Gene description for CD274
Gene name CD274 molecule
Gene symbol CD274
Other names/aliases B7-H
B7H1
PD-L1
PDCD1L1
PDCD1LG1
PDL1
Species Homo sapiens
 Database cross references - CD274
ExoCarta ExoCarta_29126
Vesiclepedia VP_29126
Entrez Gene 29126
HGNC 17635
MIM 605402
UniProt Q9NZQ7  
 CD274 identified in sEVs derived from the following tissue/cell type
Breast cancer cells 30089911    
Breast cancer cells 30089911    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 36482876    
Lung cancer cells 30089911    
Lung cancer cells 30089911    
Lung cancer cells 30089911    
Lung cancer cells 30089911    
Lung cancer cells 30089911    
Lung cancer cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Melanoma cells 30089911    
Plasma 17076679    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Plasma 30089911    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CD274
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    receptor ligand activity GO:0048018 IDA
Biological Process
    adaptive immune response GO:0002250 IEA
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 IDA
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 IMP
    immune response GO:0006955 IBA
    immune response GO:0006955 IDA
    signal transduction GO:0007165 IDA
    cell surface receptor signaling pathway GO:0007166 IBA
    cell surface receptor signaling pathway GO:0007166 IDA
    positive regulation of cell migration GO:0030335 IEA
    T cell costimulation GO:0031295 IBA
    T cell costimulation GO:0031295 IDA
    negative regulation of type II interferon production GO:0032689 IMP
    negative regulation of interleukin-10 production GO:0032693 IMP
    positive regulation of interleukin-10 production GO:0032733 IDA
    response to cytokine GO:0034097 IDA
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 IDA
    positive regulation of T cell proliferation GO:0042102 IBA
    positive regulation of T cell proliferation GO:0042102 TAS
    negative regulation of T cell proliferation GO:0042130 IBA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    regulation of activated T cell proliferation GO:0046006 IMP
    negative regulation of activated T cell proliferation GO:0046007 IMP
    regulation of T cell apoptotic process GO:0070232 IMP
    cellular response to lipopolysaccharide GO:0071222 IBA
    negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556 IMP
    regulation of activated CD4-positive, alpha-beta T cell apoptotic process GO:1905399 IDA
    positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process GO:1905404 IDA
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 IDA
    negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186 IDA
    negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    actin cytoskeleton GO:0015629 IDA
    early endosome membrane GO:0031901 IDA
    recycling endosome membrane GO:0055038 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CD274 in sEVs
1
Experiment ID 989
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
2
Experiment ID 990
MISEV standards
✘ Biophysical techniques
✔
CD63|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
3
Experiment ID 542
MISEV standards
✘ Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299-fraction 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
4
Experiment ID 543
MISEV standards
✘ Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299-fraction 4
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
5
Experiment ID 544
MISEV standards
✘ Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299-fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
6
Experiment ID 546
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|GAPDH
Enriched markers
✔
GOLGA2
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
7
Experiment ID 547
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
8
Experiment ID 548
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
9
Experiment ID 549
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
10
Experiment ID 550
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
11
Experiment ID 551
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
12
Experiment ID 554
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
13
Experiment ID 555
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
14
Experiment ID 556
MISEV standards
✘ Biophysical techniques
✔
CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
15
Experiment ID 557
MISEV standards
✘ Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975-fraction 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
16
Experiment ID 558
MISEV standards
✘ Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975-fraction 4
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
17
Experiment ID 559
MISEV standards
✘ Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975-fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
18
Experiment ID 560
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
19
Experiment ID 561
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
20
Experiment ID 562
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
21
Experiment ID 563
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
22
Experiment ID 564
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
23
Experiment ID 565
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
24
Experiment ID 566
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
25
Experiment ID 567
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
26
Experiment ID 568
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36482876    
Organism Homo sapiens
Experiment description Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels
Authors "Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H."
