Gene description for PPP2R2D
Gene name protein phosphatase 2, regulatory subunit B, delta
Gene symbol PPP2R2D
Other names/aliases MDS026
Species Homo sapiens
 Database cross references - PPP2R2D
ExoCarta ExoCarta_55844
Vesiclepedia VP_55844
Entrez Gene 55844
HGNC 23732
MIM 613992
UniProt Q66LE6  
 PPP2R2D identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for PPP2R2D
Molecular Function
    protein binding GO:0005515 IPI
    protein phosphatase regulator activity GO:0019888 IBA
    protein phosphatase regulator activity GO:0019888 ISS
    enzyme-substrate adaptor activity GO:0140767 ISS
Biological Process
    mitotic cell cycle GO:0000278 ISS
    exit from mitosis GO:0010458 ISS
    cell division GO:0051301 IEA
    regulation of chromosome segregation GO:0051983 ISS
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IBA
    protein phosphatase type 2A complex GO:0000159 ISS
    cytosol GO:0005829 IBA
 Experiment description of studies that identified PPP2R2D in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2R2D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ENSA 2029
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
2 DPPA3  
Affinity Capture-MS Homo sapiens
3 ANKLE2 23141
Affinity Capture-MS Homo sapiens
4 PPP2R5D 5528
Co-fractionation Homo sapiens
5 YEATS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZNF645  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RIN3  
Affinity Capture-MS Homo sapiens
8 GTF2IRD1  
Affinity Capture-MS Homo sapiens
9 FOXD3  
Affinity Capture-MS Homo sapiens
10 DAPK1 1612
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
11 WNT7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 EN1  
Affinity Capture-MS Homo sapiens
13 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
14 CCT6B 10693
Affinity Capture-MS Homo sapiens
15 GRB10 2887
Affinity Capture-MS Homo sapiens
16 CCDC9  
Affinity Capture-MS Homo sapiens
17 RASA3 22821
Affinity Capture-MS Homo sapiens
18 ZNF414  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 IER5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
21 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 LYG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 YWHAZ 7534
Cross-Linking-MS (XL-MS) Homo sapiens
24 BTN2A1 11120
Affinity Capture-MS Homo sapiens
25 CAPN12  
Affinity Capture-MS Homo sapiens
26 ZBTB21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MCM2 4171
Affinity Capture-MS Homo sapiens
28 ATXN2L 11273
Affinity Capture-MS Homo sapiens
29 TRIM35 23087
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CLEC18A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CCAR2 57805
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
32 IQGAP1 8826
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
34 PIF1  
Affinity Capture-MS Homo sapiens
35 BCL2L14  
Affinity Capture-MS Homo sapiens
36 PRELP 5549
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 FOXD4L6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TULP3 7289
Affinity Capture-MS Homo sapiens
39 SARNP 84324
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NDUFAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 FOXD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CCDC130  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SCGB1D2  
Affinity Capture-MS Homo sapiens
44 RPS11 6205
Affinity Capture-MS Homo sapiens
45 SGOL2 151246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 C19orf45  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SERTAD2 9792
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
49 ZNF550  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CDK16 5127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TCP1 6950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 FOXC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 ATF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PINX1  
Affinity Capture-MS Homo sapiens
55 IGFBP5 3488
Affinity Capture-MS Homo sapiens
56 PARK2  
Affinity Capture-MS Homo sapiens
57 FAM122A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 TCEAL1  
Affinity Capture-MS Homo sapiens
59 BEX4  
Affinity Capture-MS Homo sapiens
60 FAM9C  
Affinity Capture-MS Homo sapiens
61 RBM7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SNAI2  
Affinity Capture-MS Homo sapiens
63 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
64 ATF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 FOXD4L1  
Affinity Capture-MS Homo sapiens
66 WDR61 80349
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
67 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 SERTAD1  
Affinity Capture-MS Homo sapiens
69 NCAPD3 23310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CDKN3 1033
Affinity Capture-MS Homo sapiens
71 FOXC2  
Affinity Capture-MS Homo sapiens
72 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 KIAA1522 57648
Affinity Capture-MS Homo sapiens
74 PLEKHO2 80301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CRY2  
Affinity Capture-MS Homo sapiens
76 GPC5 2262
Affinity Capture-MS Homo sapiens
77 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 TRMT2A 27037
Affinity Capture-MS Homo sapiens
79 HDAC5 10014
Affinity Capture-MS Homo sapiens
80 FOXS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
82 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 FOXF2  
Affinity Capture-MS Homo sapiens
84 COX5B 1329
Affinity Capture-MS Homo sapiens
85 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 ACLY 47
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
87 WNT3A 89780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 BAG2 9532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 ZNF232  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
91 GYS1 2997
Affinity Capture-MS Homo sapiens
92 CRYAA 1409
Affinity Capture-MS Homo sapiens
93 HOXB2  
Proximity Label-MS Homo sapiens
94 UNG  
Affinity Capture-MS Homo sapiens
95 TFPT  
Affinity Capture-MS Homo sapiens
96 BMP15 9210
Affinity Capture-MS Homo sapiens
97 JUN 3725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 DMAP1 55929
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 PRR3  
Affinity Capture-MS Homo sapiens
100 FAM122B  
Affinity Capture-MS Homo sapiens
101 ZNF213  
Affinity Capture-MS Homo sapiens
102 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 CCT8 10694
Affinity Capture-MS Homo sapiens
104 GSTK1 373156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 PTPDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 PHF5A 84844
Affinity Capture-MS Homo sapiens
107 SKIV2L2 23517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
108 THEG  
Affinity Capture-MS Homo sapiens
109 PPP2R5A 5525
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 SERTAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 ZNF263  
Affinity Capture-MS Homo sapiens
113 PPME1 51400
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
115 PPP4C 5531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 ZNF785  
Affinity Capture-MS Homo sapiens
117 CDCA4 55038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
118 RAB11FIP5 26056
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 TTC33  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
120 VIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 C5orf24 134553
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 WNT10B 7480
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 NMB  
Affinity Capture-MS Homo sapiens
125 IER2 9592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 PTTG1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
127 PPP2R2C 5522
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 MLH1 4292
Affinity Capture-MS Homo sapiens
129 RFWD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
131 CREB5 9586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 ATAD3A 55210
Affinity Capture-MS Homo sapiens
133 PTPN5  
Affinity Capture-MS Homo sapiens
134 HOXC8  
Affinity Capture-MS Homo sapiens
135 C1orf87  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 ATAD3B 83858
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 SKA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 AAMP 14
Affinity Capture-MS Homo sapiens
139 AIFM2 84883
Affinity Capture-MS Homo sapiens
140 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
141 ECSIT 51295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPP2R2D is involved
PathwayEvidenceSource
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
M Phase IEA Reactome
MASTL Facilitates Mitotic Progression IEA Reactome
Mitotic Prophase IEA Reactome





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