Gene description for PPBP
Gene name pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Gene symbol PPBP
Other names/aliases B-TG1
Beta-TG
CTAP-III
CTAP3
CTAPIII
CXCL7
LA-PF4
LDGF
MDGF
NAP-2
PBP
SCYB7
TC1
TC2
TGB
TGB1
THBGB
THBGB1
Species Homo sapiens
 Database cross references - PPBP
ExoCarta ExoCarta_5473
Entrez Gene 5473
HGNC 9240
MIM 121010
UniProt P02775  
 PPBP identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for PPBP
Molecular Function
    glucose transmembrane transporter activity GO:0005355 TAS
    growth factor activity GO:0008083 IEA
    chemokine activity GO:0008009 IBA
    CXCR chemokine receptor binding GO:0045236 IBA
Biological Process
    glucose transport GO:0015758 TAS
    platelet activation GO:0030168 TAS
    G-protein coupled receptor signaling pathway GO:0007186 IBA
    positive regulation of leukocyte chemotaxis GO:0002690 IBA
    cell chemotaxis GO:0060326 IEA
    regulation of cell proliferation GO:0042127 IBA
    blood coagulation GO:0007596 TAS
    inflammatory response GO:0006954 IBA
    positive regulation of cell division GO:0051781 IEA
    leukocyte migration involved in inflammatory response GO:0002523 IEA
    immune response GO:0006955 IBA
    chemokine-mediated signaling pathway GO:0070098 IBA
    response to lipopolysaccharide GO:0032496 IBA
    defense response to bacterium GO:0042742 IEA
    platelet degranulation GO:0002576 TAS
Subcellular Localization
    extracellular space GO:0005615 IBA
    platelet alpha granule lumen GO:0031093 TAS
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified PPBP in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPBP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EFNA1  
Two-hybrid Homo sapiens
2 CELF1 10658
Two-hybrid Homo sapiens
3 CTSG 1511
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 IL8RA  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
5 COX17  
Two-hybrid Homo sapiens
6 PPBP 5473
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
7 IL8RB  
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
8 COPS7A  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PPBP is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines TAS Reactome
G alpha (i) signalling events TAS Reactome
Platelet degranulation TAS Reactome





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