Gene description for PPBP
Gene name
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Gene symbol
PPBP
Other names/aliases
B-TG1 Beta-TG CTAP-III CTAP3 CTAPIII CXCL7 LA-PF4 LDGF MDGF NAP-2 PBP SCYB7 TC1 TC2 TGB TGB1 THBGB THBGB1
Species
Homo sapiens
Database cross references - PPBP
ExoCarta
ExoCarta_5473
Vesiclepedia
VP_5473
Entrez Gene
5473
HGNC
9240
MIM
121010
UniProt
P02775
PPBP identified in exosomes derived from the following tissue/cell type
Platelets
25332113
Platelets
25332113
Platelets
25332113
Gene ontology annotations for PPBP
Experiment description of studies that identified PPBP in exosomes
1
Experiment ID
231
MISEV standards
✘
Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
232
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
233
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PPBP
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
CELF1
10658
Two-hybrid
Homo sapiens
2
CCL8
Reconstituted Complex
Homo sapiens
3
CXCL10
Reconstituted Complex
Homo sapiens
4
CMTM6
54918
Two-hybrid
Homo sapiens
5
COX17
Two-hybrid
Homo sapiens
6
CCL13
Reconstituted Complex
Homo sapiens
7
COPS7A
50813
Two-hybrid
Homo sapiens
8
NR4A1
Two-hybrid
Homo sapiens
9
CCL26
Reconstituted Complex
Homo sapiens
10
CXCL11
Reconstituted Complex
Homo sapiens
11
CXCL6
Reconstituted Complex
Homo sapiens
12
CXCL12
6387
Reconstituted Complex
Homo sapiens
13
ALB
213
Affinity Capture-MS
Homo sapiens
14
EFNA1
Two-hybrid
Homo sapiens
Two-hybrid
Homo sapiens
15
CXCL14
Reconstituted Complex
Homo sapiens
16
PLEKHJ1
Two-hybrid
Homo sapiens
17
COPG1
22820
Two-hybrid
Homo sapiens
18
RPS27
6232
Two-hybrid
Homo sapiens
19
MAPK6
Two-hybrid
Homo sapiens
20
CCL5
6352
Reconstituted Complex
Homo sapiens
21
MOB3B
Two-hybrid
Homo sapiens
22
CCL21
Reconstituted Complex
Homo sapiens
23
CXCL9
Reconstituted Complex
Homo sapiens
Reconstituted Complex
Homo sapiens
24
NDUFB11
54539
Two-hybrid
Homo sapiens
25
RAB10
10890
Two-hybrid
Homo sapiens
26
CCL28
56477
Reconstituted Complex
Homo sapiens
27
PPBP
5473
Co-crystal Structure
Homo sapiens
Co-crystal Structure
Homo sapiens
View the network
image/svg+xml
Pathways in which PPBP is involved