Gene description for SNUPN
Gene name snurportin 1
Gene symbol SNUPN
Other names/aliases KPNBL
RNUT1
Snurportin1
Species Homo sapiens
 Database cross references - SNUPN
ExoCarta ExoCarta_10073
Vesiclepedia VP_10073
Entrez Gene 10073
HGNC 14245
MIM 607902
UniProt O95149  
 SNUPN identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SNUPN
Molecular Function
    RNA cap binding GO:0000339 TAS
    protein transporter activity GO:0008565 IEA
Biological Process
    protein import into nucleus GO:0006606 IEA
    ncRNA metabolic process GO:0034660 TAS
    gene expression GO:0010467 TAS
    spliceosomal snRNP assembly GO:0000387 TAS
    snRNA import into nucleus GO:0061015 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
    nuclear pore GO:0005643 TAS
 Experiment description of studies that identified SNUPN in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SNUPN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 XPO1 7514
Invivo Homo sapiens
Invitro Homo sapiens
2 ENO2 2026
Two-hybrid Homo sapiens
3 PEX5 5830
Two-hybrid Homo sapiens
4 KPNB1 3837
Invivo Homo sapiens
Invitro Homo sapiens
5 TNNT3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SNUPN is involved
PathwayEvidenceSource
snRNP Assembly TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here