Gene description for FAR1
Gene name fatty acyl CoA reductase 1
Gene symbol FAR1
Other names/aliases MLSTD2
PFCRD
SDR10E1
Species Homo sapiens
 Database cross references - FAR1
ExoCarta ExoCarta_84188
Vesiclepedia VP_84188
Entrez Gene 84188
HGNC 26222
MIM 616107
UniProt Q8WVX9  
 FAR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FAR1
Molecular Function
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 TAS
    alcohol-forming very long-chain fatty acyl-CoA reductase activity GO:0080019 IBA
    alcohol-forming long-chain fatty acyl-CoA reductase activity GO:0102965 IDA
Biological Process
    ether lipid biosynthetic process GO:0008611 IDA
    ether lipid biosynthetic process GO:0008611 IMP
    wax biosynthetic process GO:0010025 ISS
    wax biosynthetic process GO:0010025 TAS
    long-chain fatty-acyl-CoA metabolic process GO:0035336 IBA
    long-chain fatty-acyl-CoA metabolic process GO:0035336 IDA
    glycerophospholipid biosynthetic process GO:0046474 IDA
Subcellular Localization
    peroxisome GO:0005777 IBA
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 HDA
    peroxisomal membrane GO:0005778 IDA
    peroxisomal membrane GO:0005778 TAS
 Experiment description of studies that identified FAR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FAR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HECTD1 25831
Affinity Capture-MS Homo sapiens
2 ATXN1 6310
Two-hybrid Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 SPRTN  
Affinity Capture-MS Homo sapiens
5 FBXL6  
Affinity Capture-MS Homo sapiens
6 KIF14 9928
Affinity Capture-MS Homo sapiens
7 SLC2A4  
Affinity Capture-MS Homo sapiens
8 ATG9A 79065
Proximity Label-MS Homo sapiens
9 IQCB1  
Affinity Capture-MS Homo sapiens
10 TPTE  
Affinity Capture-MS Homo sapiens
11 CUL5 8065
Affinity Capture-MS Homo sapiens
12 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EGFR 1956
Affinity Capture-MS Homo sapiens
14 CTDP1 9150
Affinity Capture-MS Homo sapiens
15 KLRD1  
Affinity Capture-MS Homo sapiens
16 PARK2  
Affinity Capture-MS Homo sapiens
17 DNAJC25 548645
Affinity Capture-MS Homo sapiens
18 DDX58 23586
Affinity Capture-RNA Homo sapiens
19 RIPK4  
Affinity Capture-MS Homo sapiens
20 AURKB 9212
Affinity Capture-MS Homo sapiens
21 DNAJB8  
Affinity Capture-MS Homo sapiens
22 CAPZB 832
Affinity Capture-MS Homo sapiens
23 MAPK6  
Affinity Capture-MS Homo sapiens
24 TBC1D32 221322
Proximity Label-MS Homo sapiens
25 CHMP4B 128866
Affinity Capture-MS Homo sapiens
26 DNAJA1 3301
Affinity Capture-MS Homo sapiens
27 PEX14 5195
Co-purification Homo sapiens
28 DNAJC16  
Affinity Capture-MS Homo sapiens
29 TRIM66  
Affinity Capture-MS Homo sapiens
30 CUL7 9820
Affinity Capture-MS Homo sapiens
31 C9orf72  
Affinity Capture-MS Homo sapiens
32 Rpl35 66489
Affinity Capture-MS Mus musculus
33 KLF15  
Affinity Capture-MS Homo sapiens
34 PEX3 8504
Proximity Label-MS Homo sapiens
35 AKAP1 8165
Proximity Label-MS Homo sapiens
36 HUWE1 10075
Affinity Capture-MS Homo sapiens
37 CYLD  
Affinity Capture-MS Homo sapiens
38 C20orf24  
Affinity Capture-MS Homo sapiens
39 CCDC8  
Affinity Capture-MS Homo sapiens
40 CD274 29126
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAR1 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Wax and plasmalogen biosynthesis TAS Reactome
Wax biosynthesis TAS Reactome





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