Journal name J Extracell Vesicles
Publication year 2022
Sample Lung cancer cells
Sample name H1975
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
27
Experiment ID 986
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
28
Experiment ID 987
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Lung cancer cells
Sample name H358
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
29
Experiment ID 988
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Lung cancer cells
Sample name H1264
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
30
Experiment ID 991
MISEV standards
✘ Biophysical techniques
✔
CD63|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Lung cancer cells
Sample name H1299
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
31
Experiment ID 992
MISEV standards
✘ Biophysical techniques
✔
CD63|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Lung cancer cells
Sample name H358
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
32
Experiment ID 993
MISEV standards
✘ Biophysical techniques
✔
CD63|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Lung cancer cells
Sample name H1264
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
33
Experiment ID 955
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
Reverse phase protein array
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name A375
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Reverse phase protein array
34
Experiment ID 956
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
Reverse phase protein array
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name UACC-903
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Reverse phase protein array
35
Experiment ID 957
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
Reverse phase protein array
Immuno-EM
ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Reverse phase protein array
Immuno-EM
ELISA
36
Experiment ID 958
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
Reverse phase protein array
ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM164
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Reverse phase protein array
ELISA
37
Experiment ID 959
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Reverse phase protein array
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM1552C
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Reverse phase protein array
38
Experiment ID 960
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Reverse phase protein array
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM35
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Reverse phase protein array
39
Experiment ID 961
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Reverse phase protein array
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM793
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Reverse phase protein array
40
Experiment ID 962
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Reverse phase protein array
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM902B
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Reverse phase protein array
41
Experiment ID 963
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9 - Fraction 6
Isolation/purification methods Differential centrifugation
Iodixanol density gradient centrifugation
Ultracentrifugation
Flotation density 1.131 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
42
Experiment ID 964
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9 - Fraction 7
Isolation/purification methods Differential centrifugation
Iodixanol density gradient centrifugation
Ultracentrifugation
Flotation density 1.144 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
43
Experiment ID 965
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9 - Fraction 8
Isolation/purification methods Differential centrifugation
Iodixanol density gradient centrifugation
Ultracentrifugation
Flotation density 1.156 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
44
Experiment ID 966
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9 - Fraction 9
Isolation/purification methods Differential centrifugation
Iodixanol density gradient centrifugation
Ultracentrifugation
Flotation density 1.178 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
45
Experiment ID 967
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9 - Fraction 10
Isolation/purification methods Differential centrifugation
Iodixanol density gradient centrifugation
Ultracentrifugation
Flotation density 1.193 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
46
Experiment ID 969
MISEV standards
✘ Biophysical techniques
✔
CD63|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
ELISA
47
Experiment ID 970
MISEV standards
✘ Biophysical techniques
✔
CD63|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM164
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
ELISA
48
Experiment ID 971
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
49
Experiment ID 972
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
50
Experiment ID 973
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
51
Experiment ID 974
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
52
Experiment ID 975
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
53
Experiment ID 976
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
54
Experiment ID 985
MISEV standards
✘ Biophysical techniques
✔
CD63|TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Reverse phase protein array
Western blotting
ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Melanoma cells
Sample name MEL624
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Reverse phase protein array
Western blotting
ELISA
55
Experiment ID 43
MISEV standards
✔
EM
Biophysical techniques
✔
CD83
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 17076679    
Organism Homo sapiens
Experiment description Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences.
