Gene description for PPBP
Gene name pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Gene symbol PPBP
Other names/aliases B-TG1
Beta-TG
CTAP-III
CTAP3
CTAPIII
CXCL7
LA-PF4
LDGF
MDGF
NAP-2
PBP
SCYB7
TC1
TC2
TGB
TGB1
THBGB
THBGB1
Species Homo sapiens
 Database cross references - PPBP
ExoCarta ExoCarta_5473
Vesiclepedia VP_5473
Entrez Gene 5473
HGNC 9240
MIM 121010
UniProt P02775  
 PPBP identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for PPBP
Molecular Function
    protein binding GO:0005515 IPI
    chemokine activity GO:0008009 IBA
    growth factor activity GO:0008083 IEA
    CXCR chemokine receptor binding GO:0045236 IBA
    D-glucose transmembrane transporter activity GO:0055056 TAS
Biological Process
    inflammatory response GO:0006954 IBA
    neutrophil chemotaxis GO:0030593 IBA
    killing of cells of another organism GO:0031640 IDA
    defense response to bacterium GO:0042742 IEA
    positive regulation of cell division GO:0051781 IEA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
    cellular response to lipopolysaccharide GO:0071222 IBA
    D-glucose transmembrane transport GO:1904659 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    platelet alpha granule GO:0031091 IDA
    platelet alpha granule lumen GO:0031093 TAS
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified PPBP in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPBP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CELF1 10658
Two-hybrid Homo sapiens
2 CCL8  
Reconstituted Complex Homo sapiens
3 CXCL10  
Reconstituted Complex Homo sapiens
4 CMTM6 54918
Two-hybrid Homo sapiens
5 COX17  
Two-hybrid Homo sapiens
6 CCL13  
Reconstituted Complex Homo sapiens
7 COPS7A 50813
Two-hybrid Homo sapiens
8 NR4A1  
Two-hybrid Homo sapiens
9 CCL26  
Reconstituted Complex Homo sapiens
10 CXCL11  
Reconstituted Complex Homo sapiens
11 CXCL6  
Reconstituted Complex Homo sapiens
12 CXCL12 6387
Reconstituted Complex Homo sapiens
13 ALB 213
Affinity Capture-MS Homo sapiens
14 EFNA1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 CXCL14  
Reconstituted Complex Homo sapiens
16 PLEKHJ1  
Two-hybrid Homo sapiens
17 COPG1 22820
Two-hybrid Homo sapiens
18 RPS27 6232
Two-hybrid Homo sapiens
19 MAPK6  
Two-hybrid Homo sapiens
20 CCL5 6352
Reconstituted Complex Homo sapiens
21 MOB3B  
Two-hybrid Homo sapiens
22 CCL21  
Reconstituted Complex Homo sapiens
23 CXCL9  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
24 NDUFB11 54539
Two-hybrid Homo sapiens
25 RAB10 10890
Two-hybrid Homo sapiens
26 CCL28 56477
Reconstituted Complex Homo sapiens
27 PPBP 5473
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
View the network image/svg+xml



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