
85 ADNP 23394
Affinity Capture-MS Homo sapiens
86 TOP3A  
Affinity Capture-MS Homo sapiens
87 FARP2 9855
Affinity Capture-MS Homo sapiens
88 PTK2 5747
Affinity Capture-MS Homo sapiens
89 Ect2  
Affinity Capture-MS Mus musculus
90 NCAPH 23397
Affinity Capture-MS Homo sapiens
91 MYC  
Affinity Capture-MS Homo sapiens
92 NIN 51199
Affinity Capture-MS Homo sapiens
93 PHF6  
Affinity Capture-MS Homo sapiens
94 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
95 Uba1 22201
Affinity Capture-MS Mus musculus
96 AUNIP  
Affinity Capture-MS Homo sapiens
97 PCGF1 84759
Affinity Capture-MS Homo sapiens
98 Dynll1 56455
Affinity Capture-MS Mus musculus
99 Bud13  
Affinity Capture-MS Mus musculus
100 SCAPER  
Affinity Capture-MS Homo sapiens
101 CEP350 9857
Affinity Capture-MS Homo sapiens
102 RBM47 54502
Affinity Capture-MS Homo sapiens
103 ARHGEF40 55701
Affinity Capture-MS Homo sapiens
104 NCAPG 64151
Affinity Capture-MS Homo sapiens
105 RBBP8  
Affinity Capture-MS Homo sapiens
106 ARHGAP24  
Affinity Capture-MS Homo sapiens
107 RELA 5970
Affinity Capture-MS Homo sapiens
108 GRK5 2869
Affinity Capture-MS Homo sapiens
109 GIGYF2 26058
Affinity Capture-MS Homo sapiens
110 RNF220  
Affinity Capture-MS Homo sapiens
111 RAD17  
Affinity Capture-MS Homo sapiens
112 RBFA  
Affinity Capture-MS Homo sapiens
113 SLMAP 7871
Affinity Capture-MS Homo sapiens
114 USP25  
Affinity Capture-MS Homo sapiens
115 IQCC  
Affinity Capture-MS Homo sapiens
116 TP53 7157
Affinity Capture-MS Homo sapiens
117 CCHCR1  
Affinity Capture-MS Homo sapiens
118 ZBTB8A  
Affinity Capture-MS Homo sapiens
119 MCM5 4174
Affinity Capture-MS Homo sapiens
120 KANK1  
Affinity Capture-MS Homo sapiens
121 TIMM10  
Affinity Capture-MS Homo sapiens
122 ITPKC  
Affinity Capture-MS Homo sapiens
123 ZDBF2  
Affinity Capture-MS Homo sapiens
124 RMI1  
Affinity Capture-MS Homo sapiens
125 CHD4 1108
Affinity Capture-MS Homo sapiens
126 ZBTB10 65986
Affinity Capture-MS Homo sapiens
127 S100A9 6280
Affinity Capture-MS Homo sapiens
128 TBK1 29110
Affinity Capture-MS Homo sapiens
129 WWP2 11060
Affinity Capture-MS Homo sapiens
130 NCAPD2 9918
Affinity Capture-MS Homo sapiens
131 DDX3X 1654
Affinity Capture-MS Homo sapiens
132 PPP2R3C  
Affinity Capture-MS Homo sapiens
133 QRICH1  
Affinity Capture-MS Homo sapiens
134 INF2 64423
Affinity Capture-MS Homo sapiens
135 PMVK 10654
Affinity Capture-MS Homo sapiens
136 EYA1  
Affinity Capture-MS Homo sapiens
137 TCF3  
Affinity Capture-MS Homo sapiens
138 SERBP1 26135
Affinity Capture-MS Homo sapiens
139 LMLN  
Affinity Capture-MS Homo sapiens
140 CCDC88A 55704
Affinity Capture-MS Homo sapiens
141 CTNND1 1500
Affinity Capture-MS Homo sapiens
142 MIPOL1  
Affinity Capture-MS Homo sapiens
143 VPS33B 26276
Affinity Capture-MS Homo sapiens
144 ANKRD54  
Affinity Capture-MS Homo sapiens
145 RANBP2 5903
Affinity Capture-MS Homo sapiens
146 ANKLE2 23141
Affinity Capture-MS Homo sapiens
147 HUNK  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PIP is involved
PathwayEvidenceSource
Miscellaneous transport and binding events TAS Reactome
Transport of small molecules TAS Reactome





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