ExoCarta: Gene summary

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Gene description for CRELD1
Gene name	cysteine-rich with EGF-like domains 1
Gene symbol	CRELD1
Other names/aliases	AVSD2 CIRRIN
Species	Homo sapiens
Database cross references - CRELD1
ExoCarta	ExoCarta_78987
Vesiclepedia	VP_78987
Entrez Gene	78987
HGNC	14630
MIM	607170
UniProt	Q96HD1
CRELD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for CRELD1

Molecular Function
	protein disulfide isomerase activity	GO:0003756	IEA
	extracellular matrix structural constituent	GO:0005201	RCA
	calcium ion binding	GO:0005509	IEA
	protein binding	GO:0005515	IPI
Biological Process
	endocardial cushion development	GO:0003197	TAS
	cardiac septum development	GO:0003279	TAS
Subcellular Localization
	membrane	GO:0016020	IEA
	collagen-containing extracellular matrix	GO:0062023	HDA
	glutamatergic synapse	GO:0098978	IEA

Experiment description of studies that identified CRELD1 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for CRELD1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

DPY19L1

23333

Affinity Capture-MS

Homo sapiens

POMT2

Affinity Capture-MS

Homo sapiens

KDELR3

11015

Affinity Capture-MS

Homo sapiens

SLC16A13

201232

Affinity Capture-MS

Homo sapiens

DERL2

51009

Affinity Capture-MS

Homo sapiens

EEF1G

1937

Two-hybrid

Homo sapiens

ORMDL3

94103

Affinity Capture-MS

Homo sapiens

ATP13A2

Affinity Capture-MS

Homo sapiens

COPS6

10980

Two-hybrid

Homo sapiens

HTR3A

Affinity Capture-MS

Homo sapiens

ALG12

Affinity Capture-MS

Homo sapiens

GDF9

2661

Two-hybrid

Homo sapiens

ANKRD9

Affinity Capture-MS

Homo sapiens

NDUFB5

4711

Affinity Capture-MS

Homo sapiens

TMEM186

Affinity Capture-MS

Homo sapiens

GPR114

Affinity Capture-MS

Homo sapiens

NDUFB6

4712

Affinity Capture-MS

Homo sapiens

ST7

Affinity Capture-MS

Homo sapiens

SETDB1

Two-hybrid

Homo sapiens

TRIM68

55128

Affinity Capture-MS

Homo sapiens

SLC16A10

117247

Affinity Capture-MS

Homo sapiens

SPG7

Affinity Capture-MS

Homo sapiens

ABCD1

215

Affinity Capture-MS

Homo sapiens

INTS8

Affinity Capture-MS

Homo sapiens

NDUFB9

4715

Affinity Capture-MS

Homo sapiens

ALG10

Affinity Capture-MS

Homo sapiens

ALG3

10195

Affinity Capture-MS

Homo sapiens

MCU

90550

Affinity Capture-MS

Homo sapiens

ZNF408

Two-hybrid

Homo sapiens

NDUFB8

4714

Affinity Capture-MS

Homo sapiens

NDUFA7

4701

Affinity Capture-MS

Homo sapiens

GABBR1

Affinity Capture-MS

Homo sapiens

ABCC3

8714

Affinity Capture-MS

Homo sapiens

ABCD3

5825

Affinity Capture-MS

Homo sapiens

RER1

11079

Affinity Capture-MS

Homo sapiens

SLC10A7

Affinity Capture-MS

Homo sapiens

SLC35B2

347734

Affinity Capture-MS

Homo sapiens

CES2

8824

Affinity Capture-MS

Homo sapiens

SLC30A5

64924

Affinity Capture-MS

Homo sapiens

ERMP1

79956

Affinity Capture-MS

Homo sapiens

SLC25A46

91137

Affinity Capture-MS

Homo sapiens

NDUFV3

4731

Affinity Capture-MS

Homo sapiens

BET1

10282

Affinity Capture-MS

Homo sapiens

BCS1L

617

Affinity Capture-MS

Homo sapiens

LMF2

91289

Affinity Capture-MS

Homo sapiens

SLC25A33

Affinity Capture-MS

Homo sapiens

TMEM201

199953

Affinity Capture-MS

Homo sapiens

CAMLG

819

Affinity Capture-MS

Homo sapiens

MTNR1B

Two-hybrid

Homo sapiens

POLA2

Two-hybrid

Homo sapiens

PXMP2

Affinity Capture-MS

Homo sapiens

TMEM120A

83862

Affinity Capture-MS

Homo sapiens

SCN9A

Affinity Capture-MS

Homo sapiens

NDUFS4

4724

Affinity Capture-MS

Homo sapiens

ATP8B2

57198

Affinity Capture-MS

Homo sapiens

COX15

1355

Affinity Capture-MS

Homo sapiens

BNIP1

662

Affinity Capture-MS

Homo sapiens

NDUFB7

4713

Affinity Capture-MS

Homo sapiens

SLC38A7

55238

Affinity Capture-MS

Homo sapiens

UGT8

Affinity Capture-MS

Homo sapiens

TMTC3

160418

Affinity Capture-MS

Homo sapiens

TLCD1

Affinity Capture-MS

Homo sapiens

KIAA2013

90231

Affinity Capture-MS

Homo sapiens

ND1

Affinity Capture-MS

Homo sapiens

LEMD2

221496

Affinity Capture-MS

Homo sapiens

SLC25A17

10478

Affinity Capture-MS

Homo sapiens

LETMD1

Affinity Capture-MS

Homo sapiens

P2RY12

64805

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TMEM56

Affinity Capture-MS

Homo sapiens

TMTC4

Affinity Capture-MS

