Gene description for MLH1
Gene name	mutL homolog 1
Gene symbol	MLH1
Other names/aliases	COCA2 FCC2 HNPCC HNPCC2 hMLH1
Species	Homo sapiens
Database cross references - MLH1
ExoCarta	ExoCarta_4292
Vesiclepedia	VP_4292
Entrez Gene	4292
HGNC	7127
MIM	120436
UniProt	P40692
MLH1 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723
Thymus	23844026

Gene ontology annotations for MLH1

Molecular Function     chromatin binding GO:0003682 IDA     single-stranded DNA binding GO:0003697 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP hydrolysis activity GO:0016887 IBA     enzyme binding GO:0019899 IPI     guanine/thymine mispair binding GO:0032137 IEA     MutSalpha complex binding GO:0032407 IDA     ATP-dependent DNA damage sensor activity GO:0140664 IEA Biological Process     nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 IEA     resolution of meiotic recombination intermediates GO:0000712 IEA     mismatch repair GO:0006298 IBA     mismatch repair GO:0006298 IGI     double-strand break repair via nonhomologous end joining GO:0006303 IEA     male meiosis chromosome segregation GO:0007060 IEA     homologous chromosome pairing at meiosis GO:0007129 IEA     spermatogenesis GO:0007283 IEA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA     response to bacterium GO:0009617 IEA     female meiosis chromosome segregation GO:0016321 IEA     somatic hypermutation of immunoglobulin genes GO:0016446 IBA     meiotic metaphase I homologous chromosome alignment GO:0043060 IEA     meiotic telomere clustering GO:0045141 IEA     isotype switching GO:0045190 IEA     negative regulation of mitotic recombination GO:0045950 IEA     positive regulation of isotype switching to IgA isotypes GO:0048298 IEA     positive regulation of isotype switching to IgG isotypes GO:0048304 IEA     oogenesis GO:0048477 IEA     meiotic spindle midzone assembly GO:0051257 IEA Subcellular Localization     synaptonemal complex GO:0000795 IEA     male germ cell nucleus GO:0001673 IEA     nucleus GO:0005634 IC     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     chromosome GO:0005694 ISS     chiasma GO:0005712 IEA     late recombination nodule GO:0005715 IEA     membrane GO:0016020 HDA     MutLalpha complex GO:0032389 IBA