Gene description for XPO6
Gene name exportin 6
Gene symbol XPO6
Other names/aliases EXP6
RANBP20
Species Homo sapiens
 Database cross references - XPO6
ExoCarta ExoCarta_23214
Vesiclepedia VP_23214
Entrez Gene 23214
HGNC 19733
MIM 608411
UniProt Q96QU8  
 XPO6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for XPO6
Molecular Function
    nuclear export signal receptor activity GO:0005049 IDA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
Biological Process
    protein export from nucleus GO:0006611 IBA
    protein export from nucleus GO:0006611 IDA
Subcellular Localization
    nucleus GO:0005634 IC
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IC
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified XPO6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for XPO6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRF2  
Affinity Capture-MS Homo sapiens
2 GYPA  
Affinity Capture-MS Homo sapiens
3 SLC27A2 11001
Affinity Capture-MS Homo sapiens
4 CD40 958
Affinity Capture-MS Homo sapiens
5 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 OCIAD1 54940
Affinity Capture-MS Homo sapiens
9 CYB5B 80777
Affinity Capture-MS Homo sapiens
10 EFNA4  
Affinity Capture-MS Homo sapiens
11 CSTF1 1477
Co-fractionation Homo sapiens
12 ARSF 416
Affinity Capture-MS Homo sapiens
13 GPR17 2840
Affinity Capture-MS Homo sapiens
14 GSK3B 2932
Affinity Capture-MS Homo sapiens
15 BTNL9  
Affinity Capture-MS Homo sapiens
16 PES1 23481
Affinity Capture-MS Homo sapiens
17 OPALIN  
Affinity Capture-MS Homo sapiens
18 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 HCST  
Affinity Capture-MS Homo sapiens
20 FCGRT 2217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MAPK1 5594
Co-fractionation Homo sapiens
22 PFN1 5216
Affinity Capture-MS Homo sapiens
23 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 PFKM 5213
Co-fractionation Homo sapiens
25 NPTN 27020
Affinity Capture-MS Homo sapiens
26 NUP62 23636
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
27 PTPRA 5786
Affinity Capture-MS Homo sapiens
28 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 DNAAF5 54919
Co-fractionation Homo sapiens
31 FPR1  
Affinity Capture-MS Homo sapiens
32 EFNB1 1947
Affinity Capture-MS Homo sapiens
33 RASSF1  
Affinity Capture-MS Homo sapiens
34 NPY2R  
Affinity Capture-MS Homo sapiens
35 EGFR 1956
Affinity Capture-MS Homo sapiens
36 GPRC5D  
Affinity Capture-MS Homo sapiens
37 ZMAT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 VASP 7408
Affinity Capture-MS Homo sapiens
39 ILVBL 10994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
41 PVR 5817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ATP2B4 493
Affinity Capture-MS Homo sapiens
43 MLST8 64223
Affinity Capture-MS Homo sapiens
44 COMTD1 118881
Affinity Capture-MS Homo sapiens
45 ACTA1 58
Affinity Capture-MS Homo sapiens
46 DCUN1D1 54165
Co-fractionation Homo sapiens
47 C3orf18  
Affinity Capture-MS Homo sapiens
48 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SEC62 7095
Affinity Capture-MS Homo sapiens
50 C16orf58 64755
Affinity Capture-MS Homo sapiens
51 RAN 5901
Affinity Capture-MS Homo sapiens
52 PPP2R5D 5528
Co-fractionation Homo sapiens
53 KIR2DL4  
Affinity Capture-MS Homo sapiens
54 MTOR 2475
Affinity Capture-MS Homo sapiens
55 SMAD3 4088
Reconstituted Complex Homo sapiens
56 GPR182  
Affinity Capture-MS Homo sapiens
57 PTPRN  
Affinity Capture-MS Homo sapiens
58 TPST2 8459
Affinity Capture-MS Homo sapiens
59 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 SNW1 22938
Affinity Capture-MS Homo sapiens
62 VIPR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 C5AR1  
Affinity Capture-MS Homo sapiens
64 P2RY10  
Affinity Capture-MS Homo sapiens
65 VPS39 23339
Co-fractionation Homo sapiens
66 STK4 6789
Affinity Capture-MS Homo sapiens
67 DIAPH1 1729
Affinity Capture-MS Homo sapiens
68 FXYD3 5349
Affinity Capture-MS Homo sapiens
69 ITFG3 83986
Affinity Capture-MS Homo sapiens
70 THADA 63892
Affinity Capture-MS Homo sapiens
71 RPA3 6119
Proximity Label-MS Homo sapiens
72 ENAH 55740
Affinity Capture-MS Homo sapiens
73 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 RANBP17  
Co-fractionation Homo sapiens
75 TACSTD2 4070
Affinity Capture-MS Homo sapiens
76 UBXN6 80700
Co-fractionation Homo sapiens
77 CACNG6  
Affinity Capture-MS Homo sapiens
78 AVPR2  
Affinity Capture-MS Homo sapiens
79 HYPM  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which XPO6 is involved
No pathways found





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