Gene description for MLH1
Gene name	mutL homolog 1
Gene symbol	MLH1
Other names/aliases	COCA2 FCC2 HNPCC HNPCC2 hMLH1
Species	Homo sapiens
Database cross references - MLH1
ExoCarta	ExoCarta_4292
Entrez Gene	4292
HGNC	7127
MIM	120436
UniProt	P40692
MLH1 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723
Thymus	23844026

Gene ontology annotations for MLH1

Molecular Function     ATP binding GO:0005524 IEA     guanine/thymine mispair binding GO:0032137 IEA     protein binding GO:0005515 IPI     MutSalpha complex binding GO:0032407 IDA     single-stranded DNA binding GO:0003697 IDA     ATPase activity GO:0016887 IBA Biological Process     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA     somatic hypermutation of immunoglobulin genes GO:0016446 IBA     nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 IEA     mismatch repair GO:0006298 TAS     double-strand break repair via nonhomologous end joining GO:0006303 IEA     meiotic metaphase I plate congression GO:0043060 IEA     resolution of meiotic recombination intermediates GO:0000712 IEA     DNA repair GO:0006281 TAS     negative regulation of mitotic recombination GO:0045950 IEA     isotype switching GO:0045190 IEA     spermatogenesis GO:0007283 IEA     oogenesis GO:0048477 IEA     meiotic spindle midzone assembly GO:0051257 IEA     synapsis GO:0007129 IEA     male meiosis chromosome segregation GO:0007060 IEA Subcellular Localization     nucleoplasm GO:0005654 TAS     MutLalpha complex GO:0032389 IBA     male germ cell nucleus GO:0001673 IEA     membrane GO:0016020 IDA     chiasma GO:0005712 IBA     nucleus GO:0005634 IC     synaptonemal complex GO:0000795 IBA