Gene description for CCDC88A
Gene name coiled-coil domain containing 88A
Gene symbol CCDC88A
Other names/aliases APE
GIRDIN
GIV
GRDN
HkRP1
KIAA1212
Species Homo sapiens
 Database cross references - CCDC88A
ExoCarta ExoCarta_55704
Vesiclepedia VP_55704
Entrez Gene 55704
HGNC 25523
MIM 609736
UniProt Q3V6T2  
 CCDC88A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CCDC88A
Molecular Function
    G-protein alpha-subunit binding GO:0001965 IPI
    actin binding GO:0003779 IDA
    protein kinase C binding GO:0005080 IPI
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    GDP-dissociation inhibitor activity GO:0005092 IDA
    epidermal growth factor receptor binding GO:0005154 IPI
    insulin receptor binding GO:0005158 IPI
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 ISS
    G-protein gamma-subunit binding GO:0031682 IEA
    phosphatidylinositol binding GO:0035091 IDA
    SH2 domain binding GO:0042169 IPI
    protein homodimerization activity GO:0042803 IPI
    vascular endothelial growth factor receptor 2 binding GO:0043184 IPI
    protein kinase B binding GO:0043422 IPI
    protein serine/threonine kinase activator activity GO:0043539 ISS
    dynein light intermediate chain binding GO:0051959 IBA
Biological Process
    small GTPase-mediated signal transduction GO:0007264 IDA
    nervous system development GO:0007399 IEA
    regulation of neuron projection development GO:0010975 ISS
    cell migration GO:0016477 IMP
    lamellipodium assembly GO:0030032 IMP
    cytoskeleton-dependent intracellular transport GO:0030705 IBA
    cytoplasmic microtubule organization GO:0031122 IBA
    TOR signaling GO:0031929 ISS
    activation of protein kinase activity GO:0032147 IDA
    regulation of actin cytoskeleton organization GO:0032956 IMP
    regulation of cell population proliferation GO:0042127 ISS
    positive regulation of cilium assembly GO:0045724 IMP
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IDA
    positive regulation of stress fiber assembly GO:0051496 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    membrane organization GO:0061024 IDA
    maintenance of protein location in plasma membrane GO:0072660 IDA
    positive regulation of protein localization to cilium GO:1903566 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    centrosome GO:0005813 IBA
    centriole GO:0005814 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IDA
    lamellipodium GO:0030027 IDA
    COPI-coated Golgi to ER transport vesicle GO:0030142 IEA
    cytoplasmic vesicle GO:0031410 IDA
    ciliary basal body GO:0036064 IDA
 Experiment description of studies that identified CCDC88A in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CCDC88A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CELF1 10658
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 LCK 3932
Proximity Label-MS Homo sapiens
5 AP2B1 163
Proximity Label-MS Homo sapiens
6 CLIP1 6249
Affinity Capture-MS Homo sapiens
7 OCLN 100506658
Proximity Label-MS Homo sapiens
8 PAXIP1  
Affinity Capture-MS Homo sapiens
9 AAK1 22848
Affinity Capture-MS Homo sapiens
10 MARCKS 4082
Proximity Label-MS Homo sapiens
11 GJA1 2697
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TPP1 1200
Affinity Capture-MS Homo sapiens
13 S100A6 6277
Affinity Capture-MS Homo sapiens
14 BBS7 55212
Affinity Capture-MS Homo sapiens
15 PARD3 56288
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
16 NUP62 23636
