Gene description for MARC2
Gene name mitochondrial amidoxime reducing component 2
Gene symbol MARC2
Other names/aliases MOSC2
Species Homo sapiens
 Database cross references - MARC2
ExoCarta ExoCarta_54996
Vesiclepedia VP_54996
Entrez Gene 54996
HGNC 26064
MIM 614127
UniProt Q969Z3  
 MARC2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MARC2
Molecular Function
    nitrate reductase activity GO:0008940 IBA
    nitrate reductase activity GO:0008940 IDA
    oxidoreductase activity, acting on other nitrogenous compounds as donors GO:0016661 IMP
    molybdenum ion binding GO:0030151 IBA
    molybdenum ion binding GO:0030151 IDA
    pyridoxal phosphate binding GO:0030170 IEA
    molybdopterin cofactor binding GO:0043546 IBA
    molybdopterin cofactor binding GO:0043546 IDA
    nitrite reductase activity GO:0098809 IDA
Biological Process
    nitric oxide biosynthetic process GO:0006809 IDA
    nitrate metabolic process GO:0042126 IBA
    nitrate metabolic process GO:0042126 IDA
    detoxification of nitrogen compound GO:0051410 NAS
    cellular detoxification of nitrogen compound GO:0070458 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISS
    mitochondrial outer membrane GO:0005741 TAS
    peroxisome GO:0005777 IEA
 Experiment description of studies that identified MARC2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MARC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 FTL 2512
Affinity Capture-MS Homo sapiens
3 SNX27 81609
Affinity Capture-MS Homo sapiens
4 KCNA2  
Affinity Capture-MS Homo sapiens
5 AIFM1 9131
Proximity Label-MS Homo sapiens
6 TDRKH  
Affinity Capture-MS Homo sapiens
7 MARCKS 4082
Proximity Label-MS Homo sapiens
8 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PXMP2  
Proximity Label-MS Homo sapiens
10 RP2 6102
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CRELD1 78987
Affinity Capture-MS Homo sapiens
12 SAAL1 113174
Affinity Capture-MS Homo sapiens
13 PDE2A  
Affinity Capture-MS Homo sapiens
14 PPP4R1L  
Affinity Capture-MS Homo sapiens
15 EXD2  
Proximity Label-MS Homo sapiens
16 PEX14 5195
Proximity Label-MS Homo sapiens
17 SLC31A1 1317
Affinity Capture-MS Homo sapiens
18 PEX3 8504
Proximity Label-MS Homo sapiens
19 AKAP1 8165
Proximity Label-MS Homo sapiens
20 SYBU  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ACBD5 91452
Proximity Label-MS Homo sapiens
22 MTHFD1L 25902
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MARC2 is involved
PathwayEvidenceSource
Biological oxidations TAS Reactome
Metabolism TAS Reactome
Phase I - Functionalization of compounds TAS Reactome





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