Gene description for PPIP5K2
Gene name diphosphoinositol pentakisphosphate kinase 2
Gene symbol PPIP5K2
Other names/aliases HISPPD1
IP7K2
VIP2
Species Homo sapiens
 Database cross references - PPIP5K2
ExoCarta ExoCarta_23262
Entrez Gene 23262
HGNC 29035
MIM 611648
UniProt O43314  
 PPIP5K2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PPIP5K2
Molecular Function
    inositol hexakisphosphate 5-kinase activity GO:0000832 ISS
    diphosphoinositol-pentakisphosphate kinase activity GO:0033857 ISS
    acid phosphatase activity GO:0003993 IEA
    inositol hexakisphosphate 1-kinase activity GO:0052723 IEA
    inositol-1,3,4,5,6-pentakisphosphate kinase activity GO:0000827 ISS
    ATP binding GO:0005524 IEA
    inositol hexakisphosphate 3-kinase activity GO:0052724 IEA
Biological Process
    inositol phosphate metabolic process GO:0043647 TAS
    dephosphorylation GO:0016311 IEA
    small molecule metabolic process GO:0044281 TAS
    inositol metabolic process GO:0006020 ISS
    phosphorylation GO:0016310 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PPIP5K2 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPIP5K2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPIP5K2 is involved
PathwayEvidenceSource
Synthesis of pyrophosphates in the cytosol TAS Reactome





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