Authors "Sabapatha A, Gercel-Taylor C, Taylor DD"
Journal name AJRI
Publication year 2006
Sample Plasma
Sample name Plasma - Pregnant and not-pregnant women
Isolation/purification methods "Size exclusion
Ultracentrifugation
Immunobeads (CD3, CD19, CD56, CD83, PLAP)"
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
56
Experiment ID 977
MISEV standards
✘ Biophysical techniques
✔
TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Healthy donors
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
ELISA
57
Experiment ID 978
MISEV standards
✘ Biophysical techniques
✔
TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma stage IV patients
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
ELISA
58
Experiment ID 979
MISEV standards
✘ Biophysical techniques
✔
TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma stage IV patients - Fraction 7
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density 1.44 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
59
Experiment ID 980
MISEV standards
✘ Biophysical techniques
✔
TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma stage IV patients - Fraction 8
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density 1.56 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
60
Experiment ID 981
MISEV standards
✘ Biophysical techniques
✔
TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma stage IV patients - Fraction 9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density 1.178 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
61
Experiment ID 982
MISEV standards
✘ Biophysical techniques
✔
TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma stage IV patients - Fraction 10
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density 1.193 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
62
Experiment ID 983
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Athymic nude mice implanted with WM9
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
63
Experiment ID 994
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patient - Pembrolizumab responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
64
Experiment ID 995
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patient - Pembrolizumab non-responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
65
Experiment ID 996
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patient
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
66
Experiment ID 997
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
67
Experiment ID 998
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
68
Experiment ID 999
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
69
Experiment ID 1000
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
70
Experiment ID 1001
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
71
Experiment ID 1002
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
72
Experiment ID 1003
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
73
Experiment ID 1004
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
74
Experiment ID 1005
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab non-responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
75
Experiment ID 1006
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab non-responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
76
Experiment ID 1007
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab non-responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
77
Experiment ID 1008
MISEV standards
✘ Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 30089911    
Organism Homo sapiens
Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Authors "Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W."
Journal name Nature
