ExoCarta: Gene summary

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Gene description for COMTD1
Gene name	catechol-O-methyltransferase domain containing 1
Gene symbol	COMTD1
Other names/aliases	-
Species	Homo sapiens
Database cross references - COMTD1
ExoCarta	ExoCarta_118881
Vesiclepedia	VP_118881
Entrez Gene	118881
HGNC	26309
UniProt	Q86VU5
COMTD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for COMTD1

Molecular Function
	protein binding	GO:0005515	IPI
	O-methyltransferase activity	GO:0008171	IEA
	S-adenosylmethionine-dependent methyltransferase activity	GO:0008757	IBA
Biological Process
	methylation	GO:0032259	IEA
Subcellular Localization
	mitochondrion	GO:0005739	HTP
	membrane	GO:0016020	IEA

Experiment description of studies that identified COMTD1 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for COMTD1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

EIF4G3

8672

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

INTS4

Affinity Capture-MS

Homo sapiens

GPM6A

2823

Affinity Capture-MS

Homo sapiens

CMTM6

54918

Affinity Capture-MS

Homo sapiens

COG8

84342

Affinity Capture-MS

Homo sapiens

FAM73A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

QARS

5859

Affinity Capture-MS

Homo sapiens

OCLN

100506658

Affinity Capture-MS

Homo sapiens

PAXIP1

Two-hybrid

Homo sapiens

TTYH3

80727

Affinity Capture-MS

Homo sapiens

SLC39A4

55630

Affinity Capture-MS

Homo sapiens

IPO7

10527

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

C3orf58

205428

Affinity Capture-MS

Homo sapiens

KIAA2013

90231

Affinity Capture-MS

Homo sapiens

EIF2B2

8892

Affinity Capture-MS

Homo sapiens

KPNB1

3837

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NLRX1

79671

Affinity Capture-MS

Homo sapiens

BUB1B

Affinity Capture-MS

Homo sapiens

NABP2

Affinity Capture-MS

Homo sapiens

SETX

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KARS

3735

Affinity Capture-MS

Homo sapiens

COG2

22796

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

INTS1

26173

Affinity Capture-MS

Homo sapiens

HOOK2

Affinity Capture-MS

Homo sapiens

FAM8A1

51439

Affinity Capture-MS

Homo sapiens

GCN1L1

10985

Affinity Capture-MS

Homo sapiens

C1orf112

Affinity Capture-MS

Homo sapiens

CAB39

51719

Affinity Capture-MS

Homo sapiens

NUP160

23279

Affinity Capture-MS

Homo sapiens

APEX1

328

Affinity Capture-RNA

Homo sapiens

COG6

57511

Affinity Capture-MS

Homo sapiens

HEATR3

55027

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DARS

1615

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

USO1

8615

Affinity Capture-MS

Homo sapiens

LRRC1

55227

Affinity Capture-MS

Homo sapiens

SLC39A10

57181

Affinity Capture-MS

Homo sapiens

COQ9

Affinity Capture-MS

Homo sapiens

INIP

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SLC39A11

Affinity Capture-MS

Homo sapiens

BRAT1

221927

Affinity Capture-MS

Homo sapiens

SPAG9

9043

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DIAPH3

81624

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

STK11IP

114790

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PPP6R1

22870

Affinity Capture-MS

Homo sapiens

INTS12

Affinity Capture-MS

Homo sapiens

TFIP11

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

AGPAT2

Affinity Capture-MS

Homo sapiens

UBQLN1

29979

Two-hybrid

Homo sapiens

XPO7

23039

Affinity Capture-MS

Homo sapiens

PGRMC2

10424

Affinity Capture-MS

Homo sapiens

PPP4R2

Affinity Capture-MS

Homo sapiens

EIF2B5

8893

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CCNYL1

151195

Affinity Capture-MS

Homo sapiens

BTAF1

9044

Affinity Capture-MS

Homo sapiens

DFNA5

1687

Affinity Capture-MS

Homo sapiens

SLC30A9

10463

Affinity Capture-MS

Homo sapiens

TKFC

26007

Affinity Capture-MS

Homo sapiens

SMC2

10592

