Gene description for IL17RA
Gene name interleukin 17 receptor A
Gene symbol IL17RA
Other names/aliases CANDF5
CD217
CDw217
IL-17RA
IL17R
hIL-17R
Species Homo sapiens
 Database cross references - IL17RA
ExoCarta ExoCarta_23765
Vesiclepedia VP_23765
Entrez Gene 23765
HGNC 5985
MIM 605461
UniProt Q96F46  
 IL17RA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IL17RA
Molecular Function
    signaling receptor binding GO:0005102 IEA
    protein binding GO:0005515 IPI
    interleukin-17 receptor activity GO:0030368 IBA
    interleukin-17 receptor activity GO:0030368 IDA
    interleukin-17 receptor activity GO:0030368 NAS
Biological Process
    inflammatory response GO:0006954 IEA
    cell surface receptor signaling pathway GO:0007166 NAS
    response to virus GO:0009615 IDA
    protein catabolic process GO:0030163 IEA
    positive regulation of interleukin-13 production GO:0032736 IEA
    positive regulation of interleukin-23 production GO:0032747 IDA
    positive regulation of interleukin-5 production GO:0032754 IEA
    positive regulation of interleukin-6 production GO:0032755 IMP
    interleukin-17A-mediated signaling pathway GO:0038173 IDA
    innate immune response GO:0045087 IEA
    positive regulation of inflammatory response GO:0050729 IDA
    defense response to fungus GO:0050832 IEA
    granulocyte chemotaxis GO:0071621 IEA
    fibroblast activation GO:0072537 IDA
    T-helper 17 type immune response GO:0072538 IEA
    interleukin-17-mediated signaling pathway GO:0097400 IDA
    interleukin-17-mediated signaling pathway GO:0097400 IMP
    positive regulation of cytokine production involved in inflammatory response GO:1900017 IDA
    positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified IL17RA in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IL17RA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C2CD2L 9854
Affinity Capture-MS Homo sapiens
2 C15orf39  
Affinity Capture-MS Homo sapiens
3 FAM208A  
Affinity Capture-MS Homo sapiens
4 MCM8 84515
Affinity Capture-MS Homo sapiens
5 LILRA5  
Affinity Capture-MS Homo sapiens
6 KLK15  
Affinity Capture-MS Homo sapiens
7 KLK8 11202
Affinity Capture-MS Homo sapiens
8 LCN6  
Affinity Capture-MS Homo sapiens
9 DAG1 1605
Affinity Capture-MS Homo sapiens
10 CFC1  
Affinity Capture-MS Homo sapiens
11 MFAP4 4239
Affinity Capture-MS Homo sapiens
12 FAM189B  
Affinity Capture-MS Homo sapiens
13 IL22RA2  
Affinity Capture-MS Homo sapiens
14 IGFBP4 3487
Affinity Capture-MS Homo sapiens
15 SLURP1  
Affinity Capture-MS Homo sapiens
16 EIF4E2  
Affinity Capture-MS Homo sapiens
17 KLK2  
Affinity Capture-MS Homo sapiens
18 RPS6KA3 6197
Affinity Capture-MS Homo sapiens
19 HDAC3 8841
Affinity Capture-MS Homo sapiens
20 NCOR1  
Affinity Capture-MS Homo sapiens
21 BTLA  
Affinity Capture-MS Homo sapiens
22 BTRC 8945
Affinity Capture-MS Homo sapiens
23 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
24 VRK2 7444
Affinity Capture-MS Homo sapiens
25 ESPL1  
Affinity Capture-MS Homo sapiens
26 PLCH1  
Affinity Capture-MS Homo sapiens
27 OSBP 5007
Affinity Capture-MS Homo sapiens
28 NCR3  
Affinity Capture-MS Homo sapiens
29 ENPP7 339221
Affinity Capture-MS Homo sapiens
30 PNPLA6 10908
Affinity Capture-MS Homo sapiens
31 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
32 USP33  
Affinity Capture-MS Homo sapiens
33 BCOR  
Affinity Capture-MS Homo sapiens
34 C5orf34  
Affinity Capture-MS Homo sapiens
35 SYK 6850
Affinity Capture-Western Homo sapiens
36 GTSE1 51512
Affinity Capture-MS Homo sapiens
37 RPS6KA2  
Affinity Capture-MS Homo sapiens
38 PKN3 29941
Affinity Capture-MS Homo sapiens
39 ELSPBP1  
Affinity Capture-MS Homo sapiens
40 CCDC88A 55704
Affinity Capture-MS Homo sapiens
41 ICE2  
Affinity Capture-MS Homo sapiens
42 TMEM87A 25963
Affinity Capture-MS Homo sapiens
43 LRIF1  
Affinity Capture-MS Homo sapiens
44 DNASE2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 BRIP1  
Affinity Capture-MS Homo sapiens
46 FCN3 8547
Affinity Capture-MS Homo sapiens
47 SIMC1  
Affinity Capture-MS Homo sapiens
48 PPIP5K2 23262
Affinity Capture-MS Homo sapiens
49 HTT 3064
Affinity Capture-MS Homo sapiens
50 BCAS3 54828
Affinity Capture-MS Homo sapiens
51 IDS  
Affinity Capture-MS Homo sapiens
52 ANKHD1 54882
Affinity Capture-MS Homo sapiens
53 SREBF2 6721
Affinity Capture-MS Homo sapiens
54 SDF2L1 23753
Affinity Capture-MS Homo sapiens
55 TYK2 7297
Affinity Capture-MS Homo sapiens
56 CRISP2  
Affinity Capture-MS Homo sapiens