Publication year 2018
Sample Plasma
Sample name Melanoma patients - Pembrolizumab non-responders
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
78
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
79
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
80
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD274
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 ATR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LDHA 3939
Affinity Capture-MS Homo sapiens
4 MCM7 4176
Affinity Capture-MS Homo sapiens
5 DSP 1832
Affinity Capture-MS Homo sapiens
6 TMCO1 54499
Affinity Capture-MS Homo sapiens
7 EXOC1 55763
Affinity Capture-MS Homo sapiens
8 ORC4  
Affinity Capture-MS Homo sapiens
9 WDR3  
Affinity Capture-MS Homo sapiens
10 GART 2618
Affinity Capture-MS Homo sapiens
11 SIAH2 6478
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 DHCR24 1718
Affinity Capture-MS Homo sapiens
13 PTMA 5757
Affinity Capture-MS Homo sapiens
14 IPO7 10527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TNPO1 3842
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TPX2  
Affinity Capture-MS Homo sapiens
17 PDCD1  
Reconstituted Complex Homo sapiens
18 UCHL1 7345
Affinity Capture-MS Homo sapiens
19 TTI1 9675
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SRPR 6734
Affinity Capture-MS Homo sapiens
21 USP9X 8239
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
22 KARS 3735
Affinity Capture-MS Homo sapiens
23 SLC25A1 6576
Affinity Capture-MS Homo sapiens
24 CSNK2A1 1457
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
25 CSTA 1475
Affinity Capture-MS Homo sapiens
26 BASP1 10409
Affinity Capture-MS Homo sapiens
27 COG2 22796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SEPT2 4735
Affinity Capture-MS Homo sapiens
29 FKBP4 2288
Affinity Capture-MS Homo sapiens
30 CFL1 1072
Affinity Capture-MS Homo sapiens
31 PARK7 11315
Affinity Capture-MS Homo sapiens
32 AZGP1 563
Affinity Capture-MS Homo sapiens
33 GCN1L1 10985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PRKDC 5591
Affinity Capture-MS Homo sapiens
35 PI4KA 5297
Affinity Capture-MS Homo sapiens
36 ALYREF 10189
Affinity Capture-MS Homo sapiens
37 SFPQ 6421
Affinity Capture-MS Homo sapiens
38 HAL 3034
Affinity Capture-MS Homo sapiens
39 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
40 APEX1 328
Affinity Capture-MS Homo sapiens
41 TELO2 9894
Affinity Capture-MS Homo sapiens
42 GNG12 55970
Affinity Capture-MS Homo sapiens
43 GSDMA 284110
Affinity Capture-MS Homo sapiens
44 CRACR2A  
Affinity Capture-MS Homo sapiens
45 PRDX3 10935
Affinity Capture-MS Homo sapiens
46 RINT1 60561
Affinity Capture-MS Homo sapiens
47 CHP1 11261
Affinity Capture-MS Homo sapiens
48 FABP5 2171
Affinity Capture-MS Homo sapiens
49 SLC39A11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 BRAT1 221927
Affinity Capture-MS Homo sapiens
51 PSMB5 5693
Affinity Capture-MS Homo sapiens
52 COPS5 10987
Biochemical Activity Homo sapiens
53 GNB1 2782
Affinity Capture-MS Homo sapiens
54 MDH1 4190
Affinity Capture-MS Homo sapiens
55 HSPH1 10808
Affinity Capture-MS Homo sapiens
56 ABCD3 5825
Affinity Capture-MS Homo sapiens
57 PSMB6 5694
Affinity Capture-MS Homo sapiens
58 SSR1 6745
Affinity Capture-MS Homo sapiens
59 RER1 11079
Affinity Capture-MS Homo sapiens
60 HMGA1 3159
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
61 GGCT 79017
Affinity Capture-MS Homo sapiens
62 ABCE1 6059
Affinity Capture-MS Homo sapiens
63 XPO7 23039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PNPLA2  
Affinity Capture-MS Homo sapiens
65 STIP1 10963
Affinity Capture-MS Homo sapiens
66 PGD 5226
Affinity Capture-MS Homo sapiens
67 RCC1 1104
Affinity Capture-MS Homo sapiens
68 FAF1 11124
Affinity Capture-MS Homo sapiens
