Gene description for CELF1
Gene name CUGBP, Elav-like family member 1
Gene symbol CELF1
Other names/aliases BRUNOL2
CUG-BP
CUGBP
CUGBP1
EDEN-BP
NAB50
NAPOR
hNab50
Species Homo sapiens
 Database cross references - CELF1
ExoCarta ExoCarta_10658
Entrez Gene 10658
HGNC 2549
MIM 601074
UniProt Q92879  
 CELF1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for CELF1
Molecular Function
    translation repressor activity, nucleic acid binding GO:0000900 NAS
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    mRNA binding GO:0003729 IDA
    BRE binding GO:0042835 IDA
    RNA binding GO:0003723 IDA
    translation initiation factor binding GO:0031369 IEA
Biological Process
    positive regulation of multicellular organism growth GO:0040018 IEA
    mRNA splice site selection GO:0006376 ISS
    negative regulation of translation GO:0017148 NAS
    regulation of RNA splicing GO:0043484 IDA
    spermatid development GO:0007286 IEA
    RNA interference GO:0016246 NAS
    embryo development GO:0009790 NAS
    mRNA processing GO:0006397 TAS
    germ cell development GO:0007281 NAS
Subcellular Localization
    nucleus GO:0005634 NAS
    membrane GO:0016020 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IEA
    ribonucleoprotein complex GO:0030529 NAS
 Experiment description of studies that identified CELF1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CELF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FUBP1 8880
Two-hybrid Homo sapiens
2 CELF1 10658
Invitro Homo sapiens
Invitro Homo sapiens
3 TOM1L1 10040
Two-hybrid Homo sapiens
4 PPBP 5473
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CELF1 is involved
No pathways found





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