Affinity Capture-MS Homo sapiens
17 MAGEA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CALM1 801
Affinity Capture-MS Homo sapiens
19 FUBP3 8939
Affinity Capture-MS Homo sapiens
20 STX4 6810
Proximity Label-MS Homo sapiens
21 SRSF8 10929
Affinity Capture-MS Homo sapiens
22 USP36  
Affinity Capture-MS Homo sapiens
23 WDR62  
Affinity Capture-MS Homo sapiens
24 LAMTOR1 55004
Proximity Label-MS Homo sapiens
25 HDAC3 8841
Affinity Capture-MS Homo sapiens
26 CAPG 822
Affinity Capture-MS Homo sapiens
27 MLLT4 4301
Proximity Label-MS Homo sapiens
28 EXOC1 55763
Two-hybrid Homo sapiens
29 NAA11 84779
Affinity Capture-MS Homo sapiens
30 Cetn2  
Affinity Capture-MS Mus musculus
31 STX7 8417
Proximity Label-MS Homo sapiens
32 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 C11orf52 91894
Proximity Label-MS Homo sapiens
34 ARHGEF10 9639
Affinity Capture-MS Homo sapiens
35 SNX1 6642
Co-localization Homo sapiens
36 HERC2 8924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 STX6 10228
Proximity Label-MS Homo sapiens
38 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 IL17RA 23765
Affinity Capture-MS Homo sapiens
40 RAB35 11021
Proximity Label-MS Homo sapiens
41 ERBB2 2064
Affinity Capture-MS Homo sapiens
42 MAD2L1 4085
Affinity Capture-MS Homo sapiens
43 Tmed10 68581
Affinity Capture-MS Mus musculus
44 PPIP5K2 23262
Affinity Capture-MS Homo sapiens
45 KCNE3  
Affinity Capture-MS Homo sapiens
46 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 Sdccag8  
Affinity Capture-MS Mus musculus
48 HAUS2  
Affinity Capture-MS Homo sapiens
49 S100A2 6273
Affinity Capture-MS Homo sapiens
50 PKM 5315
Affinity Capture-MS Homo sapiens
51 FKBP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 LUZP1 7798
Affinity Capture-MS Homo sapiens
53 CXADR 1525
Proximity Label-MS Homo sapiens
54 PEG10 23089
Affinity Capture-MS Homo sapiens
55 LYN 4067
Proximity Label-MS Homo sapiens
56 MAPRE1 22919
Affinity Capture-MS Homo sapiens
57 MCAM 4162
Proximity Label-MS Homo sapiens
58 BAG6 7917
Affinity Capture-MS Homo sapiens
59 BRAF  
Two-hybrid Homo sapiens
60 DNAJC5 80331
Proximity Label-MS Homo sapiens
61 IWS1  
Affinity Capture-MS Homo sapiens
62 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 DIRAS3  
Proximity Label-MS Homo sapiens
64 BARD1 580
Affinity Capture-MS Homo sapiens
65 NTRK1 4914
Affinity Capture-MS Homo sapiens
66 JADE2 23338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 METTL21A  
Affinity Capture-MS Homo sapiens
68 CTNNB1 1499
Proximity Label-MS Homo sapiens
69 DCTN1 1639
Affinity Capture-Western Homo sapiens
70 YWHAQ 10971
Affinity Capture-MS Homo sapiens
71 GANAB 23193
Affinity Capture-MS Homo sapiens
72 GNAI2 2771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 AGPS 8540
Proximity Label-MS Homo sapiens
74 RFTN2 130132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 RAN 5901
Affinity Capture-MS Homo sapiens
76 BRINP3  
Affinity Capture-MS Homo sapiens
77 Pcdh1  
Affinity Capture-MS Mus musculus
78 PHLPP1  
Proximity Label-MS Homo sapiens
79 DISC1 27185
Two-hybrid Homo sapiens
80 EME1  
Affinity Capture-MS Homo sapiens
81 S100P 6286
Affinity Capture-MS Homo sapiens
82 NUP43 348995
Proximity Label-MS Homo sapiens
83 NES 10763
Affinity Capture-MS Homo sapiens
84 METTL21C  
Affinity Capture-MS Homo sapiens
85 XPO1 7514
Affinity Capture-MS Homo sapiens
86 PIP 5304
Affinity Capture-MS Homo sapiens
87 EPB41L4A 64097
Proximity Label-MS Homo sapiens
88 LAMP1 3916