69 UTP20 27340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 MTDH 92140
Affinity Capture-MS Homo sapiens
71 NAP1L4 4676
Affinity Capture-MS Homo sapiens
72 CALR 811
Affinity Capture-MS Homo sapiens
73 SEC23A 10484
Affinity Capture-MS Homo sapiens
74 CUL1 8454
Affinity Capture-Western Homo sapiens
75 BTRC 8945
Affinity Capture-Western Homo sapiens
76 NMT1 4836
Affinity Capture-MS Homo sapiens
77 USP7 7874
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
78 UBQLN4 56893
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
79 PLS3 5358
Affinity Capture-MS Homo sapiens
80 NEDD4 4734
Affinity Capture-Western Homo sapiens
81 UBE3C 9690
Affinity Capture-MS Homo sapiens
82 CSNK2A3 283106
Affinity Capture-MS Homo sapiens
83 GSK3B 2932
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
84 PDS5B 23047
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 SFXN1 94081
Affinity Capture-MS Homo sapiens
86 CLASP2 23122
Affinity Capture-MS Homo sapiens
87 EMC1 23065
Affinity Capture-MS Homo sapiens
88 LMAN1 3998
Affinity Capture-MS Homo sapiens
89 USP22 23326
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
90 ARHGDIA 396
Affinity Capture-MS Homo sapiens
91 THADA 63892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 LRRC59 55379
Affinity Capture-MS Homo sapiens
93 NSUN2 54888
Affinity Capture-MS Homo sapiens
94 RAD23B 5887
Affinity Capture-MS Homo sapiens
95 RNF144A  
Affinity Capture-Western Homo sapiens
96 PPIB 5479
Affinity Capture-MS Homo sapiens
97 DSG1 1828
Affinity Capture-MS Homo sapiens
98 PKM 5315
Affinity Capture-MS Homo sapiens
99 TMX1 81542
Affinity Capture-MS Homo sapiens
100 PHB 5245
Affinity Capture-MS Homo sapiens
101 CTBP1 1487
Affinity Capture-MS Homo sapiens
102 ARG1 383
Affinity Capture-MS Homo sapiens
103 COPG1 22820
Affinity Capture-MS Homo sapiens
104 ATP2A3 489
Affinity Capture-MS Homo sapiens
105 NONO 4841
Affinity Capture-MS Homo sapiens
106 OAT 4942
Affinity Capture-MS Homo sapiens
107 SRRT 51593
Affinity Capture-MS Homo sapiens
108 VRK1 7443
Affinity Capture-MS Homo sapiens
109 DEK 7913
Affinity Capture-MS Homo sapiens
110 TNPO2 30000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 PPA1 5464
Affinity Capture-MS Homo sapiens
112 PHB2 11331
Affinity Capture-MS Homo sapiens
113 RRM1 6240
Affinity Capture-MS Homo sapiens
114 TNPO3 23534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
116 RPL13A 23521
Affinity Capture-MS Homo sapiens
117 PARP1 142
Affinity Capture-MS Homo sapiens
118 MOGS 7841
Affinity Capture-MS Homo sapiens
119 CXorf57  
Affinity Capture-MS Homo sapiens
120 LRBA 987
Affinity Capture-MS Homo sapiens
121 COG3 83548
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 GANAB 23193
Affinity Capture-MS Homo sapiens
123 TGM1 7051
Affinity Capture-MS Homo sapiens
124 KCTD12 115207
Affinity Capture-MS Homo sapiens
125 VCL 7414
Affinity Capture-MS Homo sapiens
126 DNM2 1785
Affinity Capture-MS Homo sapiens
127 MTHFD1 4522
Affinity Capture-MS Homo sapiens
128 CAPN1 823
Affinity Capture-MS Homo sapiens
129 EIF2S3 1968
Affinity Capture-MS Homo sapiens
130 COG5 10466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 ITCH 83737
Affinity Capture-Western Homo sapiens
132 SND1 27044
Affinity Capture-MS Homo sapiens
133 CORO1C 23603
Affinity Capture-MS Homo sapiens
134 PPM1G 5496
Affinity Capture-MS Homo sapiens
135 COG4 25839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 PSMD12 5718
Affinity Capture-MS Homo sapiens
137 BZW1 9689
Affinity Capture-MS Homo sapiens
138 HMGB2 3148
Affinity Capture-MS Homo sapiens
139 C1orf68 100129271
Affinity Capture-MS Homo sapiens
140 HSP90B1 7184
Affinity Capture-MS Homo sapiens
141 ZNF326 284695
Affinity Capture-MS Homo sapiens
142 SERPINB12 89777
Affinity Capture-MS Homo sapiens