Affinity Capture-MS

Homo sapiens

COX1

4512

Affinity Capture-MS

Homo sapiens

EXOC7

23265

Affinity Capture-MS

Homo sapiens

FANCD2

Affinity Capture-MS

Homo sapiens

GEMIN2

8487

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ADSL

158

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CIAO1

9391

Affinity Capture-MS

Homo sapiens

EXOC2

55770

Affinity Capture-MS

Homo sapiens

HEATR1

55127

Affinity Capture-MS

Homo sapiens

GEMIN5

25929

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

IPO11

51194

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NUP188

23511

Affinity Capture-MS

Homo sapiens

CBWD1

55871

Affinity Capture-MS

Homo sapiens

TNPO1

3842

Affinity Capture-MS

Homo sapiens

LRIG2

Affinity Capture-MS

Homo sapiens

PHAX

Affinity Capture-MS

Homo sapiens

SMEK1

55671

Affinity Capture-MS

Homo sapiens

PHKA1

5255

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

XPO5

57510

Affinity Capture-MS

Homo sapiens

EXOC4

60412

Affinity Capture-MS

Homo sapiens

PNO1

56902

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

IPO8

10526

Affinity Capture-MS

Homo sapiens

DDX20

11218

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ATXN10

25814

Affinity Capture-MS

Homo sapiens

NCAPD3

23310

Affinity Capture-MS

Homo sapiens

TNPO2

30000

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PDS5A

23244

Affinity Capture-MS

Homo sapiens

CKAP5

9793

Affinity Capture-MS

Homo sapiens

IFRD1

3475

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TBRG4

9238

Affinity Capture-MS

Homo sapiens

XPOT

11260

Affinity Capture-MS

Homo sapiens

LRBA

987

Affinity Capture-MS

Homo sapiens

COG3

83548

Affinity Capture-MS

Homo sapiens

TUBA1C

84790

Affinity Capture-MS

Homo sapiens

TBC1D8

Affinity Capture-MS

Homo sapiens

PBXIP1

57326

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

IARS

3376

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

COG5

10466

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RANBP6

26953

Affinity Capture-MS

Homo sapiens

CCNY

219771

Affinity Capture-MS

Homo sapiens

HAUS7

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

COG4

25839

Affinity Capture-MS

Homo sapiens

100

USP28

57646

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

101

STAG2

10735

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

102

BZW1

9689

Affinity Capture-MS

Homo sapiens

103

CCNT1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

104

IPO9

55705

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

105

UPK2

7379

Affinity Capture-MS

Homo sapiens

106

TTI1

9675

Affinity Capture-MS

Homo sapiens

107

NUP37

79023

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

108

SUGP1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

109

VAPB

9217

Affinity Capture-MS

Homo sapiens

110

TBC1D15

64786

Affinity Capture-MS

Homo sapiens

111

SMEK2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

112

XPO1

7514

Affinity Capture-MS

Homo sapiens

113

SLC39A6

25800

Affinity Capture-MS

Homo sapiens

114

NCAPH2

Affinity Capture-MS

Homo sapiens

115

STK17B

9262

Affinity Capture-MS

Homo sapiens

116

GEMIN8

54960

Affinity Capture-MS

Homo sapiens

117

TNPO3

23534

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

118

HOOK3

84376

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

119

PHKG2

5261

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

120

PRMT9

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

121

KIAA1524

57650

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

122

EPRS

2058

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

CYFIP2

26999

Affinity Capture-MS

Homo sapiens

124

HIP1R

9026

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

125

NCDN

23154

Affinity Capture-MS