Homo sapiens

UQCRH

7388

Affinity Capture-MS

Homo sapiens

ELOVL5

60481

Affinity Capture-MS

Homo sapiens

RMDN3

55177

Affinity Capture-MS

Homo sapiens

LRRC8A

56262

Affinity Capture-MS

Homo sapiens

MFSD12

Affinity Capture-MS

Homo sapiens

SPPL3

Affinity Capture-MS

Homo sapiens

ATP9A

10079

Affinity Capture-MS

Homo sapiens

CYP26B1

Affinity Capture-MS

Homo sapiens

SGPL1

8879

Affinity Capture-MS

Homo sapiens

GPAA1

8733

Affinity Capture-MS

Homo sapiens

LMBRD2

92255

Affinity Capture-MS

Homo sapiens

TMEM39B

Affinity Capture-MS

Homo sapiens

FITM2

Affinity Capture-MS

Homo sapiens

EIF6

3692

Two-hybrid

Homo sapiens

ND5

4540

Affinity Capture-MS

Homo sapiens

FZD10

Affinity Capture-MS

Homo sapiens

TMEM223

Affinity Capture-MS

Homo sapiens

GOLT1B

51026

Affinity Capture-MS

Homo sapiens

CUL3

8452

Affinity Capture-MS

Homo sapiens

GPD2

2820

Affinity Capture-MS

Homo sapiens

RMND1

55005

Affinity Capture-MS

Homo sapiens

MAP3K1

4214

Biochemical Activity

Homo sapiens

AAAS

8086

Affinity Capture-MS

Homo sapiens

LPCAT3

10162

Affinity Capture-MS

Homo sapiens

LPAR1

1902

Affinity Capture-MS

Homo sapiens

SGPP1

81537

Affinity Capture-MS

Homo sapiens

ORMDL1

94101

Affinity Capture-MS

Homo sapiens

TM9SF3

56889

Affinity Capture-MS

Homo sapiens

CD27

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

100

ATP5J2

9551

Two-hybrid

Homo sapiens

101

SOAT1

6646

Affinity Capture-MS

Homo sapiens

102

ALG8

Affinity Capture-MS

Homo sapiens

103

HTR2C

Two-hybrid

Homo sapiens

104

NDUFB3

4709

Affinity Capture-MS

Homo sapiens

105

HIBADH

11112

Affinity Capture-MS

Homo sapiens

106

DOLK

22845

Affinity Capture-MS

Homo sapiens

107

SLC30A7

148867

Affinity Capture-MS

Homo sapiens

108

KAT5

Two-hybrid

Homo sapiens

109

CERS6

Affinity Capture-MS

Homo sapiens

110

CACNG1

Affinity Capture-MS

Homo sapiens

111

SLC22A4

6583

Affinity Capture-MS

Homo sapiens

112

TMEM104

54868

Affinity Capture-MS

Homo sapiens

113

NDUFC2

4718

Affinity Capture-MS

Homo sapiens

114

MARC2

54996

Affinity Capture-MS

Homo sapiens

115

PARP16

54956

Affinity Capture-MS

Homo sapiens

116

SLC22A18

5002

Affinity Capture-MS

Homo sapiens

117

DRD2

Two-hybrid

Homo sapiens

118

ORMDL2

29095

Affinity Capture-MS

Homo sapiens

119

SLC4A2

6522

Affinity Capture-MS

Homo sapiens

120

FLVCR1

28982

Affinity Capture-MS

Homo sapiens

121

MBOAT7

79143

Affinity Capture-MS

Homo sapiens

122

MANEA

79694

Affinity Capture-MS

Homo sapiens

123

SUN1

23353

Affinity Capture-MS

Homo sapiens

124

PIGW

Affinity Capture-MS

Homo sapiens

125

PEX11B

8799

Affinity Capture-MS

Homo sapiens

126

GPR89A

Affinity Capture-MS

Homo sapiens

127

TMEM57

Affinity Capture-MS

Homo sapiens

128

CDS1

Affinity Capture-MS

Homo sapiens

129

PIEZO1

9780

Affinity Capture-MS

Homo sapiens

130

TMEM214

54867

Affinity Capture-MS

Homo sapiens

131

TMEM120B

Affinity Capture-MS

Homo sapiens

132

EMC4

51234

Affinity Capture-MS

Homo sapiens

133

ABCC4

10257

Affinity Capture-MS

Homo sapiens

134

TMEM14C

51522

Affinity Capture-MS

Homo sapiens

135

NDUFA12

55967

Affinity Capture-MS

Homo sapiens

136

PIGU

128869

Affinity Capture-MS

Homo sapiens

137

SLC35F6

54978

Affinity Capture-MS

Homo sapiens

138

PTGER3

Affinity Capture-MS

Homo sapiens

139

PTN

Two-hybrid

Homo sapiens

140

ALG6

Affinity Capture-MS

Homo sapiens

141

SPCS1

28972

Affinity Capture-MS

Homo sapiens

142

NDC1

55706

Affinity Capture-MS

Homo sapiens

143

SPPL2B

56928

Affinity Capture-MS

Homo sapiens

144

TMEM38B

Affinity Capture-MS

Homo sapiens

145

HSDL1

83693

Affinity Capture-MS

Homo sapiens

146

ALG10B

Affinity Capture-MS

Homo sapiens

147

CISD2

493856

Affinity Capture-MS

Homo sapiens

148

PEX5

5830

Affinity Capture-MS

Homo sapiens

149

RFT1

91869

Affinity Capture-MS

Homo sapiens

150

TUBB8

347688

Affinity Capture-MS

Homo sapiens

151

ND4

4538

Affinity Capture-MS

Homo sapiens

152

NDUFS6

Affinity Capture-MS

Homo sapiens

153

SLC5A3

6526

Affinity Capture-MS

Homo sapiens

154

FAM210B

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which CRELD1 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here