Gene description for PPBP
Gene name
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Gene symbol
PPBP
Other names/aliases
B-TG1 Beta-TG CTAP-III CTAP3 CTAPIII CXCL7 LA-PF4 LDGF MDGF NAP-2 PBP SCYB7 TC1 TC2 TGB TGB1 THBGB THBGB1
Species
Homo sapiens
Database cross references - PPBP
ExoCarta
ExoCarta_5473
Vesiclepedia
VP_5473
Entrez Gene
5473
HGNC
9240
MIM
121010
UniProt
P02775
PPBP identified in exosomes derived from the following tissue/cell type
Platelets
25332113
Platelets
25332113
Platelets
25332113
Gene ontology annotations for PPBP
Experiment description of studies that identified PPBP in exosomes
1
Experiment ID
231
MISEV standards
✘
EV Biophysical techniques
✔
Alix|CD63|CD9
EV Enriched markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
232
MISEV standards
✘
EV Biophysical techniques
✘
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
233
MISEV standards
✘
EV Biophysical techniques
✘
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PPBP
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
EFNA1
Two-hybrid
Homo sapiens
2
CELF1
10658
Two-hybrid
Homo sapiens
3
CTSG
1511
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
4
IL8RA
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
5
COX17
Two-hybrid
Homo sapiens
6
COPS7A
50813
Two-hybrid
Homo sapiens
7
PPBP
5473
Affinity Capture-MS
Homo sapiens
Co-crystal Structure
Homo sapiens
Affinity Capture-MS
Homo sapiens
Co-crystal Structure
Homo sapiens
8
IL8RB
Invivo
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which PPBP is involved