Homo sapiens

126

WAPAL

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

127

MSTO1

55154

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

128

XPO6

23214

Affinity Capture-MS

Homo sapiens

129

CAND1

55832

Affinity Capture-MS

Homo sapiens

130

PDCD4

27250

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

131

SAAL1

113174

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

132

XPO4

64328

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

133

MARS

4141

Affinity Capture-MS

Homo sapiens

134

GBF1

8729

Affinity Capture-MS

Homo sapiens

135

CNR2

Affinity Capture-MS

Homo sapiens

136

RGPD5

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

137

MTOR

2475

Affinity Capture-MS

Homo sapiens

138

SYVN1

84447

Affinity Capture-MS

Homo sapiens

139

PPFIBP1

8496

Affinity Capture-MS

Homo sapiens

140

EIF2B3

8891

Affinity Capture-MS

Homo sapiens

141

PPP6C

5537

Affinity Capture-MS

Homo sapiens

142

CLCC1

23155

Affinity Capture-MS

Homo sapiens

143

NCAPG2

54892

Affinity Capture-MS

Homo sapiens

144

EIF2B1

1967

Affinity Capture-MS

Homo sapiens

145

DYM

Affinity Capture-MS

Homo sapiens

146

THADA

63892

Affinity Capture-MS

Homo sapiens

147

TBC1D9B

23061

Affinity Capture-MS

Homo sapiens

148

UPF2

26019

Two-hybrid

Homo sapiens

149

ANKRD28

23243

Affinity Capture-MS

Homo sapiens

150

AKAP1

8165

Proximity Label-MS

Homo sapiens

151

AIMP1

9255

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

152

ECE1

1889

Affinity Capture-MS

Homo sapiens

153

TARSL2

123283

Affinity Capture-MS

Homo sapiens

154

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

155

NUP107

57122

Affinity Capture-MS

Homo sapiens

156

SYNGR2

9144

Affinity Capture-MS

Homo sapiens

157

NUP205

23165

Affinity Capture-MS

Homo sapiens

158

NUP133

55746

Affinity Capture-MS

Homo sapiens

159

VPS28

51160

Affinity Capture-MS

Homo sapiens

160

GPN3

Affinity Capture-MS

Homo sapiens

161

KNTC1

9735

Affinity Capture-MS

Homo sapiens

162

COG1

9382

Affinity Capture-MS

Homo sapiens

163

PEX19

5824

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

164

GEMIN6

Affinity Capture-MS

Homo sapiens

165

SMC4

10051

Affinity Capture-MS

Homo sapiens

166

FBXL16

Affinity Capture-MS

Homo sapiens

167

DNAAF5

54919

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

168

INTS2

Affinity Capture-MS

Homo sapiens

169

SMN2

6607

Affinity Capture-MS

Homo sapiens

170

SLC39A14

23516

Affinity Capture-MS

Homo sapiens

171

VAC14

55697

Affinity Capture-MS

Homo sapiens

172

GEMIN4

50628

Affinity Capture-MS

Homo sapiens

173

NUP98

4928

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

174

FAM96B

51647

Affinity Capture-MS

Homo sapiens

175

CSE1L

1434

Affinity Capture-MS

Homo sapiens

176

ZW10

9183

Affinity Capture-MS

Homo sapiens

177

UFL1

23376

Affinity Capture-MS

Homo sapiens

178

TUBA1A

7846

Affinity Capture-MS

Homo sapiens

179

NCAPD2

9918

Affinity Capture-MS

Homo sapiens

180

MMS19

64210

Affinity Capture-MS

Homo sapiens

181

IPO4

79711

Affinity Capture-MS

Homo sapiens

182

EIF2B4

8890

Affinity Capture-MS

Homo sapiens

183

CDK5RAP3

80279

Affinity Capture-MS

Homo sapiens

184

PGM3

5238

Affinity Capture-MS

Homo sapiens

185

INTS3

65123

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

186

RARS

5917

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

187

NUP85

79902

Affinity Capture-MS

Homo sapiens

188

COG7

91949

Affinity Capture-MS

Homo sapiens

189

VPS8

23355

Affinity Capture-MS

Homo sapiens

190

CAMK1

8536

Affinity Capture-MS

Homo sapiens

191

RANBP2

5903

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

View the network

Pathways in which COMTD1 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here