Gene description for PEX3
Gene name peroxisomal biogenesis factor 3
Gene symbol PEX3
Other names/aliases PBD10A
TRG18
Species Homo sapiens
 Database cross references - PEX3
ExoCarta ExoCarta_8504
Entrez Gene 8504
HGNC 8858
MIM 603164
UniProt P56589  
 PEX3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PEX3
Molecular Function
    lipid binding GO:0008289 IDA
    protein dimerization activity GO:0046983 IDA
    amino acid transmembrane transporter activity GO:0015171 IBA
    protein binding GO:0005515 IPI
Biological Process
    peroxisome membrane biogenesis GO:0016557 IEA
    amino acid transmembrane transport GO:0003333 IBA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    transmembrane transport GO:0055085 TAS
    positive regulation of defense response to virus by host GO:0002230 IMP
    peroxisome organization GO:0007031 IMP
    protein import into peroxisome membrane GO:0045046 IMP
Subcellular Localization
    cytosol GO:0005829 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    integral component of peroxisomal membrane GO:0005779 IDA
    protein complex GO:0043234 IDA
    membrane GO:0016020 IDA
    endoplasmic reticulum GO:0005783 IDA
    protein-lipid complex GO:0032994 IDA
    nucleoplasm GO:0005654 IDA
    peroxisomal membrane GO:0005778 TAS
    peroxisome GO:0005777 IMP
 Experiment description of studies that identified PEX3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PEX3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PEX19  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PEX3 is involved
PathwayEvidenceSource
ABCA transporters in lipid homeostasis TAS Reactome





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