143 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
144 CAT 847
Affinity Capture-MS Homo sapiens
145 CASP14 23581
Affinity Capture-MS Homo sapiens
146 PTPN11 5781
Affinity Capture-Western Homo sapiens
147 ACAT1 38
Affinity Capture-MS Homo sapiens
148 PSMA3 5684
Affinity Capture-MS Homo sapiens
149 SERPINB3 6317
Affinity Capture-MS Homo sapiens
150 S100A14 57402
Affinity Capture-MS Homo sapiens
151 DIS3 22894
Affinity Capture-MS Homo sapiens
152 HADHA 3030
Affinity Capture-MS Homo sapiens
153 AIFM1 9131
Affinity Capture-MS Homo sapiens
154 DHCR7 1717
Affinity Capture-MS Homo sapiens
155 TPR 7175
Affinity Capture-MS Homo sapiens
156 HSPE1 3336
Affinity Capture-MS Homo sapiens
157 S100A16 140576
Affinity Capture-MS Homo sapiens
158 ASAH1 427
Affinity Capture-MS Homo sapiens
159 GGH 8836
Affinity Capture-MS Homo sapiens
160 MARCH8  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
161 ANXA1 301
Protein-peptide Homo sapiens
162 PSMD6 9861
Affinity Capture-MS Homo sapiens
163 PCNP 57092
Affinity Capture-MS Homo sapiens
164 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 CUL3 8452
Affinity Capture-Western Homo sapiens
166 TMEM160 54958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
167 PDIA3 2923
Affinity Capture-MS Homo sapiens
168 ATM 472
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 ETF1 2107
Affinity Capture-MS Homo sapiens
170 SLC7A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 FUS 2521
Affinity Capture-MS Homo sapiens
172 KIAA1524 57650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 EEF1B2 1933
Affinity Capture-MS Homo sapiens
174 LOR  
Affinity Capture-MS Homo sapiens
175 RAB35 11021
Affinity Capture-MS Homo sapiens
176 HIP1R 9026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 WFS1 7466
Affinity Capture-MS Homo sapiens
178 NXF1 10482
Affinity Capture-MS Homo sapiens
179 COG1 9382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 SPRR2A  
Affinity Capture-MS Homo sapiens
181 ECI2 10455
Affinity Capture-MS Homo sapiens
182 ACTR1A 10121
Affinity Capture-MS Homo sapiens
183 SAAL1 113174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 XPO4 64328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 XPOT 11260
Affinity Capture-MS Homo sapiens
186 CKMT1B 1159
Affinity Capture-MS Homo sapiens
187 PSPC1 55269
Affinity Capture-MS Homo sapiens
188 ACP1 52
Affinity Capture-MS Homo sapiens
189 COG8 84342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 DHRS7B 25979
Affinity Capture-MS Homo sapiens
191 MTOR 2475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 DOLK 22845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 TOP1 7150
Affinity Capture-MS Homo sapiens
194 BLMH 642
Affinity Capture-MS Homo sapiens
195 EEF1A2 1917
Affinity Capture-MS Homo sapiens
196 EXOC7 23265
Affinity Capture-MS Homo sapiens
197 VARS2  
Affinity Capture-MS Homo sapiens
198 STMN1 3925
Affinity Capture-MS Homo sapiens
199 FKBP3 2287
Affinity Capture-MS Homo sapiens
200 SYNGR2 9144
Affinity Capture-MS Homo sapiens
201 EDF1 8721
Affinity Capture-MS Homo sapiens
202 EIF2S2 8894
Affinity Capture-MS Homo sapiens
203 TXNDC5 81567
Affinity Capture-MS Homo sapiens
204 PGAM1 5223
Affinity Capture-MS Homo sapiens
205 MSN 4478
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
206 HEATR1 55127
Affinity Capture-MS Homo sapiens
207 NELFB 25920
Affinity Capture-MS Homo sapiens
208 FAM114A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 SGTA 6449
Affinity Capture-MS Homo sapiens
210 ALOX12B  
Affinity Capture-MS Homo sapiens
211 MAGT1 84061
Affinity Capture-MS Homo sapiens
212 NEDD4L 23327
Affinity Capture-Western Homo sapiens
213 HUWE1 10075
Affinity Capture-MS Homo sapiens
214 TPM3 7170
Affinity Capture-MS Homo sapiens
215 RAB11A 8766
