Gene description for MSH3
Gene name mutS homolog 3
Gene symbol MSH3
Other names/aliases DUP
MRP1
Species Homo sapiens
 Database cross references - MSH3
ExoCarta ExoCarta_4437
Vesiclepedia VP_4437
Entrez Gene 4437
HGNC 7326
MIM 600887
UniProt P20585  
 MSH3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MSH3
Molecular Function
    double-stranded DNA binding GO:0003690 IBA
    single-stranded DNA binding GO:0003697 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IPI
    mismatched DNA binding GO:0030983 IDA
    guanine/thymine mispair binding GO:0032137 IDA
    dinucleotide insertion or deletion binding GO:0032139 IDA
    single guanine insertion binding GO:0032142 IDA
    dinucleotide repeat insertion binding GO:0032181 IDA
    oxidized purine DNA binding GO:0032357 IDA
    protein homodimerization activity GO:0042803 IDA
    ATP-dependent DNA damage sensor activity GO:0140664 IEA
Biological Process
    DNA repair GO:0006281 IDA
    mismatch repair GO:0006298 IBA
    mismatch repair GO:0006298 IDA
    mismatch repair GO:0006298 IMP
    mitotic recombination GO:0006312 IBA
    somatic recombination of immunoglobulin gene segments GO:0016447 IBA
    maintenance of DNA repeat elements GO:0043570 IMP
    negative regulation of DNA recombination GO:0045910 IDA
    positive regulation of helicase activity GO:0051096 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 HDA
    MutSbeta complex GO:0032302 IDA
    MutSbeta complex GO:0032302 IPI
 Experiment description of studies that identified MSH3 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MSH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PMS2  
Affinity Capture-MS Homo sapiens
2 NTRK1 4914
Affinity Capture-MS Homo sapiens
3 HIST1H3F 8968
Affinity Capture-MS Homo sapiens
4 PARP1 142
Proximity Label-MS Homo sapiens
5 HUS1  
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
6 CENPA  
Proximity Label-MS Homo sapiens
7 COIL  
Proximity Label-MS Homo sapiens
8 SMARCAD1  
Affinity Capture-MS Homo sapiens
9 Tmed10 68581
Affinity Capture-MS Mus musculus
10 CDC42 998
Affinity Capture-MS Homo sapiens
11 ATG9A 79065
Proximity Label-MS Homo sapiens
12 MSH2 4436
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 ORAOV1  
Co-fractionation Homo sapiens
14 EXO1  
Reconstituted Complex Homo sapiens
15 Dync1li1 235661
Affinity Capture-MS Mus musculus
16 RPA2 6118
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
17 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
18 RPA1 6117
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
19 IKBKG 8517
Affinity Capture-MS Homo sapiens
20 FOXA1  
Affinity Capture-MS Homo sapiens
21 XPA  
Reconstituted Complex Homo sapiens
22 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
23 PIK3CB 5291
Co-fractionation Homo sapiens
24 KARS 3735
Co-fractionation Homo sapiens
25 CTDP1 9150
Affinity Capture-MS Homo sapiens
26 MLH1 4292
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
27 RCHY1  
Two-hybrid Homo sapiens
28 OTUD7B 56957
Co-fractionation Homo sapiens
29 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
31 EMX2  
Affinity Capture-MS Homo sapiens
32 COX8A  
Proximity Label-MS Homo sapiens
33 PIWIL2  
Co-fractionation Homo sapiens
34 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 Batf3  
Affinity Capture-MS Mus musculus
36 PCNA 5111
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 TLR9  
Affinity Capture-MS Homo sapiens
38 MSH6 2956
Co-fractionation Homo sapiens
39 RAD9A  
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
40 LMO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 C9orf78 51759
Affinity Capture-MS Homo sapiens
42 WDR76  
Affinity Capture-MS Homo sapiens
43 MYC  
Affinity Capture-MS Homo sapiens
44 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
45 BARD1 580
Reconstituted Complex Homo sapiens
46 SLX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RAD1  
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
48 ZSCAN26  
Affinity Capture-MS Homo sapiens
49 TSC22D2 9819
Two-hybrid Homo sapiens
50 RPA4  
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
51 CUL7 9820
Affinity Capture-MS Homo sapiens
52 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 KATNB1  
Co-fractionation Homo sapiens
54 MTPN 136319
Affinity Capture-MS Homo sapiens
55 APLF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 BRD3 8019
Affinity Capture-MS Homo sapiens
57 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
58 Cdc26  
Affinity Capture-MS Mus musculus
59 BRCA1 672
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
60 SNX8 29886
Co-fractionation Homo sapiens
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