Gene description for CMTM6
Gene name CKLF-like MARVEL transmembrane domain containing 6
Gene symbol CMTM6
Other names/aliases CKLFSF6
PRO2219
Species Homo sapiens
 Database cross references - CMTM6
ExoCarta ExoCarta_54918
Entrez Gene 54918
HGNC 19177
MIM 607889
UniProt Q9NX76  
 CMTM6 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for CMTM6
Molecular Function
    cytokine activity GO:0005125 IEA
Biological Process
    chemotaxis GO:0006935 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 IDA
    membrane GO:0016020 IDA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified CMTM6 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for CMTM6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CMTM6 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here