Affinity Capture-MS Homo sapiens
216 EXOC5 10640
Affinity Capture-MS Homo sapiens
217 PA2G4 5036
Affinity Capture-MS Homo sapiens
218 LBR 3930
Affinity Capture-MS Homo sapiens
219 EIF2S1 1965
Affinity Capture-MS Homo sapiens
220 DDX50 79009
Affinity Capture-MS Homo sapiens
221 GLUD1 2746
Affinity Capture-MS Homo sapiens
222 PRKCSH 5589
Affinity Capture-MS Homo sapiens
223 TMED10 10972
Affinity Capture-MS Homo sapiens
224 SPOP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
225 KIF14 9928
Affinity Capture-MS Homo sapiens
226 IDH3B 3420
Affinity Capture-MS Homo sapiens
227 GDI2 2665
Affinity Capture-MS Homo sapiens
228 TECR 9524
Affinity Capture-MS Homo sapiens
229 HMGB1 3146
Affinity Capture-MS Homo sapiens
230 XPO6 23214
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
231 FAF2 23197
Affinity Capture-MS Homo sapiens
232 SEC16A 9919
Affinity Capture-MS Homo sapiens
233 VAC14 55697
Affinity Capture-MS Homo sapiens
234 NME4 4833
Affinity Capture-MS Homo sapiens
235 HSD17B4 3295
Affinity Capture-MS Homo sapiens
236 SEC23B 10483
Affinity Capture-MS Homo sapiens
237 EZR 7430
Affinity Capture-MS Homo sapiens
238 LSM14A 26065
Affinity Capture-MS Homo sapiens
239 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
240 YWHAB 7529
Affinity Capture-MS Homo sapiens
241 DSC1 1823
Affinity Capture-MS Homo sapiens
242 INTS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
243 TCERG1 10915
Affinity Capture-MS Homo sapiens
244 MDH2 4191
Affinity Capture-MS Homo sapiens
245 CAND1 55832
Affinity Capture-MS Homo sapiens
246 TKT 7086
Affinity Capture-MS Homo sapiens
247 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
248 SHMT2 6472
Affinity Capture-MS Homo sapiens
249 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
250 FARSB 10056
Affinity Capture-MS Homo sapiens
251 GOT2 2806
Affinity Capture-MS Homo sapiens
252 SSBP1 6742
Affinity Capture-MS Homo sapiens
253 PSMA1 5682
Affinity Capture-MS Homo sapiens
254 MTSS1 9788
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
255 FAR1 84188
Affinity Capture-MS Homo sapiens
256 STAG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
257 NF1 4763
Affinity Capture-MS Homo sapiens
258 TBRG4 9238
Affinity Capture-MS Homo sapiens
259 MINPP1 9562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
260 TGM3 7053
Affinity Capture-MS Homo sapiens
261 FARSA 2193
Affinity Capture-MS Homo sapiens
262 PTPN1 5770
Affinity Capture-MS Homo sapiens
263 PSMA7 5688
Affinity Capture-MS Homo sapiens
264 PRDX2 7001
Affinity Capture-MS Homo sapiens
265 ACACA 31
Affinity Capture-MS Homo sapiens
266 RAB7A 7879
Affinity Capture-MS Homo sapiens
267 B2M 567
Affinity Capture-MS Homo sapiens
268 CYB5R3 1727
Affinity Capture-MS Homo sapiens
269 CDK5RAP3 80279
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
270 NCCRP1 342897
Affinity Capture-MS Homo sapiens
271 PYCR1 5831
Affinity Capture-MS Homo sapiens
272 C1QBP 708
Affinity Capture-MS Homo sapiens
273 UHRF1 29128
Affinity Capture-MS Homo sapiens
274 ECM1 1893
Affinity Capture-MS Homo sapiens
275 USP51  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
276 SRP9 6726
Affinity Capture-MS Homo sapiens
277 ANXA2 302
Affinity Capture-MS Homo sapiens
278 CKAP4 10970
Affinity Capture-MS Homo sapiens
279 NUP85 79902
Affinity Capture-MS Homo sapiens
280 PSMC4 5704
Affinity Capture-MS Homo sapiens
281 DNMT1 1786
Affinity Capture-MS Homo sapiens
282 COG7 91949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
283 ACBD3 64746
Affinity Capture-MS Homo sapiens
284 PSMD8 5714
Affinity Capture-MS Homo sapiens
285 FDFT1 2222
Affinity Capture-MS Homo sapiens
286 SPCS2 9789
Affinity Capture-MS Homo sapiens
287 FLG2 388698
Affinity Capture-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here