Gene description for BAG2
Gene name BCL2-associated athanogene 2
Gene symbol BAG2
Other names/aliases BAG-2
dJ417I1.2
Species Homo sapiens
 Database cross references - BAG2
ExoCarta ExoCarta_9532
Entrez Gene 9532
HGNC 938
MIM 603882
UniProt O95816  
 BAG2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for BAG2
Molecular Function
    identical protein binding GO:0042802 IPI
    chaperone binding GO:0051087 IEA
    protein binding GO:0005515 IPI
Biological Process
    protein metabolic process GO:0019538 IDA
    protein folding GO:0006457 TAS
    cellular response to heat GO:0034605 TAS
    regulation of cellular response to heat GO:1900034 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified BAG2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BAG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMC4 5704
Affinity Capture-MS Homo sapiens
2 HSPA8 3312
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 MLF2 8079
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BAG2 is involved
PathwayEvidenceSource
Regulation of HSF1-mediated heat shock response TAS Reactome





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