Proximity Label-MS Homo sapiens
89 ANXA1 301
Affinity Capture-MS Homo sapiens
90 PTPRA 5786
Proximity Label-MS Homo sapiens
91 NUP88 4927
Affinity Capture-MS Homo sapiens
92 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 YWHAZ 7534
Affinity Capture-MS Homo sapiens
94 EGFR 1956
Co-localization Homo sapiens
95 HOOK3 84376
Proximity Label-MS Homo sapiens
96 FARP2 9855
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 FUS 2521
Affinity Capture-MS Homo sapiens
98 DUSP16  
Affinity Capture-MS Homo sapiens
99 RCN1 5954
Affinity Capture-MS Homo sapiens
100 Vps4b 20479
Affinity Capture-MS Mus musculus
101 DVL3 1857
Affinity Capture-MS Homo sapiens
102 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 MAPRE3  
Proximity Label-MS Homo sapiens
104 CEP250 11190
Affinity Capture-MS Homo sapiens
105 ARF6 382
Proximity Label-MS Homo sapiens
106 ABTB2 25841
Affinity Capture-MS Homo sapiens
107 EPHA2 1969
Proximity Label-MS Homo sapiens
108 SEC31A 22872
Affinity Capture-MS Homo sapiens
109 NUBP1 4682
Affinity Capture-MS Homo sapiens
110 RHOB 388
Proximity Label-MS Homo sapiens
111 CTNNA1 1495
Proximity Label-MS Homo sapiens
112 AKT1 207
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
113 CETN2 1069
Affinity Capture-MS Homo sapiens
114 RASSF7  
Affinity Capture-MS Homo sapiens
115 PDE3A  
Affinity Capture-MS Homo sapiens
116 IRF3 3661
Affinity Capture-MS Homo sapiens
117 FLOT1 10211
Proximity Label-MS Homo sapiens
118 HUWE1 10075
Affinity Capture-MS Homo sapiens
119 BACH2 60468
Affinity Capture-MS Homo sapiens
120 SEC24B 10427
Affinity Capture-MS Homo sapiens
121 DENND6A 201627
Proximity Label-MS Homo sapiens
122 RNF43  
Proximity Label-MS Homo sapiens
123 CCDC96  
Affinity Capture-MS Homo sapiens
124 TFDP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 CTSL 1514
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 NSF 4905
Affinity Capture-MS Homo sapiens
127 POLR2J  
Affinity Capture-MS Homo sapiens
128 PLEC 5339
Affinity Capture-MS Homo sapiens
129 URGCP 55665
Affinity Capture-MS Homo sapiens
130 TRIM52  
Affinity Capture-MS Homo sapiens
131 PRKACA 5566
Two-hybrid Homo sapiens
132 SMURF1 57154
Affinity Capture-MS Homo sapiens
133 SEPT10 151011
Proximity Label-MS Homo sapiens
134 CYTH4  
Affinity Capture-MS Homo sapiens
135 QSER1  
Affinity Capture-MS Homo sapiens
136 DDX58 23586
Affinity Capture-RNA Homo sapiens
137 LATS1  
Proximity Label-MS Homo sapiens
138 DYNC1H1 1778
Affinity Capture-Western Homo sapiens
139 C6orf141  
Affinity Capture-MS Homo sapiens
140 RBM4 5936
Affinity Capture-MS Homo sapiens
141 RBM26 64062
Affinity Capture-MS Homo sapiens
142 RAB2A 5862
Proximity Label-MS Homo sapiens
143 EYA4 2070
Affinity Capture-MS Homo sapiens
144 RAPGEF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 CEP135  
Proximity Label-MS Homo sapiens
146 RAB11A 8766
Proximity Label-MS Homo sapiens
147 DYNLRB1 83658
Affinity Capture-MS Homo sapiens
148 NDEL1 81565
Two-hybrid Homo sapiens
149 PER3  
Affinity Capture-MS Homo sapiens
150 KRAS 3845
Proximity Label-MS Homo sapiens
151 CCDC136  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 ANXA7 310
Affinity Capture-MS Homo sapiens
153 Sgol1  
Affinity Capture-MS Mus musculus
154 UBE2D2 7322
Affinity Capture-MS Homo sapiens
155 PRMT1 3276
Affinity Capture-MS Homo sapiens
156 CAV1 857
Proximity Label-MS Homo sapiens
157 GNAI3 2773
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
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