Gene description for Dync1li1
Gene name dynein cytoplasmic 1 light intermediate chain 1
Gene symbol Dync1li1
Other names/aliases 1110053F02Rik
Dnclic1
LIC-1
Species Mus musculus
 Database cross references - Dync1li1
ExoCarta ExoCarta_235661
Vesiclepedia VP_235661
Entrez Gene 235661
UniProt Q8R1Q8  
 Dync1li1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dync1li1
Molecular Function
    microtubule motor activity GO:0003777 ISS
    ATP binding GO:0005524 IEA
    GDP binding GO:0019003 IEA
    GDP binding GO:0019003 ISO
    protein-macromolecule adaptor activity GO:0030674 IEA
    protein-macromolecule adaptor activity GO:0030674 ISO
    identical protein binding GO:0042802 ISO
    dynein heavy chain binding GO:0045504 IBA
    dynein heavy chain binding GO:0045504 IEA
    dynein heavy chain binding GO:0045504 ISO
    molecular adaptor activity GO:0060090 ISO
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    microtubule-based movement GO:0007018 IBA
    microtubule-based movement GO:0007018 ISO
    microtubule-based movement GO:0007018 ISS
    microtubule-based movement GO:0007018 ISS
    regulation of centrosome cycle GO:0046605 ISO
    cell division GO:0051301 IEA
    regulation of vesicle-mediated transport GO:0060627 ISO
    regulation of vesicle-mediated transport GO:0060627 ISS
    early endosome to recycling endosome transport GO:0061502 IEA
    early endosome to recycling endosome transport GO:0061502 ISO
    positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 ISO
    positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 ISS
    cellular response to nerve growth factor stimulus GO:1990090 ISO
Subcellular Localization
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISS
    spindle pole GO:0000922 ISO
    spindle pole GO:0000922 ISS
    late endosome GO:0005770 ISO
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    cytoplasmic dynein complex GO:0005868 IBA
    cytoplasmic dynein complex GO:0005868 ISO
    cytoplasmic dynein complex GO:0005868 ISS
    microtubule GO:0005874 IEA
    endocytic vesicle membrane GO:0030666 ISO
    endocytic vesicle membrane GO:0030666 ISS
    recycling endosome membrane GO:0055038 IEA
 Experiment description of studies that identified Dync1li1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dync1li1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psmd8 57296
Co-fractionation Mus musculus
2 Clasp1  
Co-fractionation Mus musculus
3 SSR3 6747
Affinity Capture-MS Homo sapiens
4 ROCK1 6093
Affinity Capture-MS Homo sapiens
5 SF1 7536
Affinity Capture-MS Homo sapiens
6 DYNLT1 6993
Affinity Capture-MS Homo sapiens
7 ARHGAP39  
Affinity Capture-MS Homo sapiens
8 SNUPN 10073
Affinity Capture-MS Homo sapiens
9 HIGD1A 25994
Affinity Capture-MS Homo sapiens
10 DYNC1I2 1781
Affinity Capture-MS Homo sapiens
11 GOLIM4 27333
Affinity Capture-MS Homo sapiens
12 Tmem173  
Proximity Label-MS Mus musculus
13 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
14 Foxp3  
Affinity Capture-MS Mus musculus
15 ASB6 140459
Affinity Capture-MS Homo sapiens
16 SLC1A5 6510
Affinity Capture-MS Homo sapiens
17 ASS1 445
Affinity Capture-MS Homo sapiens
18 DCTN2 10540
Affinity Capture-MS Homo sapiens
19 PJA2  
Affinity Capture-MS Homo sapiens
20 PRMT9  
Affinity Capture-MS Homo sapiens
21 IMPACT 55364
Affinity Capture-MS Homo sapiens
22 MSH3 4437
Affinity Capture-MS Homo sapiens
23 COBLL1 22837
Affinity Capture-MS Homo sapiens
24 DCTN3 11258
Affinity Capture-MS Homo sapiens
25 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
26 PITPNA 5306
Affinity Capture-MS Homo sapiens
27 SUGP1  
Affinity Capture-MS Homo sapiens
28 TTC31  
Affinity Capture-MS Homo sapiens
29 DROSHA  
Affinity Capture-MS Homo sapiens
30 Agap2  
Affinity Capture-MS Mus musculus
31 BCL7B  
Affinity Capture-MS Homo sapiens
32 DYNC1LI2 1783
Affinity Capture-MS Homo sapiens
33 KCNAB2 8514
Affinity Capture-MS Homo sapiens
34 DYNLRB1 83658
Affinity Capture-MS Homo sapiens
35 BPTF 2186
Affinity Capture-MS Homo sapiens
36 BLMH 642
Affinity Capture-MS Homo sapiens
37 EMR2  
Affinity Capture-MS Homo sapiens
38 DCTN1 1639
Affinity Capture-MS Homo sapiens
39 FNDC3A 22862
Affinity Capture-MS Homo sapiens
40 TTC9C 283237
Affinity Capture-MS Homo sapiens
41 ACTR1A 10121
Affinity Capture-MS Homo sapiens
42 MED25  
Affinity Capture-MS Homo sapiens
43 INPP5B 3633
Affinity Capture-MS Homo sapiens
44 DNM2 1785
Affinity Capture-MS Homo sapiens
45 LYST 1130
Affinity Capture-MS Homo sapiens
46 MGA  
Affinity Capture-MS Homo sapiens
47 FAM114A2  
Affinity Capture-MS Homo sapiens
48 SCAMP3 10067
Affinity Capture-MS Homo sapiens
49 TBC1D9B 23061
Affinity Capture-MS Homo sapiens
50 DYNLL1 8655
Affinity Capture-MS Homo sapiens
51 U2SURP 23350
Affinity Capture-MS Homo sapiens
52 PSMD6 9861
Affinity Capture-MS Homo sapiens
53 SIPA1L3  
Affinity Capture-MS Homo sapiens
54 DNAJC8 22826
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Dync1li1 is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Aggrephagy IEA Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Asparagine N-linked glycosylation IEA Reactome
Autophagy IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
COPI-independent Golgi-to-ER retrograde traffic IEA Reactome
COPI-mediated anterograde transport IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
ER to Golgi Anterograde Transport IEA Reactome
Golgi-to-ER retrograde transport IEA Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic IEA Reactome
M Phase IEA Reactome
Macroautophagy IEA Reactome
Membrane Trafficking IEA Reactome
Metabolism of proteins IEA Reactome
MHC class II antigen presentation IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
Neutrophil degranulation IEA Reactome
Post-translational protein modification IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
Selective autophagy IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Transport to the Golgi and subsequent modification IEA Reactome
Vesicle-mediated transport IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here