Gene description for SGPL1
Gene name sphingosine-1-phosphate lyase 1
Gene symbol SGPL1
Other names/aliases S1PL
SPL
Species Homo sapiens
 Database cross references - SGPL1
ExoCarta ExoCarta_8879
Entrez Gene 8879
HGNC 10817
MIM 603729
UniProt O95470  
 SGPL1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SGPL1
Molecular Function
    carboxy-lyase activity GO:0016831 IEA
    protein binding GO:0005515 IPI
    pyridoxal phosphate binding GO:0030170 IEA
    sphinganine-1-phosphate aldolase activity GO:0008117 NAS
Biological Process
    palate development GO:0060021 IEA
    spermatogenesis GO:0007283 IEA
    sphingolipid biosynthetic process GO:0030148 TAS
    sphingolipid catabolic process GO:0030149 NAS
    skeletal system morphogenesis GO:0048705 IEA
    fatty acid metabolic process GO:0006631 IDA
    fibroblast migration GO:0010761 IEA
    luteinization GO:0001553 IEA
    small molecule metabolic process GO:0044281 TAS
    sphingolipid metabolic process GO:0006665 TAS
    ceramide metabolic process GO:0006672 IDA
    androgen metabolic process GO:0008209 IEA
    kidney development GO:0001822 IEA
    estrogen metabolic process GO:0008210 IEA
    post-embryonic development GO:0009791 IEA
    hemopoiesis GO:0030097 IEA
    regulation of multicellular organism growth GO:0040014 IEA
    face morphogenesis GO:0060325 IEA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    apoptotic signaling pathway GO:0097190 IDA
    vasculogenesis GO:0001570 IEA
    Leydig cell differentiation GO:0033327 IEA
Subcellular Localization
    integral component of endoplasmic reticulum membrane GO:0030176 NAS
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified SGPL1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SGPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SGPL1 is involved
PathwayEvidenceSource
Sphingolipid de novo biosynthesis TAS Reactome





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