57 SIRPD  
Affinity Capture-MS Homo sapiens
58 LYPD1  
Affinity Capture-MS Homo sapiens
59 GSG2  
Affinity Capture-MS Homo sapiens
60 STX5 6811
Affinity Capture-MS Homo sapiens
61 CST8  
Affinity Capture-MS Homo sapiens
62 LYPD4  
Affinity Capture-MS Homo sapiens
63 PDGFRA 5156
Affinity Capture-MS Homo sapiens
64 ZPBP2  
Affinity Capture-MS Homo sapiens
65 RPS6KA1 6195
Affinity Capture-MS Homo sapiens
66 LY86  
Affinity Capture-MS Homo sapiens
67 LY6H  
Affinity Capture-MS Homo sapiens
68 ZNF644  
Affinity Capture-MS Homo sapiens
69 GPIHBP1  
Affinity Capture-MS Homo sapiens
70 DDX11L8  
Affinity Capture-MS Homo sapiens
71 EPDR1 54749
Affinity Capture-MS Homo sapiens
72 SGPL1 8879
Affinity Capture-MS Homo sapiens
73 MAP7 9053
Affinity Capture-MS Homo sapiens
74 PRG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CANX 821
Affinity Capture-MS Homo sapiens
76 NR3C1 2908
Affinity Capture-MS Homo sapiens
77 SMG8 55181
Affinity Capture-MS Homo sapiens
78 CMA1  
Affinity Capture-MS Homo sapiens
79 GGH 8836
Affinity Capture-MS Homo sapiens
80 IQCB1  
Affinity Capture-MS Homo sapiens
81 ACAD11 84129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 WDR25  
Affinity Capture-MS Homo sapiens
83 PRG2  
Affinity Capture-MS Homo sapiens
84 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 PI15  
Affinity Capture-MS Homo sapiens
86 RICTOR 253260
Affinity Capture-MS Homo sapiens
87 CBLN4  
Affinity Capture-MS Homo sapiens
88 USP54 159195
Affinity Capture-MS Homo sapiens
89 LYZL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 FRMD5 84978
Affinity Capture-MS Homo sapiens
91 TTF2 8458
Affinity Capture-MS Homo sapiens
92 MAP3K7  
Affinity Capture-Western Homo sapiens
93 TBCD 6904
Affinity Capture-MS Homo sapiens
94 PLEKHA5 54477
Affinity Capture-MS Homo sapiens
95 TUBA4A 7277
Affinity Capture-MS Homo sapiens
96 HAUS5 23354
Affinity Capture-MS Homo sapiens
97 RETSAT 54884
Affinity Capture-MS Homo sapiens
98 KIAA0586  
Affinity Capture-MS Homo sapiens
99 TAOK2 9344
Affinity Capture-MS Homo sapiens
100 CRLF1 9244
Affinity Capture-MS Homo sapiens
101 KLK3  
Affinity Capture-MS Homo sapiens
102 FBXO2 26232
Affinity Capture-MS Homo sapiens
103 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
104 ZNHIT6 54680
Affinity Capture-MS Homo sapiens
105 C14orf80  
Affinity Capture-MS Homo sapiens
106 TBL1X 6907
Affinity Capture-MS Homo sapiens
107 GXYLT1 283464
Affinity Capture-MS Homo sapiens
108 KIAA1671  
Affinity Capture-MS Homo sapiens
109 NXPH3  
Affinity Capture-MS Homo sapiens
110 EDN3  
Affinity Capture-MS Homo sapiens
111 ISLR 3671
Affinity Capture-MS Homo sapiens
112 SIK2  
Affinity Capture-MS Homo sapiens
113 IL5RA  
Affinity Capture-MS Homo sapiens
114 CBWD1 55871
Affinity Capture-MS Homo sapiens
115 OSBPL8 114882
Affinity Capture-MS Homo sapiens
116 MAP7D2 256714
Affinity Capture-MS Homo sapiens
117 TMX2 51075
Affinity Capture-MS Homo sapiens
118 LYZL2  
Affinity Capture-MS Homo sapiens
119 ADAM30 11085
Affinity Capture-MS Homo sapiens
120 HMGCR  
Affinity Capture-MS Homo sapiens
121 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
122 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
123 LGI1  
Affinity Capture-MS Homo sapiens
124 IL17A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 C1orf43 25912
Affinity Capture-MS Homo sapiens
126 TRPS1  
Affinity Capture-MS Homo sapiens
127 MKS1 54903
Affinity Capture-MS Homo sapiens
128 PIGA  
Affinity Capture-MS Homo sapiens
129 IQGAP3 128239
Affinity Capture-MS Homo sapiens
130 TYW1  
Affinity Capture-MS Homo sapiens
131 EPHX1 2052
Affinity Capture-MS Homo sapiens
132 DYNC2H1 79659
Affinity Capture-MS Homo sapiens
133 PDE3B  
Affinity Capture-MS Homo sapiens
134 OS9 10956
Affinity Capture-MS Homo sapiens
135 SLAMF1 6504
Affinity Capture-MS Homo sapiens
136 TUBB1 81027
Affinity Capture-MS Homo sapiens
137 YEATS2  
Affinity Capture-MS Homo sapiens
138 DDX11 1663
Affinity Capture-MS Homo sapiens
139 ADAMTS12 81792
Affinity Capture-MS Homo sapiens
140 SUSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 ZBTB33  
Affinity Capture-MS Homo sapiens
142 KCNT2  
Affinity Capture-MS Homo sapiens
143 ALPP 250
Affinity Capture-MS Homo sapiens
144 WISP3  
Affinity Capture-MS Homo sapiens
145 PODN 127435
Affinity Capture-MS Homo sapiens
146 ALG11  
Affinity Capture-MS Homo sapiens
147 ZNF318 24149
Affinity Capture-MS Homo sapiens
148 ANKLE2 23141
Affinity Capture-MS Homo sapiens
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